Abstract: In this study, ginger peel polysaccharide were combined with zinc sulfate, and its preparation process was optimized by single factor and response surface experiments with the chelation rate as the index. The digestion and absorption of ginger peel polysaccharide-zinc complex and zinc sulfate were analyzed by in vitro simulation of gastrointestinal digestion. The results showed that the optimal process conditions for preparing ginger peel polysaccharide-zinc complex were: Reaction temperature 60 ℃, reaction time 125 min, pH8, and mass ratio of polysaccharide and zinc 24:1. The chelation rate reached 98.53%±0.31% under these conditions, and the content of zinc determined by inductively coupled plasma mass spectrometer was approximately 21.17±0.25 mg/g. In vitro simulated gastrointestinal digestion research showed that the dissolution rate of ginger peel polysaccharide-zinc complex in gastrointestinal fluid was relatively stable, and gastric juice had little effect on the dissolution rate of ginger peel polysaccharide-zinc complex, and the dissolution rate and dialysis rate of ginger peel polysaccharide-zinc complex in intestinal fluid were higher than that of zinc sulfate. In summary, the ginger peel polysaccharide-zinc complex had high stability and bioavailability and acted as a new zinc supplement.