Abstract: In order to improve the symptoms of "Shanghuo" and the universality of ginseng, the animals randomly divided into control group, the 2 g/kg and 4 g/kg ginseng group and ginseng dandelion root compatibility group were given intragastric administration for 19 days, respectively. Body temperature, blood pressure and 5-hydroxytryptamine (5-HT), thyroid-stimulating hormone (TSH), corticosterone (CORT) and other indicators associated with "Shanghuo" were measured. The results showed that the body temperature and blood pressure of the 2 g/kg and 4 g/kg groups were lower than those of the ginseng group, and the effect of the 4 g/kg group was more significant. Compared with the control group, the content of 5-HT in ginseng group decreased, and the contents of TSH, 17-hydroxy corticosteroid (17-OHCS), CORT, tumor necrosis factor-α (TNF-α) were significantly increased. Compared with ginseng group, the contents of 5-HT in the combination group of 2 g/kg and 4 g/kg ginseng and dandelion root compatibility group were increased, and the contents of TSH, 17-OHCS, CORT, TNF-α were significantly decreased (P<0.05). The results indicated that compatibility of ginseng and dandelion root could improve the value of ginseng and dandelion root, and regulate the symptoms of "Shanghuo" caused by ginseng consumption.