Abstract: With Astragalus membranaceus, Siraitia grosvenorii and pear as raw materials, a kind of anti-haze and lung-clearing drink was developed. Taking contents of astragaloside and sensory evaluation as the index, orthogonal design on the basis of single factor tests were adopted to optimize the preparation process.By establishing the haze mouse model, the efficacy of anti-haze Qingfei drink was evaluated by the pathological conditions of the lungs and the contents of IL-6, TNF-α in the lung tissues. The results showed that the optimize preparative parameters were 9% of Astragalus membranaceus, 2% of Siraitia grosvenorii, 50% of pear and 0.1% of xanthan gum, the contents of Astragaloside of beverage was 0.84 mg/mL and the sensory evaluation scores were 94.67 under optimum formulation conditions.The product was uniform and bright with combining pear flavor and medicine fragrance, sweet and sour, taste appropriate.The anti-haze Qingfei drink could significantly improve the pathological damage of lung tissue in haze mice. Compared with model group, the contents of IL-6 and TNF-α in the treatment group was significantly decreased (P<0.01), which would play a role by reducing the inflammatory response.