Research Progress on Application of Nisin in Food Storage and Preservation Based on Patent Analysis

WU Juan; WU Jie; LIN Lin; CUI Haiying

doi:10.13386/j.issn1002-0306.2022070385

Volume 44 Issue 3

Jan. 2023

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Science and Technology of Food Industry > 2023 > 44(3): 11-18. > DOI: 10.13386/j.issn1002-0306.2022070385

WU Juan, WU Jie, LIN Lin, et al. Research Progress on Application of Nisin in Food Storage and Preservation Based on Patent Analysis[J]. Science and Technology of Food Industry, 2023, 44(3): 11−18. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022070385.

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Research Progress on Application of Nisin in Food Storage and Preservation Based on Patent Analysis

WU Juan^1,,
WU Jie^{1, 2, ,},
LIN Lin³,
CUI Haiying³

1.
Intellectual Property Center, Jiangsu University of Science and Technology, Zhenjiang 212003, China
2.
Periodicals Agency, Jiangsu University of Science and Technology, Zhenjiang 212100, China
3.
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China

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Received Date: August 02, 2022
Available Online: November 28, 2022

Graphical Abstract

Abstract

Abstract

As a kind of food additive with natural, high efficiency and safety, nisin was widely used in food storage and preservation due to its broad spectrum antibacterial activity against Gram-positive bacteria. This article reviews the patents of Nisin in the application of food storage and preservation based on the existing patent data and progress in techniques. It focuses on the current situation in patent application of Nisin from the aspects of single application, compound antiseptic, Nisin combined with physical technology, microencapsulation and antibacterial foodstuff packaging film. The results imply that enterprises should accelerate patent application in the hot research field, such as the synergistic antimicrobial activity of Nisin and other food additives, and rationally utilize invalid patent technology. Besides, they should avoid the risk of patent infringement and realize the high speed development of the Nisin application technology.
- Nisin,
- food,
- storage and preservation,
- patent analysis,
- application

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References (58)

References

[1]	王佳宇, 胡文忠, 管玉格, 等. 乳酸链球菌素抑菌机理及在食品保鲜中的研究进展[J]. 食品工业科技,2021,42(3):346−350. [WANG J Y, HU W Z, GUAN Y G, et al. Research progress on the bacteriostatic mechanism of nisin and its application in food preservation[J]. Science and Technology of Food Industry,2021,42(3):346−350. doi: 10.13386/j.issn1002-0306.2020040214
[2]	朱燕莉, 王正莉, 王卫, 等. 天然食品防腐剂的抑菌机理研究进展[J]. 中国调味品,2021,46(9):176−180. [ZHU Y L, WANG Z L, WANG W, et al. Research progress on antibacterial mechanism of natural food preservatives[J]. Chinese Condiment,2021,46(9):176−180. doi: 10.3969/j.issn.1000-9973.2021.09.034
[3]	FELICIO B A, PINTO M S, OLIVEIRA F S, et al. Effects of nisin on Staphylococcus aureus count and physicochemical properties of Minas Frescal cheese[J]. Journal of Dairy Science,2015,98(7):4364−4369. doi: 10.3168/jds.2015-9520
[4]	CHEN X R, ZHANG X W, MENG R Z, et al. Efficacy of a combination of nisin and p-anisaldehyde against Listeria monocytogenes[J]. Food Control,2016,66:100−106. doi: 10.1016/j.foodcont.2016.01.025
[5]	KUWANO K, TANAKA N, SHIMIZU T, et al. Dual antibacterial mechanisms of Nisin Z against Gram-positive and Gram-negative bacteria[J]. Int J Antimicrob Agents,2005,26(5):396−402. doi: 10.1016/j.ijantimicag.2005.08.010
[6]	SHIN J M, GWAK J W, KAMARAJAN P, et al. Biomedical applications of Nisin[J]. Journal of Applied Microbiology,2016,120(6):1449−1465. doi: 10.1111/jam.13033
[7]	SOBRINO L A, MARTÍN B O. Use of Nisin and other bacteriocins for preservation of dairy products[J]. International Dairy Journal,2008,18(4):329−343. doi: 10.1016/j.idairyj.2007.11.009
[8]	初晓东, 林宇恒, 孙志增, 等. 乳链菌肽(Nisin)抗性机制的研究进展[J]. 微生物学报,2010,50(9):1129−1134. [CHU X D, LIN Y H, SUN Z Z, et al. Advances in the study of Nisin resistance-A review[J]. Acta Microbiologica Sinica,2010,50(9):1129−1134. doi: 10.13343/j.cnki.wsxb.2010.09.002
[9]	黄可榆, 谢彩锋, 杭方学, 等. 乳酸链球菌素抗菌活性的改善及在食品保鲜中的研究进展[J]. 中国食品添加剂,2021,32(12):208−213. [HUANG K Y, XIE C F, HANG F X, et al. Research progress on the improvement of antibacterial activity of Nisin and its application in food preservation[J]. China Food Additives,2021,32(12):208−213. doi: 10.19804/j.issn1006-2513.2021.12.028
[10]	余楠楠, 陈琛. Nisin抗菌肽在食品抗菌防腐中的应用[J]. 食品研究与开发,2020,41(17):198−204. [YU N N, CHEN C. Application of nisin antibacterial peptide in food preservation[J]. Food Research and Development,2020,41(17):198−204. doi: 10.12161/j.issn.1005-6521.2020.17.032
[11]	郭娟, 张进, 王佳敏, 等. 天然抗菌剂在食品包装中的研究进展[J]. 食品科学,2021,42(9):336−346. [GUO J, ZHANG J, WANG J M, et al. Natural antibacterial agents and their application in food packaging: A review[J]. Food Science,2021,42(9):336−346. doi: 10.7506/spkx1002-6630-20200406-066
[12]	马天旗. 专利分析: 方法, 图表解读与情报挖掘[M]. 北京: 知识产权出版社, 2015: 1−8 MA T Q. Patent information analysis: Methods, patent-map interpretation and data mining[M]. Beijing: Intellectual Property Publishing House, 2015: 1−8.
[13]	钱文文, 辛宝, 马诚, 等. 基于专利分析羊乳产业创新热点及发展趋势[J]. 中国乳品工业,2022,50(3):48−52. [QIAN W W, XIN B, MA C, et al. Research on innovation hotspots and development trend of goat’s milk industry based on patent literatures analysis[J]. China Dairy Industry,2022,50(3):48−52. doi: 10.19827/j.issn1001-2230.2022.03.009
[14]	梁多, 王一凡. 利用“智慧芽”专利检索工具分析低脂食品研发专利情况[J]. 食品安全质量检测学报,2019,10(8):2420−2424. [LIANG D, WANG Y F. Analysis of low-fat food research and development patents by PatSnap[J]. Journal of Food Safety & Quality,2019,10(8):2420−2424. doi: 10.3969/j.issn.2095-0381.2019.08.051
[15]	张南. 食品安全快速检测技术的专利文献计量研究[J]. 食品科学,2019,40(1):334−340. [ZHANG N. Bibliometric study of patents on rapid food safety detection technologies[J]. Food Science,2019,40(1):334−340. doi: 10.7506/spkx1002-6630-20170819-240
[16]	赖燕娜, 马顺, 李莺, 等. 从专利申请看3D打印技术在食品工业中的应用进展[J]. 食品与机械,2018,34(1):163−166. [LAI Y N, MA S, LI Y, et al. Application progress of 3D printing technology in food industry from patent application[J]. Food & Machinery,2018,34(1):163−166. doi: 10.13652/j.issn.1003-5788.2018.01.033
[17]	KHAN I, OH D H. Integration of Nisin into nanoparticles for application in foods[J]. Innovative Food Science and Emerging Technologies,2016,34:376−384. doi: 10.1016/j.ifset.2015.12.013
[18]	赵正一. 我国食品安全法律制度研究[D]. 开封: 河南大学, 2013 ZHAO Z Y. The study of food safety law system in China[D]. Kaifeng: Henan University, 2013
[19]	陈峰, 李建平, 陈天鹏. 健康食品技术发展现状与趋势[J]. 中国食品学报,2015,15(5):1−10. [CHEN F, LI J P, CHEN T P. Current status and future trend of research and development for health foods[J]. Journal of Chinese Institute of Food Science and Technology,2015,15(5):1−10. doi: 10.16429/j.1009-7848.2015.05.001
[20]	王和勇, 古龙. 基于专利计量的人工智能发展现状研究及关键技术分析[J]. 科技管理研究,2020,40(21):202−210. [WANG H Y, GU L. Current research and key technology analysis of artificial intelligence based on patent measurement[J]. Science and Technology Management Research,2020,40(21):202−210. doi: 10.3969/j.issn.1000-7695.2020.21.026
[21]	马天旗. 专利布局[M]. 北京: 知识产权出版社, 2016: 1−7 MA T Q. Patent portfolio planning[M]. Beijing: Intellectual Property Publishing House, 2016: 1−7.
[22]	BAHRAMI A, DELSHADI R, JAFARI S M, et al. Nanoencapsulated Nisin: An engineered natural antimicrobial system for the food industry[J]. Trends in Food Science & Technology,2019,20(2):10−16.
[23]	曹云刚, 张瀚丹, 张鑫, 等. ε-聚赖氨酸抑菌机制及其在肉类保鲜中的应用[J]. 精细化工,2022,39(1):1−6,64. [CAO Y G, ZHANG H D, ZHANG X, et al. Antibacterial mechanism of ε-poly-L-lysine and its application in meat preservation[J]. Fine Chemicals,2022,39(1):1−6,64. doi: 10.13550/j.jxhg.20210722
[24]	张小敏, 郭全友, 周国燕, 等. 壳聚糖协同乳酸链球菌素抗轻腌大黄鱼源特定腐败菌抑制效应研究[J]. 中国食品学报,2022,22(5):259−270. [ZHANG X M, GUO Q Y, ZHOU G Y, et al. Inhibitory effect of chitosan and nisin on specific spoilage bacteria from lightly salted large yellow croaker[J]. Journal of Chinese Institute of Food Science and Technology,2022,22(5):259−270. doi: 10.16429/j.1009-7848.2022.05.028
[25]	杨立娜, 赵亚凡, 马丹丹, 等. Nisin及纳他霉素生物保鲜剂对干豆腐保鲜效果的研究[J]. 食品研究与开发,2020,41(10):21−27. [YANG L N, ZHAO Y F, MA D D, et al. Effect of Nisin and natamycin biological preservative on fresh-keeping of dried tofu[J]. Food Research and Development,2020,41(10):21−27. doi: 10.12161/j.issn.1005-6521.2020.10.004
[26]	李文江, 邱永涛. 中小企业利用失效专利创新发展探究[J]. 河南科技,2022,41(8):139−142. [LI W J, QIU Y T. Research on the innovation and development of small and medium-sized enterprises using invalid patents[J]. Henan Science and Technology,2022,41(8):139−142. doi: 10.19968/j.cnki.hnkj.1003-5168.2022.08.030
[27]	李有起. Nisin在食品防腐作用中的研究进展[J]. 食品研究与开发,2012,33(4):233−235. [LI Y Q. Application on food preservative effect of Nisin[J]. Food Research and Development,2012,33(4):233−235. doi: 10.3969/j.issn.1005-6521.2012.04.065
[28]	钟满喜. 一种即食风味酱板鱼: 中国, 201910289138.0[P]. 2019-7-12 ZHONG M X. Instant flavored spicy salted fish: CN, 201910289138.0[P]. 2019-07-12.
[29]	黄明, 汤春辉, 黄继超. 一种生鲜调理鸭胸肉产品及其生产工艺: 中国, 201210157803.9[P]. 2012-09-12 HUANG M, TANG C H, HUANG J C. Fresh conditioning duck breast meat product and production process thereof: CN, 201210157803.9[P]. 2012-09-12.
[30]	SUN Y E, LÜ G Q, LU Y T. Compound black fermented fruit wine and method for preparing the same: AU, 2021102610U[P]. 2021-07-08.
[31]	毛海霞, 毛怀彬. 无二氧化硫全汁发酵猕猴桃酒及其生产工艺: 中国, 201410390121.1[P]. 2014-11-05 MAO H X, MAO H B. Fermentation kiwi wine without sulfur dioxide whole juice and production process thereof: CN, 201410390121.1[P]. 2014-11-05.
[32]	崔俊锋, 苟轶群, 王强, 等. 一种醇香低盐蘸料及其制备方法: 中国, 201510531156.7[P]. 2016-01-06 CUI J F, GOU Y Q, WANG Q, et al. Mellow low salt sauce and preparation method thereof: CN, 201510531156.7[P]. 2016-01-06.
[33]	GHARSALLAOUI A, OULAHAL N, JOLY C, et al. Nisin as a food preservative: Part 1. Physicochemical properties, antimicrobial activity, and main uses[J]. Critical Reviews in Food Science and Nutrition,2016,56(8):1262−1274. doi: 10.1080/10408398.2013.763765
[34]	周涛, 王月红, 满文曾. 一种复合生物保鲜剂及其在醉螺防腐中的应用: 中国, 201810170581.1[P]. 2018-07-31 ZHOU T, WANG Y H, MAN W Z. Composite bio-preservation agent and its application in drunk screw anti-corrosion: CN, 201810170581.1[P]. 2018-07-31.
[35]	高程海, 米顺利, 易湘茜, 等. 一种海葡萄保鲜剂以及海葡萄保鲜的方法: 中国, 201711047804.7[P]. 2018-03-20 GAO C H, MI S L, YI X Q, et al. Fresh keeping agent of sea grapes and fresh keeping method of sea grapes: CN, 201711047804.7[P]. 2018-03-20.
[36]	莫树平, 吴清平, 柏建玲, 等. 一种生鲜肉类复合生物防腐剂及其制备方法: 中国, 201210146766.1[P]. 2012-08-22 MO S G, WU Q P, BAI J L, et al. Fresh meat composite biological preservative and its preparation method: CN, 201210146766.1[P]. 2012-08-22.
[37]	SHEEHAN V, CHENG Y, COOPER R, et al. Composition and methods to control the outgrowth of pathogens and spoilage microorganisms in high moisture and low sodium systems: US, 15/097922[P]. 2018-02-08.
[38]	LEISTNER L. Basic aspects of food preservation by hurdle technology[J]. International Jourmal of Food Microbiology,2000,55(1):181−186.
[39]	曹宏, 高美须, 杨宏玉, 等. 一种盒装风味畜禽制品辐照保质方法: 中国, 201510465669.2[P]. 2015-11-11 CAO H, GAO M X, YANG H Y, et al. Irradiation and quality assurance method for boxed flavored livestock and poultry products: CN, 201510465669.2[P]. 2015-11-11.
[40]	MOON S Y, KANG D I, KIM S K, et al. Method for producing vegetable products using ultra high pressure: EP, 2014832766[P]. 2015-02-05.
[41]	李晓东, 任红晶, 张华, 等. 加压二氧化碳和三种天然抑菌剂对液体食品中芽孢的协同杀菌方法: 中国, 201310741702.0[P]. 2014-05-07 LI X D, REN H J, ZHANG H, et al. Synergistic sterilization method of pressurized carbon dioxide and three natural bacteriostatic agents for spores in liquid food: CN, 201310741702.0[P]. 2014-05-07.
[42]	邓尚贵, 应晓国. 一种延长冰鲜水产货架期的方法: 中国, 202110637535. X[P]. 2021-08-17 DENG S G, YING X G. Method for prolonging shelf life of chilled fresh aquatic products: CN, 202110637535. X[P]. 2021-08-17.
[43]	肖凯军, 郑必胜, 梁华鹏, 等. 粤菜软包装保藏方法: 中国, 02115196.2[P]. 2002-11-06 XIAO K J, ZHENG B S, LIANG H P, et al. Preserving method for soft package of Guangdong dishes: CN, 02115196.2[P]. 2002-11-06.
[44]	项文诚. 一种羊肉产品气调包装方法: 中国, 201610995067.2[P]. 2017-05-10 XIANG W C. Modified atmosphere packaging method of lamb products: CN, 201610995067.2[P]. 2017-05-10.
[45]	AASEN I M, MARKUSSEN S, MØRETRØ T, et al. Interactions of the bacteriocins sakacin P and nisin with food constituents[J]. International Journal of Food Microbiology,2003,87:35−43. doi: 10.1016/S0168-1605(03)00047-3
[46]	MALHEIROS P S, DAROIT D J, BRANDELLI A. Food applications of liposome-encapsulated antimicrobial peptides[J]. Trends in Food Science & Technology,2010,21:284−292.
[47]	吴娟. 负载Nisin聚谷氨酸/壳聚糖纳米粒子的明胶纤维膜制备及其在奶酪贮藏中的应用[D]. 镇江: 江苏大学, 2017 WU J. Preparation of Nisin-loaded γ-PGA/chitosan nanoparticles-embedded gelatin nanofiber film and its application on cheese during storage[D]. Zhenjing: Jiangsu University, 2017.
[48]	乔建军, 李晨辰, 宋倩倩, 等. 一种Nisin热敏脂质体及其制备方法和应用: 中国, 201810387040.4[P]. 2018-10-19 QIAO J J, LI C C, SONG Q Q, et al. Nisin thermosensitive liposome and preparation method thereof and application: CN, 201810387040.4[P]. 2018-10-19.
[49]	饶胜其, 陆湘宁, 杨振泉, 等. 一种蛋清蛋白-Nisin纳米粒子抗菌剂制备方法: 中国, 202010902240.6[P]. 2020-12-08 RAO S Q, LU X N, YANG Z Q, et al. Preparation method of egg white protein-Nisin nanoparticle antibacterial agent: CN, 201810387040.4[P]. 2018-10-19.
[50]	刘伟, 王志东, 张洁, 等. 适用于果汁加工的天然抑菌性食品添加剂及其制备方法: 中国, 201610617899.0[P]. 2017-01-04 LIU W, WANG Z D, ZHANG J, et al. Natural bacteriostatic food additive for juice processing and preparation method therefor: CN, 201610617899.0[P]. 2017-01-04.
[51]	GONG J Y, XIAO G N, YUAN H N, et al. Sodium alginate chitosan microcapsule containing polylisine and Nisin and preparation method therefor: NL, 2026059[P]. 2020-09-04.
[52]	王利娜, 冷小京. 可食性抗菌膜的研究进展[J]. 食品科技,2011,36(10):97−101. [WANG L N, LENG X J. Research and development of antimicrobial edible film[J]. Food Science and Technology,2011,36(10):97−101. doi: 10.13684/j.cnki.spkj.2011.10.057
[53]	黄艳凤, 张平, 马骏. 一种纳米生物果蔬涂被剂及其制备方法: 中国, 200910228527.9[P]. 2010-06-02 HUANG Y F, ZHANG P, MA J. Nano biological fruits and vegetables coating agent and preparation method thereof: CN, 200910228527.9[P]. 2010-06-02.
[54]	罗欣, 张希斌. 一种使用可食性明胶抑菌涂层保鲜生鲜调理肉制品的方法: 中国, 201010181167.4[P]. 2010-09-15 LUO X, ZHANG X B. Method for refreshing and conditioning fresh meat product by using edible gelatine bacteriostatic coating: CN, 201010181167.4[P]. 2010-09-15.
[55]	王志东, 刘伟, 张洁, 等. 适用于柑橘保鲜的生物可降解活性复合膜的制备方法: 中国, 201610671204.7. 2017-01-04 WANG Z D, LIU W, ZHANG J, et al. Preparation method of biodegradable active composite membrane suitable for preserving freshness of citruses: CN, 201610671204.7[P]. 2017-01-04.
[56]	邢亚阁, 余帅, 张琦, 等. 泡菜块茎类原料生物源双相涂膜保鲜剂的制备方法: 中国, 201110377272. X[P]. 2012-04-11 XING Y G, YU S, ZHANG Q, et al. Method for preparing biogenic biphase coating anti-staling agent for pickle stem tuber raw materials: CN, 201110377272. X[P]. 2012-04-11.
[57]	林娟, 苏冰梅, 陈江平, 等. 一种应用于超市生鲜猪肉保鲜的可食性复合保鲜膜: 中国, 201210508168.4[P]. 2013-03-20 LIN J, SU B M, CHEN J P, et al. Edible composite preservative film applied to preservation of fresh pork in supermarket: CN, 201210508168.4[P]. 2013-03-20.
[58]	WU Y Z, LI Z, LU Y M. Gelatin base edible film and preparation method thereof: US, 16/393717[P]. 2019-08-15.

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[8]	SHI Xuan, CHENG Xiao-qing, YANG Yong, TAN Hong-jun, LIANG Xu-ming, SHI Wen-juan, SU Zhi-min. Optimization the extraction process of polysaccharide by response surface methodology from the Tremella fuciformis pedicel and its antioxidant activity[J]. Science and Technology of Food Industry, 2017, (02): 297-301. DOI: 10.13386/j.issn1002-0306.2017.02.049
[9]	GONG Jian. Study on the optimization of enzymatic extraction technology of polysaccharide from Camellia japonica L.by response surface methodology and investigation on its antioxidant activity[J]. Science and Technology of Food Industry, 2015, (17): 197-201. DOI: 10.13386/j.issn1002-0306.2015.17.031
[10]	KE Chun-lin, LI Zuo-mei, LU Bin-yu, QIAN Shi-quan, ZHANG Bin, YUAN Jing. Study on optimization of extraction conditions for polysaccharide from pomegranate flowers and its antioxidant activities[J]. Science and Technology of Food Industry, 2015, (08): 286-289. DOI: 10.13386/j.issn1002-0306.2015.08.051