Abstract: To develop functional seabuckthorn lyophilized effervescent tablets, in this study, the appearance, taste and disintegration time were taken as the inspection indicators, the best preparation process was determined through fuzzy mathematics combined with response surface optimization test, and the quality of the effervescent tablets was analyzed. The results showed that the optimum formula was as follows: The additive amount of seabuckthorn lyophilized powder was 40.00%, the acid base ratio of disintegrant was 1:1.28, the additive amount of disintegrant was 41.89%, and the amount of sodium carboxymethyl cellulose (CMC-Na) was 3%. Under the best process conditions, the effervescent tablets have smooth surface, good taste and unique aroma of seabuckthorn, reaching a comprehensive score of 79.80±1.20. The effervescent tablets contained 5.85 mg/g of vitamin C and 5.26 mg/g of flavonoids, and the scavenging rates of DPPH free radicals and hydroxyl free radicals were 56.8% and 54.9%, respectively. This study enhanced the added value of seabuckthorn, and provided a theoretical basis for the development of seabuckthorn functional products.