• Scopus
  • CA
  • DOAJ
  • FSTA
  • JST
  • 北大核心期刊
  • 中国科技核心期刊CSTPCD
  • 中国精品科技期刊
  • RCCSE中国核心学术期刊
  • 中国农业核心期刊
  • 中国生物医学文献服务系统SinoMed收录期刊
中国精品科技期刊2020

低血糖生成指数面条对糖尿病小鼠糖脂代谢的影响

余梦玲 张三杉 张巧 何雨婕 李贤 雷激

余梦玲,张三杉,张巧,等. 低血糖生成指数面条对糖尿病小鼠糖脂代谢的影响[J]. 食品工业科技,2022,43(23):353−359. doi:  10.13386/j.issn1002-0306.2022020071
引用本文: 余梦玲,张三杉,张巧,等. 低血糖生成指数面条对糖尿病小鼠糖脂代谢的影响[J]. 食品工业科技,2022,43(23):353−359. doi:  10.13386/j.issn1002-0306.2022020071
YU Mengling, ZHANG Sanshan, ZHANG Qiao, et al. Effects of Low Glycemic Index Noodles on Glucose/Lipid Metabolism in Diabetic Mice[J]. Science and Technology of Food Industry, 2022, 43(23): 353−359. (in Chinese with English abstract). doi:  10.13386/j.issn1002-0306.2022020071
Citation: YU Mengling, ZHANG Sanshan, ZHANG Qiao, et al. Effects of Low Glycemic Index Noodles on Glucose/Lipid Metabolism in Diabetic Mice[J]. Science and Technology of Food Industry, 2022, 43(23): 353−359. (in Chinese with English abstract). doi:  10.13386/j.issn1002-0306.2022020071

低血糖生成指数面条对糖尿病小鼠糖脂代谢的影响

doi: 10.13386/j.issn1002-0306.2022020071
基金项目: 四川省科技厅项目(2020YFH0157)。
详细信息
    作者简介:

    余梦玲(1998−),女,硕士研究生,研究方向:食品科学,E-mail:1745611272@qq.com

    通讯作者:

    雷激(1966−),女,博士,教授,研究方向:食品营养学,E-mail:121175698@qq.com

  • 中图分类号: TS201.4

Effects of Low Glycemic Index Noodles on Glucose/Lipid Metabolism in Diabetic Mice

  • 摘要: 目的:评价喂食低血糖生成指数(Glycemic Index,GI)面条对链脲佐菌素(Streptozotocin,STZ)诱导的糖尿病小鼠糖脂代谢的改善作用。方法:雄性昆明小鼠用STZ诱导建模成功后,干预组饲喂7周低GI面条,测定其糖脂代谢指标,并与饲喂普通面条的模型对照组比较。结果:与模型组糖尿病小鼠相比,干预组糖尿病小鼠的体重、血清胰岛素(Insulin,INS)、肝糖原水平显著升高(P<0.05),血清糖化蛋白(Glycated Serum Proteins,GSP)、空腹血糖和脏器指数显著下降(P<0.05),口服糖耐量、肝脏与胰腺组织的损伤显著改善(P<0.05),血脂水平有改善趋势。结论:低GI面条对糖尿病小鼠的高血糖症状和脂代谢紊乱有改善作用,可为低GI食品的开发应用提供一定的参考。
  • 图  1  低GI面条对小鼠体重的影响(n=10)

    Figure  1.  Effect of low GI noodles on the body weight of the mice (n=10)

    图  2  低GI面条对小鼠血糖水平的影响(n=10)

    Figure  2.  Effect of low GI noodles on blood sugar level in mice (n=10)

    图  3  不同处理组小鼠的肝脏、胰腺组织观察(n=10)

    Figure  3.  Liver and pancreas tissues were observed in mice from different treatment groups (n=10)

    注:a、c、e分别为正常对照组、低GI面条干预组、模型对照组小鼠的肝脏形态观察(400×);b、d、f分别为正常对照组、低GI面条干预组、模型对照组小鼠的胰腺形态观察(400×)。

    表  1  低GI面条对小鼠空腹血糖的影响(n=10)

    Table  1.   Effect of low GI noodles on fasting blood glucose in mice (n=10)

    组别正常对照组
    (mmol/L)
    模型对照组
    (mmol/L)
    低GI面条干预组
    (mmol/L)
    0周4.77±0.36aA13.99±0.92bA14.16±0.38bD
    1周5.21±0.57aA14.54±0.21bA14.68±0.34bD
    2周4.70±0.36aA14.55±0.41bA14.43±0.14bD
    3周5.03±0.34aA17.78±0.49cB13.82±0.11bC
    4周5.06±0.28aA20.37±1.36cC13.64±0.16bC
    5周4.99±0.39aA20.61±0.18cC12.24±0.34bB
    6周5.38±0.32aA21.31±0.12cD10.44±0.28bA
    7周5.27±0.26aA22.26±0.23cE10.37±0.38bA
    注:不同大写(小写)字母表示同列(同行)数值之间差异显著(P<0.05)。
    下载: 导出CSV

    表  2  低GI面条对小鼠血糖AUC的影响(n=10)

    Table  2.   Effect of low GI noodles on blood sugar AUC in mice (n=10)

    组别AUC
    模型对照组2378.55±85.82c
    低GI面条干预组1815.15±61.79b
    正常对照组949.95±36.29a
    注:同列不同小写字母表示差异显著(P<0.05),表3~表7同。
    下载: 导出CSV

    表  3  低GI面条对糖尿病小鼠血清生化指标的影响(n=10)

    Table  3.   Effect of low GI noodles on serum biochemical indicators in diabetic mice (n=10)

    组别HDL-C浓度
    (mmol/L)
    LDL-C浓度
    (mmol/L)
    TC浓度
    (mmol/L)
    TG浓度
    (mmol/L)
    正常对照组1.24±0.10b0.41±0.03a1.91±0.34a0.95±0.09a
    模型对照组1.12±0.08a0.48±0.04b2.86 ±0.64b1.22±0.03c
    低GI面条干预组1.15 ±0.09ab0.45±0.03ab2.62±0.43b1.09±0.05b
    下载: 导出CSV

    表  4  低GI面条对糖尿病小鼠血清糖化蛋白(GSP)的影响(n=10)

    Table  4.   Effect of low GI noodles on serum glycosylated protein (GSP) in diabetic mice (n=10)

    组别浓度(μmol/L)
    正常对照组107.74±7.08a
    模型对照组129.18±3.42c
    低GI面条干预组123.20±3.59b
    下载: 导出CSV

    表  5  低GI面条对糖尿病小鼠胰岛素(INS)测定的影响(n=10)

    Table  5.   Effect of low GI noodles on insulin (INS) determination in diabetic mice (n=10)

    组别浓度(mIU/L)
    正常对照组34.08±2.32c
    模型对照组26.09±2.35a
    低GI面条干预组31.69±1.95b
    下载: 导出CSV

    表  6  低GI面条对小鼠肝糖原的影响(n=10)

    Table  6.   Effect of low GI noodles on liver glycogen in mice (n=10)

    组别肝糖原浓度(mg/g)
    正常对照组6.33±0.17c
    模型对照组5.54±0.08a
    低GI面条干预组5.96±0.11b
    下载: 导出CSV

    表  7  低GI面条对小鼠脏器指数的影响(n=10)

    Table  7.   Effects of low GI noodles on organ index in mice (n=10)

    组别心脏(%)脾脏(%)肾脏(%)
    正常对照组0.61±0.04a0.17±0.01a0.66±0.02a
    模型对照组0.68±0.03a0.25±0.03b0.74±0.03b
    低GI面条干预组0.66±0.05a0.19±0.02a0.72±0.03ab
    下载: 导出CSV
  • [1] PUNTHAKEE Z, GOLDENBERG R, KATZ P. Definition, classification and diagnosis of diabetes, prediabetes and metabolic syndrome[J]. Canadian Journal of Diabetes,2018,42:S10−S15.
    [2] MELLO V D D, LAAKSONEN D E. Dietary fibers: Current trends and health benefits in the metabolic syndrome and type 2 diabetes[J]. Arquivos Brasileiros De Endocrinologia & Metabologia,2009,53(5):09−18.
    [3] RESHMI S K, SUDHA M L, SHASHIREKHA M N. Starch digestibility and predicted glycemic index in the bread fortified with pomelo (Citrus maxima) fruit segments[J]. Food Chemistry,2017,23:957−965.
    [4] 钟雪婷, 康建平, 华苗苗, 等. 基于血糖生成指数的最新应用研究进展[J]. 粮油食品科技,2020,28(2):66−72. [ZHONG X T, KANG J P, HUA M M, et al. Recent advances in research on applications based on glycemic index[J]. Grain, Oil and Food Technology,2020,28(2):66−72.
    [5] 杨小雪. 红小豆淀粉消化性及血糖生成指数的影响因素研究[D]. 北京: 中国农业科学院, 2020

    YANG X X. Study on the factors affecting the digestibility and glycemic index of red small bean starch[D]. Beijing: The Chinese Academy of Agricultural Sciences, 2020.
    [6] SALMERÓN J, MANSON J E, STAMPFER M J, et al. Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women[J]. JAMA,1997,277(6):472−477. doi:  10.1001/jama.1997.03540300040031
    [7] AROCHA G M, GOMEZ M, ROSELL C M. Impact of legume flours on quality and in vitro digestibility of starch and protein from gluten-free cakes[J]. Food and Bioprocess Technology,2012,5(8):3142−3150. doi:  10.1007/s11947-011-0642-3
    [8] RYU H-S, ZENG J. Determining the optimal recipe for long-grain jasmine rice with sea tangle laminaria japonica, and its effect on the glycemic index[J]. Fisheries and Aquatic Sciences,2014,17(1):47−57. doi:  10.5657/FAS.2014.0047
    [9] JUN Y, BAE I Y, LEE S, et al. Utilisation of preharvest dropped apple peels as a flour substitute for a lower glycaemic index and higher fibre cake[J]. International Journal of Food Sciences and Nutrition,2014,65(1):62−68. doi:  10.3109/09637486.2013.830083
    [10] 陈宇航, 于克学, 王敏, 等. 超细豆渣粉面包的研制及其血糖生成指数的测定[J]. 食品科技,2016(10):133−138. [CHEN Y H, YU K X, WANG M, et al. Development of super fine bean residue powder bread and its determination of glycemic index[J]. Food Technology,2016(10):133−138.
    [11] 张宗颖. 低血糖生成指数杂粮复合馒头的研制及临床效果观察[D]. 张家口: 河北北方学院, 2019

    ZHANG Z Y. Development and clinical effect of hypoglycemia index[D]. Zhangjiakou: Hebei Northern College, 2019.
    [12] 韩小存. 低血糖指数豆类品种的筛选及其在面制品中的应用[D]. 郑州: 河南工业大学, 2013

    HAN X C. Screening of hypoglycemic index bean varieties and their application in noodle products[D]. Zhengzhou: Henan University of Technology, 2013.
    [13] 王佳, 黄桂颖, 陈海光. 天然食品的降糖作用及其研究进展天然食品的降糖作用及其研究进展[J]. 仲恺农业工程学院学报,2017,30(2):58−63. [WANG J, HUANG G Y, CHEN H G. The hypoglycemic effect and research progress of natural foods and its research progress[J]. Journal of Zhongkai College of Agricultural Engineering,2017,30(2):58−63. doi:  10.3969/j.issn.1674-5663.2017.02.010
    [14] 胡玲, 张俊, 雷激. 紫甘蓝挂面制备的关键技术研究[J]. 食品科技,2019,44(11):185−191. [HU L, ZHANG J, LEI J. Research on the key techniques for the preparation of purple cabbage hanging noodles[J]. Food Technology,2019,44(11):185−191.
    [15] 高雅君. 低血糖指数馒头加工工艺及其功能特性研究[D]. 郑州: 河南工业大学, 2018

    GAO Y J. Study on the processing process and functional characteristics of low-glycaemic index steamed bread with hypoglycemic index[D]. Zhengzhou: Henan University of Technology, 2018.
    [16] 王波. 番石榴叶提取物辅助降血糖作用及其机制研究[D]. 成都: 四川大学, 2007

    WANG B. Guava leaf extract-assisted hypoglycemic effect and its mechanism study[D]. Chengdu: Sichuan University, 2007.
    [17] 秦川, 邓巍, 徐艳峰, 等. 实验动物比较组织学彩色图谱[M]. 科学出版社, 2017, 25(3): 1−249

    QIN C, DENG W, XU Y F, et al. Comparative histology color atlas of laboratory animals[M]. Science Press, 2017, 25(3): 1−249.
    [18] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版)[J]. 国际内分泌代谢杂志,2021,41(5):482−548. [Diabetes Branch of Chinese Medical Association. Chinese guidelines for the prevention and treatment of type 2 diabetes mellitus (2020 edition)[J]. International Journal of Endocrinology and Metabolism,2021,41(5):482−548. doi:  10.3760/cma.j.cn121383-20210825-08063
    [19] 李耀冬, 叶静, 肖美添. 复方海藻膳食纤维对糖尿病小鼠降血糖作用的研究[J]. 食品工业科技,2014,35(10):341−345. [LI Y D, YE J, XIAO M T. Study on the hypoglycemic effect of compound seaweed dietary fiber in diabetic mice[J]. Food Industry Technology,2014,35(10):341−345.
    [20] 曾山容, 邓小敏, 易倍吉, 等. 中医药治疗2型糖尿病血脂异常的研究进展[J]. 大众科技,2021,23(4):73−75. [ZENG S R, DENG X M, YI B J, et al. Research progress in TCM treatment of type 2 DM dyslipidemia[J]. Mass Technology,2021,23(4):73−75. doi:  10.3969/j.issn.1008-1151.2021.04.022
    [21] 邹亚兰, 张卫兵, 贺有元, 等. 大柴胡汤对2型糖尿病合并肥胖患者血糖及血脂水平的影响[J]. 现代医学与健康研究电子杂志,2021,5(9):18−20. [ZOU Y L, ZHANG W B, HE Y Y, et al. Effect of Dacpleurum Tang on blood glucose and lipid levels in patients with type 2 diabetes and obesity[J]. Electronic Journal of Modern Medicine and Health Research,2021,5(9):18−20.
    [22] 赵薇, 崔焕波. 糖化血清白蛋白检测在糖调节受损及新诊断糖尿病人群中的临床意义[J]. 中外医疗,2015,34(9):195−196. [ZHAO W, CUI H B. Clinical significance of glycated serum albumin detection in people with impaired glucose regulation and newly diagnosed diabetes mellitus[J]. Chinese and Foreign Medical Care,2015,34(9):195−196. doi:  10.3969/j.issn.1674-0742.2015.09.091
    [23] 张慧, 洪雁, 顾正彪, 等. 3种谷物全粉中淀粉的消化性及影响因素[J]. 食品与发酵工业,2012,38(11):26−31. [ZHANG H, HONG Y, GU Z B, et al. Digestive properties and influencing factors of starch in the whole flour of 3 grains[J]. Food and Fermentation Industry,2012,38(11):26−31.
    [24] 程林, 陈斌, 蔡宝昌. 山药及其麸炒品的多糖部位对小鼠免疫功能的影响[J]. 中药新药与临床药理,2006,17(2):86−89. [CHENG L, CHEN B, CAI B C. Effect of the polysaccharide site of Chinese yam and its bran fry on the immune function in mice[J]. New Drugs and Clinical Pharmacology of Traditional Chinese Medicine,2006,17(2):86−89. doi:  10.3321/j.issn:1003-9783.2006.02.002
    [25] ZHAO G, KAN J, LI Z, et al. Structural features andimmunological activity of a polysaccharide from Dioscorea opposita Thunb roots[J]. Carbohydrate Polymers,2005,61(2):125−131. doi:  10.1016/j.carbpol.2005.04.020
    [26] 张敏. 荞麦凉茶工艺研究及其对Ⅱ型糖尿病小鼠降血糖作用[D]. 杨凌: 西北农林科技大学, 2014

    ZHANG M. Study on buckwheat herbal tea technology and its hypoglycemic effect in type diabetic mice[D]. Yangling: Northwest A & F University, 2014.
    [27] 缪铭, 江波, 张涛. Kabuli和Desi品种鹰嘴豆淀粉结构及功能性质[J]. 吉林大学学报(工学版),2008(6):1495−1500. [MIU M, JIANG B, ZHANG T. Structural and functional properties of the Kabuli and Desi varieties of chickpea starch[J]. Journal of Jilin University (Engineering Edition),2008(6):1495−1500.
    [28] DAVISON K M, TEMPLE N J. Cereal fiber, fruitfiber, and type 2 diabetes: Explaining the paradox[J]. Journal of Diabetes and Its Complications,2018,32(2):240−245. doi:  10.1016/j.jdiacomp.2017.11.002
    [29] 彭晓蝶, 秦樱瑞, 黄先智, 等. 桑叶-苦瓜混合粉对糖尿病小鼠的降糖作用[J]. 现代食品科技,2017,33(4):31−37. [PENG X D, QIN Y R, HUANG X Z, et al. The hypoglycemic effect of mulberry leaf-bitter gourd mixed powder on diabetic mice[J]. Modern Food Technology,2017,33(4):31−37.
    [30] 夏晴, 王箴言, 王玉, 等. 桦褐孔菌多糖对糖尿病小鼠的干预作用及机制[J]. 中国食品学报,2021,21(3):71−78. [XIA Q, WANG Z Y, WANG Y, et al. Intervention and mechanism of Betcinola polysaccharides in diabetic mice[J]. Chinese Journal of Food Products,2021,21(3):71−78.
    [31] 张宇, 姜毓君, 党芳芳, 等. 副干酪乳杆菌TD062对Ⅱ型糖尿病小鼠的降糖作用[J]. 中国食品学报,2020,20(5):106−112. [ZHANG Y, JIANG Y J, DANG F F, et al. The hypoglycemic effect of L. paracasei TD062 in type diabetic mice[J]. Chinese Journal of Food Products,2020,20(5):106−112.
  • 加载中
图(3) / 表(7)
计量
  • 文章访问数:  33
  • HTML全文浏览量:  6
  • PDF下载量:  19
  • 被引次数: 0
出版历程
  • 收稿日期:  2022-02-14
  • 网络出版日期:  2022-10-21
  • 刊出日期:  2022-11-23

目录

    /

    返回文章
    返回

    重要通知

    1、快速见刊:客座主编专栏征稿-食源性功能物质挖掘及评价
           2、喜讯 :《食品工业科技》被DOAJ数据库收录!
           3喜报:《食品工业科技》世界期刊影响力稳居Q2区
           4、祝贺:《食品工业科技》中国期刊影响力稳居Q1第二名