Abstract: The hyperlipidemia mouse model was established by the induction of high-fat diet, and the difference of liver lipid metabolites in mice during the intervention of compound tea was investigated based on the widely targeted metabolome technology. Thirty mice were randomly divided into high-fat diet group (NK) and compound green tea high (DH) and low (DL) dose groups. These three groups were fed with high-fat diet and gavaged with purified water and different concentrations of compound green tea extract (840.0 and 210.0 mg/kg). After the 30 day experiment, the body weight and liver lipid metabolites of mice were analyzed. The results showed that the final body weight and weight gain of mice in the compound tea dose groups were significantly different from those in the high-fat model group (P<0.01). In addition, 110 metabolites were detected in the liver of each treatment group, among which 22 metabolites, including lysophosphatidylcholine 16:1, (±) 12 (13) epoxy-9z-octadecenoic acid, prostaglandin E2, (±) 17-hydroxy-5Z, 8Z, 11Z, 14Z eicosatetraenoic acid, lysophosphatidylserine 22:5, prostaglandin D2, lysophosphatidylethanolamine 14:0 were significantly different in the liver of model control group; with the increase of compound tea concentration, the contents of lysophosphatidylcholine 16:1 and 6-keto-prostaglandin F1α、Lysophosphatidylserine 22:5, prostaglandin D2 and lysophosphatidylethanolamine 14:0 were down regulated, (±) 17-hydroxy-5Z, 8Z, 11Z, 14Z eicosatetraenoic acid was up-regulated, and the dyslipidemia of hyperlipidemia mice was also improved. In conclusion, compound tea could significantly inhibit weight gain and reduce blood lipid in hyperlipidemic mice, and its mechanism might be related to promoting liver lipid metabolism, making the above 22 different metabolites change to normal state.