Effect of Polyphenols from <i>Enteromorpha prolifera</i> on Reducing Blood Glucose in Type 2 Diabetic Mice

QIU Xiaoming; GUO Xin; HUANG Congliang

doi:10.13386/j.issn1002-0306.2023030168

Volume 45 Issue 1

Dec. 2023

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Science and Technology of Food Industry > 2024 > 45(1): 318-324. > DOI: 10.13386/j.issn1002-0306.2023030168

QIU Xiaoming, GUO Xin, HUANG Congliang. Effect of Polyphenols from Enteromorpha prolifera on Reducing Blood Glucose in Type 2 Diabetic Mice[J]. Science and Technology of Food Industry, 2024, 45(1): 318−324. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023030168.

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Effect of Polyphenols from Enteromorpha prolifera on Reducing Blood Glucose in Type 2 Diabetic Mice

QIU Xiaoming^{1, 2,},
GUO Xin^{1, 2},
HUANG Congliang^1, ,

1.
Food Engineering School, Zhangzhou Institute of Technology, Zhangzhou 363000, China
2.
Applied Technical Engineering Center of Further Processing and Safety of Agricultural Products, Higher Education Institutions in Fujian Province, Zhangzhou 363000, China

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Received Date: March 16, 2023
Available Online: November 05, 2023

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Abstract

Abstract

Objective: The aim of this work was to explore the hypoglycemic effect of Enteromorpha prolifera polyphenols (EPP) on type 2 diabetic mice, and to provide theoretical basis for the development of EPP products. Methods: EPP crude was extracted from Enteromorpha prolifera by ethanol solution extraction, and purified by silica gel column chromatography. The model of type 2 diabetes in mice was established by alloxan. The experimental mice were divided into blank control group, model control group, EPP low dose group (EPP-L), EPP midium dose group (EPP-M), EPP high dose group (EPP-H), and positive control group. The basic indicators of mice, as well as lipid metabolism and serum antioxidant indicators, were measured by continuous gastric perfusion for 4 weeks. Results: At the 4th week of the experiment, the averaged weight of mice in EPP-H group reached 32.16±1.97 g, which was not significantly different from that of the positive control group (P>0.05). The fasting blood glucose concentration of EPP-H group was 11.78±1.62 mmol/L, and there was no significant difference between EPP-H group and the positive control group (P>0.05). EPP-H clearly had significantly improved both the glucose tolerance (P<0.05) and the abnormal glucose tolerance of mice. The concentrations of superoxide dismutase, catalase, glutathione peroxidase, high-density lipoprotein cholesterol, and serum insulin levels in EPP-H mice were 157.36±6.71 U/mg, 168.07±1.77 U/mg, 378.14±9.74 U/mg, 1.31±0.04 mmol/L, and 19.03±2.01 mU/L, respectively, compared with the model control group, it was significantly increased (P<0.01), and the contents of malondialdehyde, triglyceride, total cholesterol and low-density lipoprotein cholesterol were significantly decreased (P<0.05). Conclusion: Polyphenols from Enteromorpha prolifera can effectively improve the basal metabolism of type 2 diabetic mice and repair the peroxide damage of diabetic mice, and may play a role in lowering blood sugar.
- Enteromorpha prolifera,
- polyphenols,
- hypoglycemic,
- efficacy

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