Abstract: Semen Ziziphi Spinosae was used as materials in this experiment. The extraction technology of flavonoids from Semen Ziziphi Spinosae, the optimum ratio of concentrated liquid of jujube and Semen Ziziphi Spinosae with other ingredients, and the sleeping effect of the product after boiling granulation were studied. With flavonoids content as the index, the extraction process of flavonoids from Semen Ziziphi Spinosae was studied by single factor experiment and response surface methodology. The optimal extraction process was obtained as follows : stir-frying temperature 140 ℃, stir-frying time 6 min and solid-liquid ratio 1:30. Under these conditions, the flavonoids content of Semen Ziziphi Spinosae was 6.69 mg/g. With sensory evaluation as index, the optimum formula of sleep-friendly instant jujube powder was obtained by single factor and orthogonal test: Maltodextrin 20%, jujube juice concentrate 10%, sugar 15%, milk powder 4%. The instant jujube powder was obtained by boiling granulation. The activity test showed that the instant jujube powder could prolong the sleep time of pentobarbital sodium-induced mice and shorten the sleep latency of subthreshold pentobarbital sodium-induced mice. It can be determined that jujube powder has a certain effect on improving sleep.