Abstract: The protective effect of cod-skin collagen peptide combining juice drink(CJD)on UV Irradiation-induced skin photoaging was investigated. Male ICR mice were randomly divided into five groups:normal group(NC),model group(MC),low dose CJD treatment group(CJD-L),medium dose CJD treatment group(CJD-M)and high dose CJD treatment group(CJD-H). The protective effect of CJD on photoaging was evaluated by clinical signs,histological morphology,content of water and hydroxyproline of UV-irradiation mice skin. The activities of total superoxide dismutase(T-SOD),catalase(CAT),glutathione peroxidase(GSH-Px)and the level of malondialdehyde(MDA)in skin and serum were assessed to explore the pathway of protection of CJD on UV Irradiation-induced skin photoaging. Compared with the model group,the CJD-M and CJD-H groups significantly reduced water loss(p<0.05)and collagen breakdown of photoaging skin(p<0.01),significantly enhanced activity of T-SOD,CAT,GSH-Px and decreased levels of MDA in skin and serum(p<0.05). This study showed that collagen peptide drinks could protect skin against UV irradiation-induced photodamage,which could effectively prevent and delay photoaging.