Abstract: The regulation of Shanxi aged vinegar and its concentrate on blood lipid and blood glucose in hyperlipidemia mice were studied in order to evaluate the feasibility of vinegar concentrate instead of Shanxi aged vinegar on health care function. The hyperlipidemia mice model was established by feeding 60 kcal% high fat diets and oral gavaged by high and low doses of Shanxi aged vinegar (4, 1 mL/(kg·bw·d)) and its concentrate (16 or 4 mL/(kg·bw·d)). Mouse weight, epididymal fat mass, serum total cholesterol, triglyceride and high density lipoprotein cholesterol were detected to evaluate the function of blood lipid-lowing. Meanwhile, oral glucose tolerance test was conducted to determine the regulation ability of blood glucose. Results revealed that both Shanxi aged vinegar and its concentrate reduced the body weight, epididymal fat mass and fatty coefficient of hyperlipidemia mice, improved serum total cholesterol, triglyceride and high density lipoprotein cholesterol as well, and the function of vinegar concentrate was better than Shanxi aged vinegar. In addition, vinegar concentrate significantly reduced the fasting blood glucose and 2 h postprandial blood glucose of hyperlipidemia mice, while Shanxi aged vinegar was out of expectation. All the results illustrated that vinegar concentrate had better effect than Shanxi aged vinegar on regulation of blood lipid and blood glucose in hyperlipidemia mice.