Abstract: In order to evaluate the antihyperlipidemic and hepatoprotective effects of Cerasus humilis fermentation juice,a hyperlipidemia model of SD rats was established with high fat feed. After 7 days of adaptive feeding,thirty healthy male rats were randomly divided into three groups(each group 10 rats):Control group,high lipid model group and Cerasus humilis fermentation juice(CF)group(the concentration of fermentation juice was 40%,the gavage dose was 10 mL/kg bw). SD Rats were given by oral gavage,once a day,for 10 weeks. Blood samples were collected from the orbital venous plexus at the end of week 0,week 2,week 4,week 6,week 8 and week 10. The levels of total cholesterol(TC),triglyceride(TG),low-density lipoprotein-cholesterin(LDL-C)and high-density lipoprotein-cholesterin(HDL-C)in serum were measured by automatic biochemical analyzer. Frozen section of livers was stained with oil red O,to assess the accumulation of hepatic lipid droplets and calculate their area ratio. HE staining was performed to observe the histopathological changes of liver. The results showed that the blood lipids of rats fluctuated with the extension of the modeling time. Compared with the model group,the concentrations of TG in serum was reduced significantly by 57.20%(P<0.05)at the end of week 8. At the end of the experiment,compared with the model group,the TC concentration in serum of the CF group was reduced by 10.02%(P>0.05),and the LDL-C concentration in serum,which was similar to the control group,was significantly reduced by 35.48%(P<0.05). Besides,the organ index of liver and area ratio of lipid droplets of the CF group were significantly reduced by 20.92%(P<0.05)and 27.50%(P<0.05),respectively. The results of HE staining presented that the hepatocyte lipid vacuoles were evidently decreased. The experimental results comprehensively indicated that CF didn’t only have the effect of regulating dyslipidemia in hyperlipidemia SD rats,but also could significantly improve liver lesions due to lipid deposition.