低血糖生成指数面条对糖尿病小鼠糖脂代谢的影响

余梦玲; 张三杉; 张巧; 何雨婕; 李贤; 雷激

doi:10.13386/j.issn1002-0306.2022020071

低血糖生成指数面条对糖尿病小鼠糖脂代谢的影响

doi: 10.13386/j.issn1002-0306.2022020071

西华大学食品与生物工程学院，四川成都 610000

基金项目: 四川省科技厅项目（2020YFH0157）。

详细信息

作者简介:
余梦玲（1998−），女，硕士研究生，研究方向：食品科学，E-mail：1745611272@qq.com

通讯作者:
雷激（1966−），女，博士，教授，研究方向：食品营养学，E-mail：121175698@qq.com

中图分类号: TS201.4
计量
- 文章访问数: 76
- HTML全文浏览量: 20
- PDF下载量: 24
- 被引次数: 0
出版历程
- 收稿日期: 2022-02-14
- 网络出版日期: 2022-10-21
- 刊出日期: 2022-11-23

Effects of Low Glycemic Index Noodles on Glucose/Lipid Metabolism in Diabetic Mice

School of Food and Bioengineering, Xihua University, Chengdu 610000, China

摘要

摘要: 目的：评价喂食低血糖生成指数（Glycemic Index，GI）面条对链脲佐菌素（Streptozotocin，STZ）诱导的糖尿病小鼠糖脂代谢的改善作用。方法：雄性昆明小鼠用STZ诱导建模成功后，干预组饲喂7周低GI面条，测定其糖脂代谢指标，并与饲喂普通面条的模型对照组比较。结果：与模型组糖尿病小鼠相比，干预组糖尿病小鼠的体重、血清胰岛素（Insulin，INS）、肝糖原水平显著升高（P<0.05），血清糖化蛋白（Glycated Serum Proteins，GSP）、空腹血糖和脏器指数显著下降（P<0.05），口服糖耐量、肝脏与胰腺组织的损伤显著改善（P<0.05），血脂水平有改善趋势。结论：低GI面条对糖尿病小鼠的高血糖症状和脂代谢紊乱有改善作用，可为低GI食品的开发应用提供一定的参考。
- 血糖生成指数 /
- 糖尿病 /
- 糖代谢 /
- 脂代谢 /
- 面条
Abstract: Objective: To evaluate the effect of low-glycemic index (GI) noodles on improving glucose and lipid metabolism in diabetic mice induced by streptozotocin (STZ). Methods: Diabetic male Kunming mice were induced by STZ, the intervention group was fed with low GI noodles for 7 weeks, the glucose and lipid metabolism index were measured, and compared with the model control group fed with normal noodles. Results: Compared with the diabetic mice in the model group, the body weight, serum insulin (INS) and liver glycogen levels increased significantly (P<0.05) in the intervention group. The glycated serum proteins (GSP), fasting glucose and organ index were decreased significantly (P<0.05). Oral glucose tolerance, liver and pancreatic tissue damage improved significantly (P<0.05), lipid levels showed a trend of improvement. Conclusion: Low GI noodles had an improvement effect on hyperglycemia symptoms and lipid metabolism disorders in diabetic mice, which could provide some reference for the development and application of low GI food.
- glycemic index /
- diabetes /
- sugar metabolism /
- lipid metabolism /
- noodles

HTML全文

图 1 低GI面条对小鼠体重的影响（n=10）

Figure 1. Effect of low GI noodles on the body weight of the mice (n=10)

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图 2 低GI面条对小鼠血糖水平的影响（n=10）

Figure 2. Effect of low GI noodles on blood sugar level in mice (n=10)

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图 3 不同处理组小鼠的肝脏、胰腺组织观察（n=10）

Figure 3. Liver and pancreas tissues were observed in mice from different treatment groups (n=10)

注：a、c、e分别为正常对照组、低GI面条干预组、模型对照组小鼠的肝脏形态观察（400×）；b、d、f分别为正常对照组、低GI面条干预组、模型对照组小鼠的胰腺形态观察（400×）。

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表 1 低GI面条对小鼠空腹血糖的影响（n=10）

Table 1. Effect of low GI noodles on fasting blood glucose in mice (n=10)

组别	正常对照组（mmol/L）	模型对照组（mmol/L）	低GI面条干预组（mmol/L）
0周	4.77±0.36^aA	13.99±0.92^bA	14.16±0.38^bD
1周	5.21±0.57^aA	14.54±0.21^bA	14.68±0.34^bD
2周	4.70±0.36^aA	14.55±0.41^bA	14.43±0.14^bD
3周	5.03±0.34^aA	17.78±0.49^cB	13.82±0.11^bC
4周	5.06±0.28^aA	20.37±1.36^cC	13.64±0.16^bC
5周	4.99±0.39^aA	20.61±0.18^cC	12.24±0.34^bB
6周	5.38±0.32^aA	21.31±0.12^cD	10.44±0.28^bA
7周	5.27±0.26^aA	22.26±0.23^cE	10.37±0.38^bA
注：不同大写（小写）字母表示同列（同行）数值之间差异显著（P<0.05）。

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表 2 低GI面条对小鼠血糖AUC的影响（n=10）

Table 2. Effect of low GI noodles on blood sugar AUC in mice (n=10)

组别	AUC
模型对照组	2378.55±85.82^c
低GI面条干预组	1815.15±61.79^b
正常对照组	949.95±36.29^a
注：同列不同小写字母表示差异显著（P<0.05），表3~表7同。

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表 3 低GI面条对糖尿病小鼠血清生化指标的影响（n=10）

Table 3. Effect of low GI noodles on serum biochemical indicators in diabetic mice (n=10)

组别	HDL-C浓度（mmol/L）	LDL-C浓度（mmol/L）	TC浓度（mmol/L）	TG浓度（mmol/L）
正常对照组	1.24±0.10^b	0.41±0.03^a	1.91±0.34^a	0.95±0.09^a
模型对照组	1.12±0.08^a	0.48±0.04^b	2.86 ±0.64^b	1.22±0.03^c
低GI面条干预组	1.15 ±0.09^ab	0.45±0.03^ab	2.62±0.43^b	1.09±0.05^b

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表 4 低GI面条对糖尿病小鼠血清糖化蛋白（GSP）的影响（n=10）

Table 4. Effect of low GI noodles on serum glycosylated protein (GSP) in diabetic mice (n=10)

组别	浓度（μmol/L）
正常对照组	107.74±7.08^a
模型对照组	129.18±3.42^c
低GI面条干预组	123.20±3.59^b

下载: 导出CSV

表 5 低GI面条对糖尿病小鼠胰岛素（INS）测定的影响（n=10）

Table 5. Effect of low GI noodles on insulin (INS) determination in diabetic mice (n=10)

组别	浓度（mIU/L）
正常对照组	34.08±2.32^c
模型对照组	26.09±2.35^a
低GI面条干预组	31.69±1.95^b

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表 6 低GI面条对小鼠肝糖原的影响（n=10）

Table 6. Effect of low GI noodles on liver glycogen in mice (n=10)

组别	肝糖原浓度（mg/g）
正常对照组	6.33±0.17^c
模型对照组	5.54±0.08^a
低GI面条干预组	5.96±0.11^b

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表 7 低GI面条对小鼠脏器指数的影响（n=10）

Table 7. Effects of low GI noodles on organ index in mice (n=10)

组别	心脏（%）	脾脏（%）	肾脏（%）
正常对照组	0.61±0.04^a	0.17±0.01^a	0.66±0.02^a
模型对照组	0.68±0.03^a	0.25±0.03^b	0.74±0.03^b
低GI面条干预组	0.66±0.05^a	0.19±0.02^a	0.72±0.03^ab

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