食品接触用再生PET制品中非有意/有意添加物迁移量的筛查及安全评估

董犇 黎梓城 郑建国 刘中勇 陈胜 李丹 林勤保 钟怀宁

董犇,黎梓城,郑建国,等. 食品接触用再生PET制品中非有意/有意添加物迁移量的筛查及安全评估[J]. 食品工业科技,2021,42(18):252−260. doi:  10.13386/j.issn1002-0306.2021010103
引用本文: 董犇,黎梓城,郑建国,等. 食品接触用再生PET制品中非有意/有意添加物迁移量的筛查及安全评估[J]. 食品工业科技,2021,42(18):252−260. doi:  10.13386/j.issn1002-0306.2021010103
DONG Ben, LI Zicheng, ZHENG Jianguo, et al. Identification and Safety Assessment of the Migration of Intentionally and Non-intentionally Added Substances in Food Contact Recycled PET Product[J]. Science and Technology of Food Industry, 2021, 42(18): 252−260. (in Chinese with English abstract). doi:  10.13386/j.issn1002-0306.2021010103
Citation: DONG Ben, LI Zicheng, ZHENG Jianguo, et al. Identification and Safety Assessment of the Migration of Intentionally and Non-intentionally Added Substances in Food Contact Recycled PET Product[J]. Science and Technology of Food Industry, 2021, 42(18): 252−260. (in Chinese with English abstract). doi:  10.13386/j.issn1002-0306.2021010103

食品接触用再生PET制品中非有意/有意添加物迁移量的筛查及安全评估

doi: 10.13386/j.issn1002-0306.2021010103
基金项目: 国家重点研发计划项目(2016YFF0203705);广州海关科研项目(2020GZCK-026,2021GZCK12)
详细信息
    作者简介:

    董犇(1984−),男,博士,研究方向:食品接触材料中高关注物的检测,E-mail:dongb@iqtcnet.cn

    通讯作者:

    钟怀宁(1972−),男,硕士,研究员,研究方向:食品接触材料检测及安全评估,E-mail:Marco_zhong@iqtcnet.cn

  • 中图分类号: TS206.4

Identification and Safety Assessment of the Migration of Intentionally and Non-intentionally Added Substances in Food Contact Recycled PET Product

  • 摘要: 为评估再生PET材料中非有意/有意添加物的迁移风险,采用液相四极杆飞行时间质谱、气相色谱串联质谱和顶空串联气相色谱法建立了再生PET制品中非有意/有意添加物筛查的方法,并对迁移实验所得食品模拟物进行检测。结果表明,共筛查出了6个化合物,其中油酸甲酯、棕榈酸甲酯、三甘醇辛酸癸酸酯和三乙二醇二异辛酸酯等4个化合物是有意添加物,亚油酸甲酯和1, 2-双-(4-羧基-苯甲酰基)-乙烷是非有意添加物。检出的化合物均未在GB 9685-2016食品安全国家标准中列出,是未被允许使用的化学物质。依据毒理学关注阈值法评估所检出的化合物均为Cramer Ⅰ类物质,结合膳食暴露条件评估它们的暴露量大大低于安全暴露阈值1.8 mg/人/d,对人体健康产生危害的可能性较低。
  • 图  1  亚油酸甲酯(a)、油酸甲酯(b)和棕榈酸甲酯(c)三个化合物的质谱图

    Figure  1.  Mass spectrogram of methyl linoleate (a), methyl oleate (b) and methyl hexadecanoate (c)

    图  2  杯子、方盒和圆盒样品的不挥发性化合物迁移量的TIC图(95%乙醇,40 ℃、10 d)

    Figure  2.  TIC chromatogram of non-volatile compound migration of cup (a), box (b) and round box (c) samples (95% ethanol, 40 ℃, 10 d)

    图  3  三乙二醇二异辛酸酯(a)、三甘醇辛酸癸酸酯(b)和1,2-双-(4-羧基-苯甲酰基)-乙烷(c)三个化合物的EIC图

    Figure  3.  EIC chromatogram of triethylene glycol bis (2-ethylhexanoate) (a), triethylene glycol caprate-caprylate (b) and 1,2-bis-(4-carboxy-benzoyloxy) -ethane (c)

    图  4  三乙二醇二异辛酸酯(a)、三甘醇辛酸癸酸酯(b)和1,2-双-(4-羧基-苯甲酰基)-乙烷(c)三个化合物的质谱图

    Figure  4.  Mass spectrogram of triethylene glycol bis (2-ethylhexanoate) (a), triethylene glycol caprate caprylate (b) and 1,2-bis-(4-carboxy-benzoyloxy)-ethane (c)

    表  1  迁移实验条件

    Table  1.   Migration test conditions

    样品名称食品模拟物温度(℃)时间
    杯子

    50%乙醇702 h
    50%乙醇4010 d
    95%乙醇4010 d
    方盒

    95%乙醇602 h
    50%乙醇4010 d
    95%乙醇4010 d
    圆盒

    95%乙醇602 h
    50%乙醇4010 d
    95%乙醇4010 d
    下载: 导出CSV

    表  2  样品中半挥发性化合物迁移量测试结果

    Table  2.   Migration results of semi-volatile substances in the samples

    样品名称迁移实验条件检出化合物CAS迁移量(mg/kg)鉴别
    杯子50%乙醇,70 ℃,2 h未检出
    50%乙醇,40 ℃,10 d未检出
    95%乙醇,40 ℃,10 d油酸甲酯
    亚油酸甲酯
    112-62-9
    112-63-0
    0.0131
    0.0162
    IAS
    NIAS
    方盒95%乙醇,60 ℃,2 h未检出
    50%乙醇,40 ℃,10 d未检出
    95%乙醇,40 ℃,10 d棕榈酸甲酯
    油酸甲酯
    亚油酸甲酯
    112-39-0
    112-62-9
    112-63-0
    0.0060
    0.0095
    0.0103
    IAS
    IAS
    NIAS
    圆盒95%乙醇,60 ℃,2 h未检出
    50%乙醇,40 ℃,10 d未检出
    95%乙醇,40 ℃,10 d油酸甲酯
    亚油酸甲酯
    112-62-9
    112-63-0
    0.0066
    0.0070
    IAS
    NIAS
    下载: 导出CSV

    表  3  样品中不挥发性化合物迁移量测试结果

    Table  3.   Migration results of non-volatile substances in the samples

    样品名称迁移实验条件检出化合物CAS迁移量(mg/kg)鉴别
    杯子50%乙醇,70 ℃,2 h未检出
    50%乙醇,40 ℃,10 d三乙二醇二异辛酸酯94-28-00.00361IAS
    95%乙醇,40 ℃,10 d

    三乙二醇二异辛酸酯94-28-00.00551IAS
    三甘醇辛酸癸酸酯7346-78-30.0745IAS
    1,2-双-(4-羧基-苯甲酰基)-乙烷2225-05-00.00236NIAS
    方盒95%乙醇,60 ℃,2 h未检出
    50%乙醇,40 ℃,10 d三乙二醇二异辛酸酯94-28-00.00250IAS
    95%乙醇,40 ℃,10 d

    三乙二醇二异辛酸酯94-28-00.00362IAS
    三甘醇辛酸癸酸酯7346-78-30.00905IAS
    1,2-双-(4-羧基-苯甲酰基)-乙烷2225-05-00.00456NIAS
    圆盒95%乙醇,60 ℃,2h未检出
    50%乙醇,40 ℃,10 d三乙二醇二异辛酸酯94-28-00.00197IAS
    95%乙醇,40 ℃,10 d三乙二醇二异辛酸酯94-28-00.00215IAS
    三甘醇辛酸癸酸酯7346-78-30.00473IAS
    1,2-双-(4-羧基-苯甲酰基)-乙烷2225-05-00.00357NIAS
    下载: 导出CSV

    表  4  TTC法对检出化合物的安全评估

    Table  4.   The safe assessment of the detected substances by the TTC method

    检出物质
    CAS No.
    迁移量(mg/kg)
    暴露量
    (mg/人/d)
    毒理学关注阈值方法评估
    Cramer分类安全暴露阈值
    (mg/人/d)
    评价
    油酸甲酯112-62-90.01310.0131I类≤1.8对人体健康产生危害的可能性较低
    亚油酸甲酯112-63-00.01620.0162I类≤1.8对人体健康产生危害的可能性较低
    棕榈酸甲酯112-39-00.00600.0060I类≤1.8对人体健康产生危害的可能性较低
    三甘醇辛酸癸酸酯7346-78-30.07450.0745I类≤1.8对人体健康产生危害的可能性较低
    三乙二醇二异辛酸酯94-28-00.005510.00551I类≤1.8对人体健康产生危害的可能性较低
    1,2-双-(4-羧基-苯甲酰基)-乙烷2225-05-00.004560.00456I类≤1.8对人体健康产生危害的可能性较低
    注:所有检出化合物的迁移实验条件均为95%乙醇,40 ℃,10 d。
    下载: 导出CSV
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  • 收稿日期:  2021-01-15
  • 网络出版日期:  2021-08-06
  • 刊出日期:  2021-09-14

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