Abstract: MCM-41(Mobil Composition of Matter No. 41)nanosilica mesoporous molecular sieves were prepared with cetyl trimethyl ammonium bromide(CTAB)and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)Mn~2900(P131345)as a dual template,and further using MCM-41 as a carrier with natural quercetin antioxidant,low density polyethylene(LDPE)as a substrate to prepare a food anti-oxidation active packaging films.The product had a specific surface area of 439.173 m²/g,a pore volume of 0.665 cm³ g^-1,and a pore size distribution of 2.4 and 4.0 nm. After the quercetin was adsorbed,the average clearance rates of DPPH free radical at 24 and 1200 h were 56.75% and 66.01%. The diffusion rate of quercetin in the food simulants in active films prepared by quercetin adsorbed on mesoporous molecular sieve was lower than that of active quercetin films,decreased from 2.127×10^-13 to 3.089×10^-14. It showed that the anti-oxidation activity of food packaging prepared by using mesoporous molecular sieve as carrier would has anti-oxidant effect and sustained release.