Network Pharmacology Study on the Antibacterial Activity of Caffeoylquinic Acids

ZHU Wenqing; LI Lingyu; ZHANG Li; ZUO Zhaohe; ZHENG Zhenjia; MA Yue

doi:10.13386/j.issn1002-0306.2021030017

Volume 42 Issue 13

Jun. 2021

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Science and Technology of Food Industry > 2021 > 42(13): 11-20. > DOI: 10.13386/j.issn1002-0306.2021030017

ZHU Wenqing, LI Lingyu, ZHANG Li, et al. Network Pharmacology Study on the Antibacterial Activity of Caffeoylquinic Acids [J]. Science and Technology of Food Industry, 2021, 42(13): 11−20. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021030017.

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Network Pharmacology Study on the Antibacterial Activity of Caffeoylquinic Acids

1.
Beijing Vegetable Research Center, Beijing Academy of Agriculture and Forestry Science, Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing, Key Laboratory of Vegetable Postharvest Processing, Ministry of Agriculture and Rural Affairs, Beijing 100097, China
2.
College of Food Science and Engineering, Shandong Agricultural University, Key Laboratory of Food Processing Technology and Quality Control in Shandong Province, Taian 271018, China
3.
Shandong Zhongping Pharmaceutical Co., Ltd., Linyi 273300, China
4.
Shandong Yidelai Biological Technology Co., Ltd., Taian 271000, China

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Received Date: March 01, 2021
Available Online: May 10, 2021

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Abstract

Abstract

Objective:To explore the antibacterial mechanism of caffeoylquinic acids based on network pharmacology. Methods: Through literature mining and database search, the corresponding targets of caffeoylquinic acids, antibacterial related targets, and the common targets of them were obtained. The common targets were used to construct a protein-protein interaction (PPI) network, and perform Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genome (KEGG) analysis. Results: Caffeoylquinic acids correspond to 483 targets, 805 antibacterial related targets, and 75 antibacterial targets of caffeoylquinic acids, and the key targets were TNF、AKT1、ALB、MMP9、EGFR and MAPK8. GO analysis and KEGG pathway enrichment analysis results showed that the antibacterial mechanism of caffeoylquinic acids mainly involves biological processes such as response to stimulus, metabolic processes, biological regulation, multicellular biological processes, cell communication, and work together through pathways such as extracellular matrix organization, collagen degradation, activation of matrix metalloproteinases and nerve growth factor signalling. The results of molecular docking verification between compounds and molecular targets were good, which verified the accuracy of the prediction of network construction. Conclusion: This study reveals that the antibacterial activity of caffeoylquinic acids has the characteristics of multiple targets and multiple pathways, which lays the foundation for further research on its molecular mechanism.
- caffeoylquinic acids,
- network pharmacology,
- antibacterial activity,
- mechanism of action

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