Phytochemical Composition and <i>α</i>-Glucosidase Inhibitory Activity of <i>Campanumoea lancifolia</i> (Roxb.) Merr Fruit

HUANG Chunyue; MA Mengjie; NIU Lixin; JIN Jianjie; WU Man; TIAN Bei; HU Xiao

doi:10.13386/j.issn1002-0306.2021110169

Volume 43 Issue 16

Aug. 2022

Turn off MathJax

Article Contents

Abstract

References

Science and Technology of Food Industry > 2022 > 43(16): 65-73. > DOI: 10.13386/j.issn1002-0306.2021110169

HUANG Chunyue, MA Mengjie, NIU Lixin, et al. Phytochemical Composition and α-Glucosidase Inhibitory Activity of Campanumoea lancifolia (Roxb.) Merr Fruit[J]. Science and Technology of Food Industry, 2022, 43(16): 65−73. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021110169.

Citation:

PDF (3672 KB)

Phytochemical Composition and α-Glucosidase Inhibitory Activity of Campanumoea lancifolia (Roxb.) Merr Fruit

HUANG Chunyue^{1, 2,},
MA Mengjie^{1, 2},
NIU Lixin^{1, 2},
JIN Jianjie^{1, 2},
WU Man^{1, 2},
TIAN Bei³,
HU Xiao^{1, 2, ,}

1.
China State Institute of Pharmaceutical Industry, Shanghai 201203, China
2.
State Key Lab. of New Drug and Pharmaceutical Progress, Shanghai Institute of Pharmaceutical Industry Co., Ltd., Shanghai 201203, China
3.
Guizhou Innovation Agriculture Development Co., Ltd., Tongren 554300, China

More Information

Received Date: November 15, 2021
Available Online: June 14, 2022

Graphical Abstract

Abstract

Abstract

Hong Guo Shen Guo (HGSG) are the fruits of Campanumoea lancifolia (Roxb.) Merr, which are mainly cultivated in Southwest China. This study was to investigate the ingredients from HGSG extracts and their α-glucosidase inhibition in vitro. The contents of polysaccharide, total flavonoids, total anthocyanins and total phenols in extracts from HGSG were measured using UV spectrophotometry. Chemical ingredients were further analyzed applying ultra-high performance liquid chromatography-time of flight-tandem mass spectrometry (UPLC-QTOF-MS). The results showed that the content of crude polysaccharide in five batches of HGSG was 27.59%~37.59%. The total flavone content of ethanol extract was 1.22%~1.77%, the total anthocyanin content was 0.90%~1.14%, and the total polyphenol content was 13.11%~18.85%. Twenty one compounds were identified from HGSG, including 10 flavonoids, 3 phenolic acids, 3 organic acids, 3 anthocyanins, 1 amino acid and 1 polyacetylene. The ethanol extract, crude polysaccharide and luteolin of HGSG exhibited potent α-glucosidase inhibitory activities with IC₅₀ values of 7.52, 37.43 and 8.03 μg/mL, respectively, which were significantly higher than that of acarbose (616.17 μg/mL). This study preliminarily defined the material basis of HGSG, and reported for the first time that HGSG had potential anti diabetes activity, which would provide a theoretical reference for the development and utilization of HGSG.

FullText(HTML)

References (55)

References

[1]	FAN W. Epidemiology in diabetes mellitus and cardiovascular disease[J]. Cardiovascular Endocrinology,2017,6(1):8−16. doi: 10.1097/XCE.0000000000000116
[2]	SAEEDI P, PETERSOHN I, SALPEA P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the international diabetes federation diabetes atlas, 9th edition[J]. Diabetes Research and Clinical Practice,2019,157:107843. doi: 10.1016/j.diabres.2019.107843
[3]	WHO. Global Report on Diabetes[EB/OL]. Available online:http://www.who.int/diabetes/global-report/en/(accessed on 15 July 2016).
[4]	于彩云, 高兆兰, 陈天资, 等. 天然产物中α-葡萄糖苷酶抑制剂的研究进展[J]. 食品工业科技,2015,36(22):394−399. [YU Caiyun, GAO Zhaolan, CHEN Tianzi, et al. Advancement in research of α-glucosidase inhibitors of natural products[J]. Science and Technology of Food Industry,2015,36(22):394−399. YU Caiyun, GAO Zhaolan, CHEN Tianzi, et al. Advancement in research of α-glucosidase inhibitors of natural products[J]. Science and Technology of Food Industry, 2015, 36(22): 394-399.
[5]	阎成炟, 郭崇真, 林建阳, 等. 新型α-葡萄糖苷酶抑制剂筛选及药理作用研究进展[J]. 药物评价研究,2021,44(2):440−445. [YAN Chengda, GUO Chongzhen, LIN Jianyang, et al. Research progress of screen and pharmacological effect for novel α-glucosidase[J]. Drug Evaluation Research,2021,44(2):440−445. YAN Chengda, GUO Chongzhen, LIN Jianyang, et al. Research progress of screen and pharmacological effect for novel α-glucosidase[J]. Drug Evaluation Research, 2021, 44(2): 440-445.
[6]	季涛, 宿树兰, 郭盛, 等. 基于α-葡萄糖苷酶抑制活性评价桑叶多组分药效相互作用研究[J]. 中国中药杂志,2016(11):1999−2006. [JI Tao, SU Shulan, GUO Sheng, et al. Evaluate drug interaction of multi-components in Morus alba leaves based on α-glucosidase inhibitory activity[J]. China Journal of Chinese Materia Medica,2016(11):1999−2006. JI Tao, SU Shulan, GUO Sheng, et al. Evaluate drug interaction of multi-components in morus alba leaves based on α-glucosidase inhibitory activity[J]. China Journal of Chinese Materia Medica, 2016(11): 1999-2006.
[7]	RYU H, LEE B, CURTIS-LONG M, et al. Polyphenols from Broussonetia papyrifera displaying potent α-glucosidase inhibition[J]. Journal of Agricultural and Food Chemistry,2010,58(1):202−208. doi: 10.1021/jf903068k
[8]	乔锦莉, 张妍, 刘佩, 等. 野生蓝果忍冬多酚鉴定及其抗氧化、降血糖活性[J]. 食品科学,2021,42(11):47−55. [QIAO Jinli, ZHANG Yan, LIU Pei, et al. Polyphenol composition and antioxidant and hypoglycemic activities in wild blue honeysuckle fruit[J]. Food Science,2021,42(11):47−55. doi: 10.7506/spkx1002-6630-20200709-123 QIAO Jinli, ZHANG Yan, LIU Pei, et al. Polyphenol composition and antioxidant and hypoglycemic activities in wild blue honeysuckle fruit[J]. Food Science, 2021, 42(11): 47-55. doi: 10.7506/spkx1002-6630-20200709-123
[9]	AURIANE D, NAWEL B, TRISTAN R, et al. α-Glucosidase inhibitory activity of tannat grape phenolic extracts in relation to their ripening stages[J]. Biomolecules,2020,10(8):1088. doi: 10.3390/biom10081088
[10]	JIANG Z D, YU G, LIANG Y, et al. Inhibitory effects of a sulfated polysaccharide isolated from edible red alga Bangiafusco-purpurea on α-amylase and α-glucosidase[J]. Bioscience, Biotechnology, and Biochemistry,2019,83(11):2065−2074. doi: 10.1080/09168451.2019.1634515
[11]	CAO C L, HUANG Q, ZHANG B, et al. Physicochemical characterization and in vitro hypoglycemic activities of polysaccharides from Sargassum pallidum by microwave-assisted aqueous two-phase extraction[J]. International Journal of Biological Macromolecules,2018,109:357−368. doi: 10.1016/j.ijbiomac.2017.12.096
[12]	CAO X, XIA Y, LIU D, et al. Inhibitory effects of Lentinus edodes mycelia polysaccharide on α- glucosidase, glycation activity and high glucose-induced cell damage[J]. Carbohydrate Polymers,2020,246:116659. doi: 10.1016/j.carbpol.2020.116659
[13]	PROENÇA C, FREITAS M, RIBEIRO D, et al. α-Glucosidase inhibition by flavonoids: An in vitro and in silico structure-activity relationship study[J]. Journal of Enzyme Inhibition and Medicinal Chemistry,2017,32(1):1216−1228. doi: 10.1080/14756366.2017.1368503
[14]	PENG X, ZHANG G, LIAO Y, et al. Inhibitory kinetics and mechanism of kaempferol on α-glucosidase[J]. Food Chemistry,2016,190:207−215. doi: 10.1016/j.foodchem.2015.05.088
[15]	郅丽超, 张琳依, 梁馨元, 等. 天然活性成分对α-葡萄糖苷酶抑制作用的研究进展[J]. 食品安全质量检测学报,2021,12(6):2276−2282. [ZHI Lichao, ZHANG Linyi, LIANG Xinyuan, et al. Research progress on the inhibitory effect of natural active ingredients on α-glucosidase[J]. Journal of Food Safety and Quality,2021,12(6):2276−2282. ZHI Lichao, ZHANG Linyi, LIANG Xinyuan, et al. Research progress on the inhibitory effect of natural active ingredients on α-glucosidase[J]. Journal of Food Safety and Quality, 2021, 12(6): 2276-2282.
[16]	陈慧, 熊磊, 王文君. 植物次生代谢产物来源的α-葡萄糖苷酶抑制剂研究进展[J]. 中国中药杂志,2017,42(15):2915−2924. [CHEN Hui, XIONG Lei, WANG Wenjun. Reviews on α-glucosidase inhibitor from plant secondary metabolites[J]. China Journal of Chinesemateria Medica,2017,42(15):2915−2924. CHEN Hui, XIONG Lei, WANG Wenjun. Reviews on α-glucosidase inhibitor from plant secondary metabolites[J]. China Journal of Chinesemateria Medica, 2017, 42(15): 2915-2924.
[17]	ZHANG J, SUN L, DONG Y, et al. Chemical compositions and α-glucosidase inhibitory effects of anthocyanidins from blueberry, blackcurrant and blue honeysuckle fruits[J]. Food Chemistry,2019,299:125102. doi: 10.1016/j.foodchem.2019.125102
[18]	LI R, WANG Q, ZHAO M, et al. Flavonoid glycosides from seeds of Hippophae rhamnoides subsp. sinensis with alpha-glucosidase inhibition activity[J]. Fitoterapia,2019,137:104248. doi: 10.1016/j.fitote.2019.104248
[19]	南京中医药大学. 中药大辞典[M]. 上海: 上海科学技术出版社, 2006: 1397-1398 Nanjing University of Chinese Medicine. Chinese materia medica dictionary[M]. Shanghai: Shanghai Scientific & Technical Literature Publishers, 2006: 1397-1398.
[20]	陈雅, 李贵, 吴帅玲, 等. 红果参叶中总黄酮的提取工艺初步探讨[J]. 中国野生植物资源,2014,33(2):24−27. [CHEN Ya, LI Gui, WU Shuailing, et al. Preliminary discussion on extration of total flavonids from the leaves of “Hong Guoshen” plant[J]. Chinese Wild Plant Resources,2014,33(2):24−27. doi: 10.3969/j.issn.1006-9690.2014.02.007 CHEN Ya, LI Gui, WU Shuailing, et al. Preliminary discussion on extration of total flavonids from the leaves of “Hong Guoshen” plant[J]. Chinese Wild Plant Resources, 2014, 33(2): 24-27. doi: 10.3969/j.issn.1006-9690.2014.02.007
[21]	陈莉华, 王晓静, 肖琴, 等. 红果参果胶提取物的抗氧化作用研究[J]. 食品工业科技,2015,36(4):143−146. [CHEN Lihua, WANG Xiaojing, XIAO Qin, et al. Study on antioxidant activities of pectin from Hong Guo ginseng[J]. Science and Technology of Food Industry,2015,36(4):143−146. CHEN Lihua, WANG Xiaojing, XIAO Qin, et al. Study on antioxidant activities of pectin from Hong Guo ginseng[J]. Science and Technology of Food Industry, 2015, 36(4): 143-146.
[22]	陈莉华, 龙进国, 谭林艳, 等. 红果参多糖的提取纯化及抗氧化活性研究[J]. 天然产物研究与开发,2013,25:170−173. [CHEN Lihua, LONG Jinguo, TAN Linyan, et al. Extraction and purification of polysaccharides from Hong Guo ginseng and the comparison of antioxidant activity[J]. Natural Product Research and Development,2013,25:170−173. doi: 10.3969/j.issn.1001-6880.2013.02.005 CHEN Lihua, LONG Jinguo, TAN Linyan, et al. Extraction and purification of polysaccharides from Hong Guo ginseng and the comparison of antioxidant activity[J]. Natural Product Research and Development, 2013, 25: 170-173. doi: 10.3969/j.issn.1001-6880.2013.02.005
[23]	李斌, 李贵, 陈功锡, 等. 红果参果实多糖的提取及其单糖组分研究[J]. 亚热带植物科学,2015,44(1):13−17. [LI Bin, LI Gui, CHEN Gongxi, et al. Extraction and composition of polysaccharide from the fruits of Campnumoea lancifolia[J]. Subtropical Plant Science,2015,44(1):13−17. doi: 10.3969/j.issn.1009-7791.2015.01.003 LI Bin, LI Gui, CHEN Gongxi, et al. Extraction and composition of polysaccharide from the fruits of Campnumoea lancifolia[J]. Subtropical Plant Science, 2015, 44(1): 13-17. doi: 10.3969/j.issn.1009-7791.2015.01.003
[24]	王晓静, 陈莉华, 莫宇婷. 红果参黄酮与V_C的协同抗氧化活性[J]. 食品发酵与工业,2014,40(12):111−115. [WANG Xiaojing, CHEN Lihua, MO Yuting. Cooperative antioxidant effects of flavonoids from Hong Guo ginseng and V_C[J]. Food and Fermentation Industries,2014,40(12):111−115. WANG Xiaojing, CHEN Lihua, MO Yuting. Cooperative antioxidant effects of flavonoids from Hong Guo ginseng and V_C[J]. Food and Fermentation Industries, 2014, 40(12): 111-115.
[25]	XIANG Z, LIN C, ZHU Y, et al. Phytochemical profiling of antioxidative polyphenols and anthocyanins in the wild plant Campanumoea lancifolia (Roxb. ) Merr[J]. International Journal of Food Propertise,2021,24(1):105−114. doi: 10.1080/10942912.2020.1867570
[26]	宛美志, 孟宪军. 蔓越莓花色苷的组成鉴定及抗氧化能力[J]. 食品科学,2018,39(22):45−50. [WAN Meizhi, MENG Xianjun. Anthocyanin composition and antioxidant activity of cranberry[J]. Food Science,2018,39(22):45−50. doi: 10.7506/spkx1002-6630-201822008 WAN Meizhi, MENG Xianjun. Anthocyanin composition and antioxidant activity of cranberry[J]. Food Science, 2018, 39(22): 45-50. doi: 10.7506/spkx1002-6630-201822008
[27]	邓菊庆, 柏春玲, 杨学芳, 等. 紫外可见分光光度法测定不同品种柑橘皮中总黄酮含量[J]. 安徽农业科学,2020,48(9):210−211,252. [DENG Juqing, BAI Chunling, YANG Xuefang, et al. Determination of total flavonoids in different varieties of citrus peels by ultraviolet-visible spectrophotometry[J]. Journal of Anhui Agricultural Sciences,2020,48(9):210−211,252. doi: 10.3969/j.issn.0517-6611.2020.09.058 DENG Juqing, BAI Chunling, YANG Xuefang, et al. Determination of total flavonoids in different varieties of citrus peels by ultraviolet-visible spectrophotometry[J]. Journal of Anhui Agricultural Sciences, 2020, 48(9): 210-211, 252. doi: 10.3969/j.issn.0517-6611.2020.09.058
[28]	王艺菲, 辛秀兰, 陈亮, 等. pH示差法测定不同种类蓝果忍冬总花色苷含量[J]. 食品研究与开发,2014,35(7):75−77. [WANG Yifei, XIN Xiulan, CHEN Liang, et al. Total anthocyanins content in different species of Lonicera cearulea Linn. by pH-differential spectrophotometry[J]. Food Research and Development,2014,35(7):75−77. doi: 10.3969/j.issn.1005-6521.2014.07.021 WANG Yifei, XIN Xiulan, CHEN Liang, et al. Total anthocyanins content in different species of Lonicera cearulea Linn. by pH-differential spectrophotometry[J]. Food Research and Development, 2014, 35(7): 75-77. doi: 10.3969/j.issn.1005-6521.2014.07.021
[29]	王凤娟, 孙飞龙, 叶文文, 等. pH示差法测定红菊苣中花青素条件的优化[J]. 包装与食品机械,2018,36(5):61−64. [WANG Fengjuan, SUN Feilong, YE Wenwen, et al. Optimization of analytical conditions for determining content of anthocyanin in Cichoricum intybus Var. Foliosum Hegi by pH differential method[J]. Packaging and Food Machinery,2018,36(5):61−64. doi: 10.3969/j.issn.1005-1295.2018.05.012 WANG Fengjuan, SUN Feilong, YE Wenwen, et al. Optimization of analytical conditions for determining content of anthocyanin in Cichoricum intybus Var. Foliosum Hegi by pH differential method[J]. Packaging and Food Machinery, 2018, 36(5): 61-64. doi: 10.3969/j.issn.1005-1295.2018.05.012
[30]	VEGA A J D, HECTOR R E, JOSE L G J, et al. Effect of solvents and extraction methods on total anthocyanins, phenolic compounds and antioxidant capacity of Renealmia alpinia (Rottb.) Maas peel[J]. Czech Journal of Food Sciences,2017,35(5):456−465. doi: 10.17221/316/2016-CJFS
[31]	JIANG T, MAO Y, SUI L, et al. Degradation of anthocyanins and polymeric color formation during heat treatment of purple sweet potato extract at different pH[J]. Food Chemistry,2019,274:460−470. doi: 10.1016/j.foodchem.2018.07.141
[32]	谭晓舒, 吴建文, 梨贵卿, 等. 火麻仁油总酚含量福林酚测定法的优化[J]. 食品研究与开发,2021,42(2):166−173. [TAN Xiaoshu, WU Jianwen, LI Gui-qing, et al. Optimization of folin-ciocalteu method for the determination of total polyphenols in hemp seed oil[J]. Food Research and Development,2021,42(2):166−173. TAN Xiaoshu, WU Jianwen, LI Gui-qing, et al. Optimization of folin-ciocalteu method for the determination of total polyphenols in hemp seed oil[J]. Food Research and Development, 2021, 42(2): 166-173.
[33]	GOKHAN Z H. A study on in vitro enzyme inhibitory properties of asphodelineanatolica: New sources of natural inhibitors for public health problems[J]. Industrial Crops and Products,2016,83:39−43. doi: 10.1016/j.indcrop.2015.12.033
[34]	卫强, 纪小影, 徐飞, 等. 木槿叶化学成分及抑制α-葡萄糖苷酶活性研究[J]. 中药材,2015,38(5):975−979. [WEI Qiang, JI Xiaoying, XU Fei, et al. Chemical constituents from leaves of Hibiscus syriacus and their α-glucosidase inhibitory activities[J]. Journal of Chinese Medicinal Materials,2015,38(5):975−979. WEI Qiang, JI Xiaoying, XU Fei, et al. Chemical constituents from leaves of Hibiscus syriacus and their α-glucosidase inhibitory activities[J]. Journal of Chinese Medicinal Materials, 2015, 38(5): 975-979.
[35]	范金波, 蔡茜彤, 冯叙桥, 等. 桑葚、蓝莓、黑加仑中多酚类物质的抗氧化活性[J]. 食品与发酵工业,2015,41(2):157−162. [FAN Jinbo, CAI Xitong, FENG Xuqiao, et al. Phenolic content and antioxidant capacity of blueberry, mulberry and blackcurrant[J]. Food and Fermention Industries,2015,41(2):157−162. FAN Jinbo, CAI Xitong, FENG Xuqiao, et al. Phenolic content and antioxidant capacity of blueberry, mulberry and blackcurrant[J]. Food and Fermention Industries, 2015, 41(2): 157-162.
[36]	张上上, 郑姝宁, 王学涛, 等. 超高效液相色谱-飞行时间-串联质谱法对3种蓝靛果忍冬果实中花青苷的比较分析[J]. 食品科学,2020,41(20):256−262. [ZHANG Shangshang, ZHENG Shuning, WANG Xuetao, et al. Comparative analysis of anthocyanins in the fruits of three varieties of blue honeysuckle (Lonicera caerulea L.) by ultra-high performance liquid chromatography-time of flight-tandem mass spectrometry[J]. Food Science,2020,41(20):256−262. doi: 10.7506/spkx1002-6630-20190822-223 ZHANG Shangshang, ZHENG Shuning, WANG Xuetao, et al. Comparative analysis of anthocyanins in three Lonicera edulis fruits by ultra high performance liquid chromatography time of flight tandem mass spectrometry[J]. Food Science, 2020, 41(20): 256-262. doi: 10.7506/spkx1002-6630-20190822-223
[37]	SARAVANAKUMAR K, PARK S J, MARIADOSS A V A, et al. Chemical composition, antioxidant, and anti-diabetic activities of ethyl acetate fraction of Stachys riederi var. japonica (Miq.) in streptozotocin-induced type 2 diabetic mice[J]. Food and Chemical Toxicology,2021,155:112374. doi: 10.1016/j.fct.2021.112374
[38]	CORRALES G, FERNANDEZ-MAYORALAS A, GARCIA-JUNCEDA E, et al. A new strategy for liquid-phase synthesis of disaccharides based on the use of glycosidases[J]. Biocatalysis and Biotransformation,2000,18(4):271−281. doi: 10.3109/10242420009015250
[39]	SIOMH S, ZAINAL A. Chemical profiling of Curcuma aeruginosa Roxb. rhizome using different techniques of solvent extraction[J]. Asian Pacific Journal of Tropical Biomedicine,2015,5(5):412−417. doi: 10.1016/S2221-1691(15)30378-6
[40]	GUORUOLUO Y, ZHOU H, WANG W, et al. Chemical constituents from the immature buds of Cinnamomum cassia (Lauraceae)[J]. Biochemical Systematics and Ecology,2018,78:102−105. doi: 10.1016/j.bse.2018.04.008
[41]	OLENNIKOV D N, KASHCHENKO N I. New flavonoids and turkesterone-2-O-cinnamate from leaves of Rhaponticum uniflorum[J]. Chemistry of Natural Compounds,2019,55(2):256−264. doi: 10.1007/s10600-019-02662-2
[42]	HU X, CHEN L, SHI S, et al. Antioxidant capacity and phenolic compounds of Lonicera macranthoides by HPLC-DAD-QTOF-MS/MS[J]. Journal of Pharmaceutical and Biomedical Analysis,2016,124:254−260. doi: 10.1016/j.jpba.2016.03.008
[43]	KOLEY T K, KHAN Z, OULKAR D, et al. Profiling of polyphenols in phalsa (Grewia asiatica L.) fruits based on liquid chromatography high resolution mass spectrometry[J]. Journal of Food Science and Technology,2020,57(2):606−616. doi: 10.1007/s13197-019-04092-y
[44]	NOUI A, BOUDIAR T, BAKHOUCHE A, et al. Chemical characterization of polyphenols from Daucus muricatus growing in Algeria by RP-UHPLC-ESI-QTOF-MS/MS[J]. Natural Product Research,2018,32(8):982−986. doi: 10.1080/14786419.2017.1371162
[45]	SIRICHAI A, SIRINTORN Y, PIYAWAN C, et al. Cyanidin-3-rutinoside alleviates postprandial hyperglycemia and its synergism with acarbose by inhibition of intestinal α-glucosidase[J]. Journal of Clinical Biochemistry and Nutrition,2011,49:36−41. doi: 10.3164/jcbn.10-116
[46]	TSUBASA T, SHO N, MASAKI K, et al. Delphinidin 3-rutinoside-rich blackcurrant extract ameliorates glucose tolerance by increasing the release of glucagon-like peptide-1secretion[J]. Food Science Nutrition,2017,5:929−933. doi: 10.1002/fsn3.478
[47]	朱晓丹, 江冰洁, 刘新元, 等. 天然产物中黄酮多酚及生物碱类化合物治疗2型糖尿病研究进展[J]. 中国现代中药,2019,21(11):1592−1598. [Zhu Xiaodan, JIANG Bingjie, Liu Xinyuan, et al. Mechanism and research progress of flavonoids, polyphenols and alkaloids in natural products for type 2 diabetes mellitus[J]. Modern Chinese Medicine,2019,21(11):1592−1598. Zhu Xiaodan, JIANG Bingjie, Liu Xinyuan, et al. Mechanism and research progress of flavonoids, polyphenols and alkaloids in natural products for type 2 diabetes mellitus[J]. Modern Chinese Medicine, 2019, 21(11): 1592-1598.
[48]	YAN J, ZHANG G, PAN J, et al. α-Glucosidase inhibition by luteolin: Kinetics, interaction andmolecular docking[J]. International Journal of Biological Macromolecules,2014,64:213−223. doi: 10.1016/j.ijbiomac.2013.12.007
[49]	SUN L, MIAO M. Dietary polyphenols modulate starch digestion and glycaemic level: A review[J]. Critical Reviews in Food Science and Nutrition,2020,60(4):541−555. doi: 10.1080/10408398.2018.1544883
[50]	YOON I S, CHO S S. Effects of lobetyolin on xanthine oxidase activity in vitro and in vivo: Weak and mixed inhibition[J]. Natural Product Research,2021,35(10):1667−1670. doi: 10.1080/14786419.2019.1622108
[51]	WU T, LUO J, XU B. In vitro antidiabetic effects of selected fruits and vegetables against glycosidase and aldose reductase[J]. Food Science & Nutrition,2015,3(6):495−505.
[52]	WANG Y, XIANG L, WANG C, et al. Antidiabetic and antioxidant effects and phytochemicals of mulberry fruit (Morus alba L.) polyphenol enhanced extract[J]. Plos One,2013,8(7):e71144. doi: 10.1371/journal.pone.0071144
[53]	FU X, YANG H, MA C, et al. Characterization and inhibitory activities on α-amylase and α-glucosidase of the polysaccharide from blue honeysuckle berries[J]. International Journal of Biological Macromolecules,2020,163:414−422. doi: 10.1016/j.ijbiomac.2020.06.267
[54]	石碧, 狄莹. 植物多酚[M]. 北京: 科学出版社, 2002: 5-30 SHI Bi, DI Ying. Plant polyphenols[M]. Beijing: Science Press, 2002: 5-30.
[55]	PROENC C, RIBEIRO D, FREITAS M, et al. Flavonoids as potential agents in the management of type 2 diabetes through the modulation of a-amylase and a-glucosidase activity: A review[J]. Critical Reviews in Food Science and Nutrition,2020:1−71.

[1]	MA Tian-xiao, YIN Zhen-hua, ZHANG Cui-li, LIU Hui-li, ZHANG Jin-xiang, GUO Wei-wei, CHEN Lin. Extraction and Separation,Physicochemical Characteristic and α-Glucosidase Inhibitory Activity in Vitro of Polysaccharides from Chionanthus retusus Lindl.et Paxt.Seed[J]. Science and Technology of Food Industry, 2020, 41(24): 64-68,80. DOI: 10.13386/j.issn1002-0306.2020070016
[2]	LI Yan-min, YU Shu-huai, TONG Yan-jun, YANG Rui-jin, ZHAO Wei. Preparation of α-Glucosidase Inhibitory Peptides Derived from Sea Mustard[J]. Science and Technology of Food Industry, 2020, 41(20): 127-134. DOI: 10.13386/j.issn1002-0306.2020.20.021
[3]	ZOU Rong-can, WU Shao-jin, JIAO Si-qi, FENG Chun, YU Zheng-wen. Antioxidant Activity and α-Glucosidase Inhibitory Activity of Cyclocarya paliurus Polysaccharides from Different Regions[J]. Science and Technology of Food Industry, 2018, 39(22): 25-29. DOI: 10.13386/j.issn1002-0306.2018.22.006
[4]	YU Li-na, DU De-hong, ZHANG Chu-shu, BI Jie, WANG Ming-qing, JIANG Chen, YANG Qing-li, PENG Ya-ping, YANG Zhen, SUN Jie. Optimization of preparation process of α-glucosidase inhibitory activity peptide with microwave assisted enzymatic hydrolysis reaction by response surface methodology[J]. Science and Technology of Food Industry, 2018, 39(4): 117-122,136.
[5]	TONG Shi-sheng, HU Jin-rong, ZHANG Jing-sheng, DONG Wen-xia, WANG Li, LIU Ping. Effects of four kinds of proteases on α-glucosidase inhibitory activity of polysaccharide from Inonotus obliquus[J]. Science and Technology of Food Industry, 2017, (14): 162-166. DOI: 10.13386/j.issn1002-0306.2017.14.032
[6]	YANG Wen-kang, LI Chao, YU Ke-ke, LIU He-sheng, QI Xiang-yang. Inhibitory effect of mogrosides crude extract on α-glucosidase in vitro[J]. Science and Technology of Food Industry, 2016, (24): 111-115. DOI: 10.13386/j.issn1002-0306.2016.24.013
[7]	WU Cheng-ying, WU Qi-nan, WANG Hong, FAN Xiu-he. In vitro inhibitory effects of polyphenol extracts from Euryale ferox seed coat on α-glucosidase and α-amylase activities[J]. Science and Technology of Food Industry, 2015, (16): 91-94. DOI: 10.13386/j.issn1002-0306.2015.16.010
[8]	QIN Jing-jing, LI Qi-ji, XUE Yan, MA Lin, YANG Xiao-sheng. Study on extraction methods and α-glucosidase inhibitory activity from the total triterpenes of Rosa roxbughii[J]. Science and Technology of Food Industry, 2014, (10): 186-189. DOI: 10.13386/j.issn1002-0306.2014.10.033
[9]	ZHU Yun-ping, YUAN Zuo-yun, LI Xiu-ting, XIAO Lin, LIU Wen-qing. Screening of the strain capable of producing α-glucosidase inhibitor and the optimization of solid fermentation[J]. Science and Technology of Food Industry, 2014, (03): 151-154. DOI: 10.13386/j.issn1002-0306.2014.03.025
[10]	Study on α-glucosidase inhibitory activity of extracts from six varieties of Cucurbita moschata Duch.[J]. Science and Technology of Food Industry, 2012, (21): 93-95. DOI: 10.13386/j.issn1002-0306.2012.21.075

Supplements (0)

Cited By

Cited by

Periodical cited type(10)

1.	李映涛，苟珈棋，李桥峰，李园园，秦苗，普春霞，张爱丽. 长叶轮钟草根腐病病原菌的分离鉴定及4种芳香中药植物挥发油对其病原菌的抑制作用. 微生物学报. 2025(01): 303-322 .
2.	孔方南，黎新荣，赵静，周之珞，周彩霞，颜桢灵，罗培四，卓福昌，黄丽君，韦优. 不同成熟度对红果参果实品质及香气成分的影响. 食品工业科技. 2024(01): 63-71 . 本站查看
3.	陆玲，顾怀珊，赵凯玲，侯玉波，李明兵，张万巧，高建莉，文和明，田迎春，赵昶灵. 云南省马关县红果参产业发展现状、存在问题及其对策. 果树资源学报. 2024(04): 98-102+113 .
4.	顾怀珊，钟正阳，杨迪，赵凯玲，张万巧，邓国军，黄兴粉，王献，赵强彪，陆玲，李仕江，赵昶灵，杨忠益. 云南马关县红果参果实花色苷的紫外-可见光谱和含量. 中国农学通报. 2024(25): 127-131 .
5.	刘晓海，茹月蓉，张雪春，周旭红，何霞红，王振兴. 103种药食两用植物化学成分分析及功能活性评价. 中国食品学报. 2024(08): 385-402 .
6.	张文玲，吴琼，陈星宇. 红果参在三峡库区的引种表现及栽培管理要点. 南方农业. 2024(17): 69-72 .
7.	王健，徐文芬，孙庆文，祝久洁，陈春伶，万晓霞，田蓓. 红果参果酱加工工艺研究. 农产品加工. 2023(01): 20-25+28 .
8.	黄春跃，杨子璇，田蓓，王嘉伟，靳建杰，吴蔓，胡晓. 轮钟草花色苷粗提物和精制物的抗氧化及α-葡萄糖苷酶抑制活性研究. 食品科技. 2023(02): 215-221 .
9.	关玉婷，陈瑞瑞，蔡如玉，范蓓，孙晶，张瑞，张紫阳，常世敏. 超声辅助提取茄皮酚工艺优化及其降血糖功效研究. 食品工业科技. 2022(24): 254-260 . 本站查看
10.	万晓霞，孙庆文，陈春伶，徐文芬，祝久洁，陈亮. 红果参矿质元素含量测定及膳食营养评价. 现代食品. 2022(23): 109-114 .