Abstract: This paper summarized the sampling results of food safety supervision issued by Henan Provincial Administration for Market Regulation in 2021, and analyzed them from multiple dimensions such as food category, unqualified items, sampling areas, packaging type, time, etc, so as to find out food safety risks and provide a reference for the regulatory authorities. It was found that among a total of 73918 batches of inspected food samples, 1417 batches were unqualified, with an overall qualified rate of 98.08%. The inspected samples covered 32 food categories in total. The qualified rates of 10 categories, including roasted seeds and nuts, frozen drinks, catering food, edible agricultural products, convenience food and so on, were lower than the overall qualified rate of 98.08%. The main risk indicators were excessive residues of pesticides and veterinary drugs, microbial contamination, unqualified quality index and excessive use of food additives, accounting for 88.08% of the total number of unqualified items. The unqualified rate in the fourth quarter was significantly higher than that in the first three quarters. The unqualified rate of bulk foods was higher than that of prepackaged foods. In 2021, the overall situation of food safety in Henan Province was good, but there were still varying degrees of risks in some categories and indicators. It was suggested to strengthen the supervision of high-risk categories, indicators, as well as enterprises with frequent problems, and enhance source management.