Abstract: Polygonatum is a herbaceous plant of Polygonatum in Liliaceae., which has the functions of tonifying Qi, nourishing Yin, strengthening spleen, moistening lung and benefiting kidney. Polygonatum polysaccharide is one of the main components of Polygonatum and Polygonatum is rich in polysaccharides. Polygonatum polysaccharide is a kind of natural product resource used as medicine and food, in which complex structure and rich biological activity have become one of the hot spots in the development and research of food, medicine and other fields. In this paper, the extraction, purification, structure analysis and bioactivities of Polygonatum polysaccharides are reviewed. The research direction and application prospect of Polygonatum polysaccharides are prospected in order to provide theoretical reference for further development and utilization of Polygonatum polysaccharides.