Abstract: This study aims to investigate the antioxidant and hypoglycemic potentials of sweet potato(Ipomoea batatas L.)leaves by comparing antioxidant activity and α-glucosidase inhibitory activity of sweet potato leaf extracts from 7 varieties. The content of total polyphenols and flavonoids in sweet potato leaves was measured. The antioxidant activity(DPPH· scavenging ability,ABTS⁺· scavenging ability,·OH scavenging and reducing ability)and α-glucosidase inhibitory activity were evaluated by in vitro experiments. The results showed that there were significant differences in the content of total polyphenols and flavonoids,antioxidant activity and α-glucosidase inhibitory activity among sweet potato leaf extracts from 7 varieties. The content of total polyphenols in sweet potato leaves ranged from 15.02 to 33.33 mg GAE/g DW,and the content of total flavonoids from 1.06 to 3.11 mg RE/g DW. The content of total polyphenols and flavonoids was the highest in sweet potato leaves of Xushu 18,Jishu 18 and Longshu 9,without statistical differences(P>0.05). Free radical scavenging ability(DPPH·,ABTS⁺·,·OH)was the highest in Longshu 9. The reducing ability was the highest in Jishu 18. Shangshu 19 presented the highest α-glucosidase inhibitory activity. The content of total polyphenols and flavonoids showed an extremely positive correlation with antioxidant activity(P<0.01),but no obvious correlation with α-glucosidase inhibitory activity(P>0.05). This study demonstrates that sweet potato leaves are a good source of potential antioxidants and α-glucosidasee inhibitors,providing a theoretical basis for sweet potato cultivation and the selection of sweet potato varieties.