Research Progress in Analytical Methods for Structures of Phytogenic Polysaccharides

JING Yongshuai; MA Yunfeng; LI Mingsong; YANG Jinxin; ZHANG Ruijuan; ZHANG Danshen; ZHENG Yuguang; WU Lanfang

doi:10.13386/j.issn1002-0306.2021010181

Volume 43 Issue 3

Jan. 2022

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Science and Technology of Food Industry > 2022 > 43(3): 411-421. > DOI: 10.13386/j.issn1002-0306.2021010181

JING Yongshuai, MA Yunfeng, LI Mingsong, et al. Research Progress in Analytical Methods for Structures of Phytogenic Polysaccharides[J]. Science and Technology of Food Industry, 2022, 43(3): 411−421. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021010181.

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Research Progress in Analytical Methods for Structures of Phytogenic Polysaccharides

1.
College of Chemistry and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China
2.
College of Pharmacology, Hebei University of Chinese Medicine, Shijiazhuang 050200, China

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Received Date: January 24, 2021
Available Online: November 28, 2021

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Abstract

Abstract

Phytogenic polysaccharide, a kind of natural macromolecule, is wide spread occurrence in phytogenic cells and has many kinds of biological activities, such as anti-tumor, anti-oxidation, immunomodulation, and etc. The structure of polysaccharide is a key factor affecting its biological activity. Due to the large molecular weight and complex structure of polysaccharide, the in-depth study of polysaccharide is limited. Therefore, this paper introduces the research methods of the primary structure, such as gas chromatography, liquid chromatography, infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectrometry, as well as advanced structural analysis methods such as atomic force microscopy, X ray diffraction and circular dichrois, and summarizes the construction of multidimensional fingerprint and molecular model of phytogenic polysaccharides, which provides a new idea for the study of polysaccharide structure and lays a foundation for the development and utilization of polysaccharides.
- phytogenic polysaccharides,
- structural,
- analytical method

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[1]	边亮, 陈华国, 周欣. 植物多糖的抗肿瘤活性研究进展[J]. 食品科学,2020,41(7):275−282. [BIAN L, CHEN H G, ZHOU X. Recent advances in understanding the antitumor activity of polysaccharides from plants[J]. Food Science,2020,41(7):275−282. doi: 10.7506/spkx1002-6630-20190330-392
[2]	吴梦琪, 夏玮, 徐志珍, 等. 植物多糖的分离纯化、结构解析及生物活性研究进展[J]. 化学世界,2019,60(11):737−747. [WU M Q, XIA W, XU Z Z, et al. Review on isolation and purification, structural elucidation and biological activity of botanical polysaccharides[J]. Chemical World,2019,60(11):737−747.
[3]	唐圆, 谢果珍. 多糖与肠道菌群的相互作用研究进展[J]. 现代农业科技,2020(9):225−227. [TANG Y, XIE G Z. Research progress on interaction between polysaccharide and gut microbiota[J]. Modern Agricultural Science and Technology,2020(9):225−227. doi: 10.3969/j.issn.1007-5739.2020.09.135
[4]	张蕊馨, 张彦华, 周迎春, 等. 中药多糖化学结构及药理作用研究进展[J]. 黑龙江中医药,2018,47(1):88−89. [ZHANG R X, ZHANG Y H, ZHOU Y C, et al. Research progress on the chemical structure and pharmacological effects of polysaccharides from traditional Chinese medicine[J]. Heilongjiang Journal of Traditional Chinese Medicine,2018,47(1):88−89.
[5]	张永文. 中药多糖成分的质控及评价要点[J]. 中国新药杂志,2015,24(3):260−263, 280. [ZHANG Y W. Quality control and evaluation of polysaccharide compositions in Chinese herbal medicines[J]. Chinese Journal of New Drugs,2015,24(3):260−263, 280.
[6]	高怡婷, 柳文媛. 多糖的制备工艺与质量控制研究进展[J]. 药学进展,2016,40(3):205−211. [GAO Y T, LIU W Y. Advances in research on preparation technique and quality control of polysaccharides[J]. Progress in Pharmaceutical Sciences,2016,40(3):205−211.
[7]	HAN Q B. Critical problems stalling progress in natural bioactive polysaccharide research and development[J]. Journal of Agricultural and Food Chemistry,2018,66(18):4581−4583. doi: 10.1021/acs.jafc.8b00493
[8]	谭西, 周欣, 陈华国. 植物多糖构效关系研究进展[J]. 中国中药杂志,2017,42(21):4104−4109. [TAN X, ZHOU X, CHEN H G. Structure-activity relationship of plant polysaccharides[J]. China Journal of Chinese Materia Medica,2017,42(21):4104−4109.
[9]	肖作奇. 中药多糖质量控制研究进展[J]. 中国医药导报,2015,12(4):159−164. [XIAO Z Q. Studies advances on quality control of polysaccharide from traditional Chinese medicine[J]. China Medical Herald,2015,12(4):159−164.
[10]	张学英, 黄忠意, 章发盛, 等. 两种检测还原糖方法的比较[J]. 食品与机械,2017,33(2):66−69. [ZHANG X Y, HUANG Z Y, ZHANG F S, et al. Comparative study on two methods for sugar detection in Jerusalem Artichoke[J]. Food & Machinery,2017,33(2):66−69.
[11]	段永忠, 唐湘华, 慕跃林, 等. 双波长法测定二元混合体系中戊糖的含量[J]. 生物技术,2009,19(1):44−46. [DUAN Y Z, TANG X H, MU Y L, et al. Quantitative determination of pentose in duplex mixture system using double-wavelength method[J]. Biotechnology,2009,19(1):44−46.
[12]	张妍, 刘太林. 苯酚-硫酸法与蒽酮-硫酸法测定麦冬中麦冬多糖含量的比较研究[J]. 现代食品,2018(18):95−102. [ZHANG Y, LIU T L. Comparison of phenol-sulfuric and anthrone-sulfuric acid methods for determination of polysaccharide in Radix Ophiopogonis[J]. Modern Food,2018(18):95−102.
[13]	张小贝, 朱国鹏, 祝志欣, 等. 利用3, 5-二硝基水杨酸法测定菜用甘薯叶中的多糖含量[J]. 热带生物学报,2017,8(3):359−363,377. [ZHANG X B, ZHU G P, ZHU Z X, et al. Determination of the polysaccharide content of sweet potato leaves by using 3'5'-dinitrosalicylic acid (DNS)[J]. Journal of Tropical Biology,2017,8(3):359−363,377.
[14]	陈立江, 王菁, 刘宇, 等. 南瓜多糖含量测定方法比较[J]. 辽宁大学学报(自然科学版),2014,41(1):76−81. [CHEN L J, WANG J, LIU Y, et al. The content of pumpkin polysaccharide determination comparison[J]. Journal of Liaoning University(Natural Science Edition),2014,41(1):76−81.
[15]	国家药典委员会. 中华人民共和国药典: 一部[S]. 2020年版. 北京: 中国医药科技出版社, 2020: 86−320. Chinese Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China (in Chinese): Vol. 1[S]. 2020 Edition. Beijing: China Medical Science Press, 2020: 76−81.
[16]	司雄元, 牛子牛, 储思琴, 等. 气相色谱法测定多糖样品中单糖的含量[J]. 理化检验(化学分册),2018,54(10):1198−1201. [SI X Y, NIU Z N, CHU S Q, et al. GC determination of monosaccharides in polysaccharides samples[J]. Physical Testing and Chemical Analysis (Part B: Chemical Analysis),2018,54(10):1198−1201.
[17]	丁洁, 闫光玲, 杨培, 等. 金银花多糖的指纹图谱及体外抗病毒活性研究[J]. 中国药房,2020,31(9):1061−1067. [DING J, YAN G L, YANG P, et al. Study on fingerprint and in vitro antiviral activity of Lonicera japonica polysaccharide[J]. China Pharmacy,2020,31(9):1061−1067. doi: 10.6039/j.issn.1001-0408.2020.09.08
[18]	王小燕, 郭常润, 常军民, 等. 怀牛膝多糖的柱前衍生化-HPLC指纹图谱建立及单糖成分含量测定[J]. 中国药房,2021,32(3):294−300. [WANG X Y, GUO C R, CHANG J M, et al. Establishment of pre-column derivatization-HPLC fingerprint and content determination of monosaccharide composition from Achyranthes bidentata polysaccharides[J]. China Pharmacy,2021,32(3):294−300. doi: 10.6039/j.issn.1001-0408.2021.03.08
[19]	席璟睿, 张懿琳, 吴梦琪, 等. 基于化学计量学的枸杞多糖部分酸水解产物PMP-HPLC指纹图谱[J/OL]. 食品工业科技, 2021: 1−12 (2021-03-18). XI J R, ZHANG Y L, WU M Q, et al. PMP-HPLC fingerprint of partial acid hydrolysate of Lycium barbarum polysaccharides based on the chemometric methods[J/OL]. Science and Technology of Food Industry, 2021: 1−12 (2021-03-18).
[20]	赖戈娜, 贾文玉, 罗思婉, 等. 猪苓多糖的PMP柱前衍生化-HPLC指纹图谱研究[J]. 中国药房,2020,31(7):788−793. [LAI G N, JIA W Y, LUO S W, et al. Study on PMP pre-column derivatization-HPLC fingerprint of Polyporus polysaccharide[J]. China Pharmacy,2020,31(7):788−793. doi: 10.6039/j.issn.1001-0408.2020.07.05
[21]	LONG H L, ZHANG J X, GUO J L, et al. Development of specific and quantitative methods for the quality control of the polysaccharides from sea-tangle and sargassum[J]. Chinese Journal of Natural Medicines,2016,14(12):954−960. doi: 10.1016/S1875-5364(17)30022-5
[22]	田光辉, 刘存芳, 危冲, 等. 中药糙苏中的多糖研究[J]. 食品科技,2009,34(6):206−209. [TIAN G H, LIU C F, WEI C, et al. Study on the polysaccharide obtained from medicinal herb Phlomis umbrosa[J]. Food Science and Technology,2009,34(6):206−209.
[23]	王少杰, 巴娟, 张勇军, 等. 玉屏风复合多糖的质量控制研究[J]. 动物医学进展,2019,40(11):68−72. [WANG S J, BA J, ZHANG Y J, et al. Study on quality control of Yupingfeng polysaccharides[J]. Progress in Veterinary Medicine,2019,40(11):68−72.
[24]	邓勇, 张杰良, 王兰英, 等. 薄层色谱法分析不同虫草多糖的单糖组成[J]. 药物分析杂志,2018,38(1):13−21. [DENG Y, ZHANG J L, WANG L Y, et al. Analysis of monosaccharide composition in polysaccharides of Cordyceps spp. by TLC[J]. Chinese Journal of Pharmaceutical Analysis,2018,38(1):13−21.
[25]	DI X, CHAN K K C, LEUNG H W, et al. Fingerprint profiling of acid hydrolyzates of polysaccharides extracted from the fruiting bodies and spores of Lingzhi by high-performance thin-layer chromatography[J]. Journal of Chromatography A,2003,1018(1):85−95. doi: 10.1016/j.chroma.2003.07.015
[26]	陈蕾, 何新苗, 孟磊, 等. 洋甘菊多糖中单糖组分的高效液相色谱及高效毛细管电泳测定比较[J]. 食品与药品,2019,21(5):347−351. [CHEN L, HE X M, MENG L, et al. Comparison of monosaccharide composition analysis of polysaccharide from Matricaria Chamomilla L. by HPLC and HPCE[J]. Food and Drug,2019,21(5):347−351. doi: 10.3969/j.issn.1672-979X.2019.05.003
[27]	陈传平, 吴剑峰, 方士英, 等. 柱前衍生-高效毛细管电泳法分析金樱子多糖中单糖组成[J]. 黄山学院学报,2018,20(3):60−64. [CHEN C P, WU J F, FANG S Y, et al. An analysis on the monosaccharide composition of polysaccharide in Rosa laevigata by pre-column derivatization and high performance capillary electrophoresis[J]. Journal of Huangshan University,2018,20(3):60−64. doi: 10.3969/j.issn.1672-447X.2018.03.016
[28]	赵颖, 宋新波, 张丽娟, 等. 高效凝胶色谱法测定甘草多糖分子量及其分子量分布[J]. 天津中医药,2015,32(1):46−48. [ZHAO Y, SONG X B, ZHANG L J, et al. Determination of molecular weight and weight distribution in Licorice polysaccharide by HPGPC[J]. Tianjin Journal of Traditional Chinese Medicine,2015,32(1):46−48.
[29]	ZHAO S J, HAN Z M, YANG L M, et al. Extraction, characterization and antioxidant activity evaluation of polysaccharides from Smilacina japonica[J]. International Journal of Biological Macromolecules,2020,151:576−583. doi: 10.1016/j.ijbiomac.2020.02.015
[30]	王巧娥, 谢丹, 钱洁, 等. 库拉索芦荟凝胶多糖的GPC指纹图谱研究[J]. 中药材,2015,38(10):2070−2075. [WANG Q E, XIE D, QIAN J, et al. GPC fingerprint chromatograms of Aloe vera leaf gel polysaccharides[J]. Journal of Chinese Medicinal Materials,2015,38(10):2070−2075.
[31]	邓樑钧, 张维, 邱飞. 短葶山麦冬多糖质量控制方法研究[J]. 海峡药学,2017,29(6):32−35. [DENG L J, ZHANG W, QIU F. Studies on the method of quality control of Liriope Muscari (Decne) Baily polysaccharides[J]. Strait Pharmaceutical Journal,2017,29(6):32−35. doi: 10.3969/j.issn.1006-3765.2017.06.014
[32]	侯重文, 朱梓昂, 张金华, 等. 高效凝胶色谱法测定贻贝多糖含量及分子量[J]. 中国生化药物杂志,2016,36(11):9−12. [HOU Z W, ZHU Z A, ZHANG J H, et al. Determination of the content and the molecular weight of Mussel polysaccharide by GPC[J]. Chinese Journal of Biochemical and Pharmaceuticals,2016,36(11):9−12.
[33]	闫光玲, 张锋, 金娟, 等. 金银花多糖分子量及单糖组成研究[J]. 中国中医药信息杂志,2019,26(2):97−101. [YAN G L, ZHANG F, JIN J, et al. Study on molecular weight and monosaccharide composition of polysaccharide from Lonicerae Japonicae Flos[J]. Chinese Journal of Information on Traditional Chinese Medicine,2019,26(2):97−101. doi: 10.3969/j.issn.1005-5304.2019.02.021
[34]	XU J, LI S L, YUE R Q, et al. A novel and rapid HPGPC-based strategy for quality control of saccharide-dominant herbal materials: Dendrobium officinale, a case study[J]. Analytical & Bioanalytical Chemistry,2014,406(25):6409−6417.
[35]	赵珊, 许加超, 付晓婷, 等. 褐藻寡糖分子量测定方法的研究[J]. 食品工业科技,2011,32(12):486−488. [ZHAO S, XU J C, FU X T, et al. Study on the determination method of molecular weight of alginate oligosaccharide[J]. Science and Technology of Food Industry,2011,32(12):486−488.
[36]	秦建鲜, 黄锁义. 中药多糖相对分子质量测定方法的概述[J]. 中国实验方剂学杂志,2015,21(14):226−229. [QIN J X, HUANG S Y. Determination methods of molecular weight of polysaccharides in traditional Chinese medicine[J]. Chinese Journal of Experimental Traditional Medical Formulae,2015,21(14):226−229.
[37]	XU S Q, XU X J, ZHANG L N, et al. Effect of heating on chain conformation of branched β-Glucan in water[J]. Journal of Physical Chemistry B,2013,117(28):8370−8377. doi: 10.1021/jp403202u
[38]	胡卫珍, 齐振宇, 陈晓芳, 等. 凝胶渗透色谱联用多角度激光光散射测定铁皮石斛多糖分子量及其分布[J]. 浙江农业科学,2020,61(6):1166−1167,1175. [HU W Z, QI Z Y, CHEN X F, et al. Determination of molecular weight and distribution of polysaccharides in Dendrobium officinale by size exclusion chromatography-multi angle laser light scattering[J]. Journal of Zhejiang Agricultural Sciences,2020,61(6):1166−1167,1175.
[39]	王川, 张燕, 李楠, 等. HPSEC-ELSD法同时测定白及多糖的分子量和含量[J]. 中国药房,2018,29(9):1198−1201. [WANG C, ZHANG Y, LI N, et al. Determination of molecular weight and content of Bletilla striata polysaccharide by HPSEC-ELSD[J]. China Pharmacy,2018,29(9):1198−1201. doi: 10.6039/j.issn.1001-0408.2018.09.11
[40]	张鑫, 刘洋, 程亚茹, 等. 枸杞多糖分子量分布测定与抗炎活性关联研究[J]. 北京中医药大学学报,2020,43(11):959−964. [ZHANG X, LIU Y, CHENG Y R, et al. Molecular weight distribution of Lycium barbarum polysaccharides and its relation with anti-inflammatory activity[J]. Journal of Beijing University of Traditional Chinese Medicine,2020,43(11):959−964. doi: 10.3969/j.issn.1006-2157.2020.11.011
[41]	JIA Y A, XUE Z H, WANG Y J, et al. Chemical structure and inhibition on α-glucosidase of polysaccharides from corn silk by fractional precipitation[J]. Carbohydrate Polymers,2021,252(3):117185.
[42]	ABUDUWAILI A, MUTAILIFU P, NUERXIATI R, et al. Structure and biological activity of polysaccharides from Nitraria sibirica pall fruit[J]. Food Bioscience,2021,40(83):100903.
[43]	SHI X D, LI O Y, YIN J Y, et al. Structure identification of α-glucans from Dictyophora echinovolvata by methylation and 1D/2D NMR spectroscopy[J]. Food Chemistry,2019,271:338−344. doi: 10.1016/j.foodchem.2018.07.160
[44]	DENG Y, CHEN L X, HAN B X, et al. Qualitative and quantitative analysis of specific polysaccharides in Dendrobium huoshanense by using saccharide mapping and chromatographic methods[J]. Journal of Pharmaceutical and Biomedical Analysis,2016,129:163−171. doi: 10.1016/j.jpba.2016.06.051
[45]	WU M Q, LI W, ZHANG Y L, et al. Structure characteristics, hypoglycemic and immunomodulatory activities of pectic polysaccharides from Rosa setate x Rosa rugosa waste[J]. Carbohydrate polymers,2021,253:117190. doi: 10.1016/j.carbpol.2020.117190
[46]	XIA Y G, LIANG J, YANG B Y, et al. Structural studies of an arabinan from the stems of Ephedra sinica by methylation analysis and 1D and 2D NMR spectroscopy[J]. Carbohydrate Polymers,2015,121:449−456.
[47]	ZHOU R M, CUI M X, WANG Y, et al. Isolation, structure identification and anti-inflammatory activity of a polysaccharide from Phragmites rhizoma[J]. International Journal of Biological Macromolecules,2020,161:810−817. doi: 10.1016/j.ijbiomac.2020.06.124
[48]	YUE H, XU Q Q, BIAN G Y, et al. Structure characterization and immunomodulatory activity of a new neutral polysaccharide SMP-0b from Solanum muricatum[J]. International Journal of Biological Macromolecules,2020,155:853−860. doi: 10.1016/j.ijbiomac.2019.11.071
[49]	YIN L, FU S S, WU R J, et al. A neutral polysaccharide from green tea: Structure, effect on α-amylase activity and hydrolysis property[J]. Archives of Biochemistry and Biophysics,2020,687:108369. doi: 10.1016/j.abb.2020.108369
[50]	顾菲菲, 李佳, 杨晨东, 等. 碱提灵芝多糖的分离纯化、结构表征及免疫活性评价[J]. 中草药,2018,49(10):2359−2364. [GU F F, LI J, YANG C D, et al. Fractionation, structural characterization, and immunomodulatory activity of polysaccharide isolated from Ganoderma lucidum[J]. Chinese Traditional and Herbal Drugs,2018,49(10):2359−2364.
[51]	GUO C L, ZHANG S H, WANG Y Q, et al. Isolation and structure characterization of a polysaccharide from Crataegus pinnatifida and its bioactivity on gut microbiota[J]. International Journal of Biological Macromolecules,2020,154:82−91. doi: 10.1016/j.ijbiomac.2020.03.058
[52]	刘文娟, 郝晓伟, 靖会, 等. 植物多糖的高级结构解析技术进展[J]. 西北药学杂志,2017,32(6):810−813. [LIU W J, HAO X W, JING H, et al. Review of the analytical techniques for advanced structures of botanical polysaccharides[J]. Northwest Pharmaceutical Journal,2017,32(6):810−813. doi: 10.3969/j.issn.1004-2407.2017.06.037
[53]	郑恒光, 沈恒胜, 杨道富, 等. 杏鲍菇菇头多糖的结构鉴定及生物活性评价[J]. 食品科学,2019,40(22):7−13. [ZHENG H G, SHEN H S, YANG D F, et al. Structural characterization and antitumor activity of crude polysaccharide extracted from the stalk residue of Pleurotus eryngii[J]. Food Science,2019,40(22):7−13. doi: 10.7506/spkx1002-6630-20181126-292
[54]	CHOUANA T, PIERRE G, VIAL C, et al. Structural characterization and rheological properties of a galactomannan from Astragalus gombo Bunge seeds harvested in Algerian Sahara[J]. Carbohydrate Polymers,2017,175:387−394. doi: 10.1016/j.carbpol.2017.08.003
[55]	HUANG S Q, LI J W, LI Y Q, et al. Purification and structural characterization of a new water-soluble neutral polysaccharide GLP-F1-1 from Ganoderma lucidum[J]. International Journal of Biological Macromolecules,2011,48(1):165−169. doi: 10.1016/j.ijbiomac.2010.10.015
[56]	刘丽丽. 酸性多糖甲基化分析方法的改进[D]. 青岛: 中国海洋大学, 2014. LIU L L. Improvement of methods for methylation analysis of acidic polysaccharides[D]. Qingdao: Ocean University China, 2014.
[57]	徐航, 朱锐, 刘玮, 等. 多糖高级结构解析方法的研究进展[J]. 药学进展,2015,39(5):364−369. [XU H, ZHU R, LIU W, et al. Research progress in analytical methods for advanced structures of polysaccharides[J]. Progress in Pharmaceutical Sciences,2015,39(5):364−369.
[58]	JI X L, ZHANG F, ZHANG R, et al. An acidic polysaccharide from Ziziphus Jujuba cv. Muzao: Purification and structural characterization[J]. Food Chemistry,2019,274:494−499. doi: 10.1016/j.foodchem.2018.09.037
[59]	KAVITAKE D, DEVI P B, SINGH S P, et al. Characterization of a novel galactan produced by Weissella confuse KR780676 from an acidic fermented food[J]. International Journal of Biological Macromolecules,2016,86:681−689. doi: 10.1016/j.ijbiomac.2016.01.099
[60]	刘贺, 张红运, 杨立娜, 等. 多糖化学结构解析研究进展[J]. 渤海大学学报(自然科学版),2018,39(2):97−106. [LIU H, ZHANG H Y, YANG L N, et al. A review about the research of polysaccharide chemical structure analysis[J]. Journal of Bohai University(Natural Science Edition),2018,39(2):97−106.
[61]	PARHAT R, AYTURSUN A, MA S J, et al. Isolations, characterizations and bioactivities of polysaccharides from the seeds of three species Glycyrrhiza[J]. International Journal of Biological Macromolecules,2020,145:364−371. doi: 10.1016/j.ijbiomac.2019.12.107
[62]	REN Y P, LIU S X. Effects of separation and purification on structural characteristics of polysaccharide from quinoa (Chenopodium quinoa willd)[J]. Biochemical and biophysical research communications,2020,522(2):286−291. doi: 10.1016/j.bbrc.2019.10.030
[63]	ZHANG W J, HUANG J, WANG W, et al. Extraction, purification, characterization and antioxidant activities of polysaccharides from Cistanche tubulosa[J]. International Journal of Biological Macromolecules,2016,93:448−458. doi: 10.1016/j.ijbiomac.2016.08.079
[64]	XIA Y G, HUANG Y X, LIANG J, et al. Comparable studies of two polysaccharides from leaves of Acanthopanax senticosus: Structure and antioxidation[J]. International Journal of Biological Macromolecules,2020,147:350−362. doi: 10.1016/j.ijbiomac.2019.12.244
[65]	ENGELSEN S B, HANSEN P I, PEREZ S. POLYS 2.0: An open source software package for building three-dimensional structures of polysaccharides[J]. Biopolymers,2014,101(7):733−743. doi: 10.1002/bip.22449
[66]	KUTTEL M M, STAHLE J, WIDMALM G. Carb Builder: Software for building molecular models of complex oligo- and polysaccharide structures[J]. Journal of Computational Chemistry,2016,37(22):1−8.
[67]	郑振佳, 朱文卿, 梁浩, 等. 指纹图谱在食品分析中的应用研究进展[J/OL]. 食品工业科技, 2021: 1−20 (2021-03-18). ZHENG Z J, ZHU W Q, LIANG H, et al. Advances in application of fingerprint technology in food analysis[J/OL]. Science and Technology of Food Industry, 2021: 1−20 (2021-03-18).
[68]	ARYANI S, MOHAMAD R, LATIFAH KDA. Discrimination of red and white rice bran from Indonesia using HPLC fingerprint analysis combined with chemometrics[J]. Food Chemistry,2017,221:1717−1722. doi: 10.1016/j.foodchem.2016.10.114
[69]	YANG W L, HU M H, CHEN S W, et al. Identification of adulterated cocoa powder using chromatographic fingerprints of polysaccharides coupled with principal component analysis[J]. Food Analytical Methods,2015,8(9):2360−2367. doi: 10.1007/s12161-015-0126-6
[70]	曾贞, 孙恒, 陈骏飞, 等. FTIR结合化学计量学快速预测铁皮石斛中总多糖含量[J]. 江西农业学报,2018,30(1):117−121. [ZENG Z, SUN H, CHEN J F, et al. Rapid forecast of total polysaccharide content in Dendrobium officinale by FTIR combined with chemometrics[J]. Acta Agriculturae Jiangxi,2018,30(1):117−121.
[71]	曹玲, 董辉, 孙晖, 等. 多维指纹图谱在中药分析中的应用[C]. 中华中医药学会. 中华中医药学会第七次中药分析学术交流会会议论文集. 中华中医药学会: 中华中医药学会, 2014: 509−511. CAO L, DOGN H, SUN H, et al. The application of multi-dimensional fingerprints on TCM quality evaluation[C]. The Chinese Society of Traditional Chinese Medicine. Proce edings of the Seventh TCM Analysis Academic Exchange Conference of the Chinese Society of Traditional Chinese Medicine. Chinese Society of Traditional Chinese Medicine: Chinese Society of TCM, 2014: 509−511.
[72]	WANG Y F, XIAN J H, XI X G, et al. Multi-fingerprint and quality control analysis of tea polysaccharides[J]. Carbohydrate Polymers,2013,92(1):583−590. doi: 10.1016/j.carbpol.2012.09.004
[73]	CHENG J, HE S Y, WAN Q, et al. Multiple fingerprinting analyses in quality control of Cassiae Semen polysaccharides[J]. Journal of Chromatography B,2018,1077-1078:22−27. doi: 10.1016/j.jchromb.2018.01.032
[74]	LI H, GONG X Q, WANG Z C, et al. Multiple fingerprint profiles and chemometrics analysis of polysaccharides from Sarcandra glabra[J]. International Journal of Biological Macromolecules,2019,123:957−967. doi: 10.1016/j.ijbiomac.2018.11.103
[75]	DENG Y, HAN B X, HU D J, et al. Qualitation and quantification of water soluble non-starch polysaccharides from Pseudostellaria heterophylla in China using saccharide mapping and multiple chromatographic methods[J]. Carbohydrate Polymers,2018,199:619−627. doi: 10.1016/j.carbpol.2018.06.063
[76]	XIA Y G, YU S M, LIANG J, et al. Chemical fingerprinting techniques for the differentiation of polysaccharides from genus Astragalus[J]. Journal of Pharmaceutical and Biomedical Analysis,2020,178:112898. doi: 10.1016/j.jpba.2019.112898
[77]	LI C Y, CHEN H Y, LIU W P, et al. Multi-fingerprint profiling combined with chemometric methods for investigating the quality of Astragalus polysaccharides[J]. International Journal of Biological Macromolecules,2019,123:766−774. doi: 10.1016/j.ijbiomac.2018.11.037
[78]	LIU W, XU J N, ZHU R, et al. Fingerprinting profile of polysaccharides from Lycium barbarum using multiplex approaches and chemometrics[J]. International Journal of Biological Macromolecules,2015,78:230−237. doi: 10.1016/j.ijbiomac.2015.03.062
[79]	DONG Y T, PEI F, SU A X, et al. Multiple fingerprint and fingerprint-activity relationship for quality assessment of polysaccharides from Flammulina velutipes[J]. Food and Chemical Toxicology,2020,135:110944. doi: 10.1016/j.fct.2019.110944
[80]	XIA Y G, LI X, YU L S, et al. Structural-fingerprinting of polysaccharides to discern Panax species by means of gas-liquid chromatography and mass spectrometry[J]. International Journal of Biological Macromolecules,2020,151:932−943. doi: 10.1016/j.ijbiomac.2020.02.194
[81]	WANG H X, YI Y, SUN J, et al. Fingerprint profiling of polysaccharides from different parts of lotus root varieties[J]. Rsc Advances,2018,8(30):16574−16584. doi: 10.1039/C8RA01104D

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