Abstract: The purpose of this study was to explore the composition of muscle nutrients in different culture models of P. monodon, and to provide a theoretical basis for subsequent industrial finishing and select the appropriate model of P. monodon according to the needs. Farming in low-salt soil ponds (salinity: 8.3‰, referred to as low-salt soil pond group), low-salt intensive pond culture (salinity: 7.8‰, referred to as low-salt intensive pond group) and high-salt intensive pond (salinity: 23.4‰, referred to as high-salt group) ,the P. monodon under three culture modes were tested, and the nutritional differences of the muscles of P. monodon under different cultivation modes were analyzed and compared through the analysis and comparison of muscle nutrients. The results showed that in terms of conventional nutrients, the muscle water content of P. monodon in the high-salt group was significantly lower than that of the low-salt intensive pond group and the low-salt soil pond group (P<0.05), the crude protein content of the low-salt intensive pond group was significantly lower than that of the high-salt group and the low-salt soil pond group (P<0.05), the high-salt group had the highest crude fat, ash content, significantly different from the other two groups (P<0.05). In terms of amino acid composition, the muscles of P. monodon raised in the three breeding modes all contain 17 amino acids. The high-salt group of P. monodon muscle had the highest content of essential amino acids, delicious+sweet amino acid content, and total amino acids. In terms of the evaluation of essential amino acids, the total essential amino acids (2336.27 mg/g N) and essential amino acid index (76.15) of the muscle of P. monodon in the high-salt group were the highest, followed by the low-salt intensive pond group, and the low-salt soil pond group were the lowest. In terms of fatty acid composition, a total of 17 fatty acids were detected. Under the three culture modes, the content of C16:0 (palmitic acid) in the muscle of P. monodon was the highest, and the content of EPA+DHA was the highest in the high-salt group. The results showed that the muscle nutrients of P. monodon under the high-salt intensive pond culture model are complete, with high edible value.