Abstract: In order to study the effect of anthocyanin from the Chinese dwarf cherry ‘Nongda No 4’ on the protection of aging mouse,a mouse model of aging was established by subcutaneously injecting D-galactose in the neck and back,and the aging mice were gavaged with different doses(500,250,125 mg·(kg·d)^-1)of anthocyanins. The heart,liver,spleen,lung and kidney indexes and the contents of malondialdehyde(MDA)and the activities of total antioxidant capacity(T-AOC),catalase(CAT),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)in the heart,liver,spleen,kidney and serum of mice were assessed. The results showed that compared with the control group,the liver,spleen and kidney indexes of mice in the model group decreased significantly(P<0.05),T-AOC,SOD,GSH-Px,and CAT activities in the serum and organs decreased significantly(P<0.05),and MDA content increased significantly(P<0.05),indicating successful construction of aging mice model. Compared with the model group,the liver,spleen and kidney indexes and T-AOC,SOD,GSH-Px,and CAT activities in the serum and organ tissues were increased significantly(P<0.05)and MDA content was decreased significantly(P<0.05)of mice in the high dose. Therefore,anthocyanins from the Chinese dwarf cherry ‘Nongda No 4’ can effectively improve the antioxidant ability and protection ability in mice.