Abstract: The enrichment effect of resveratrol in wine based on fluidized bed and five macroporous adsorption resins by building a fluidized bed enrichment device was explored in this paper.The enrichment effect of HPD826, DA-201, AB-8, H103 and HPD600 macroporous adsorption resins was compared by static adsorption test.The optimum adsorption resin was screened and applied to the enrichment resveratrol of wine in fluidized bed.The results showed that the fluidized bed enrichment device could ensure the uniform flow of fluid. Macroporous resins could improve the enrichment efficiency of resveratrol in wine, and the enrichment effect of H103 resin was the best, which was 94.00%.The optimum conditions for the dynamic adsorption of H103 resin were as follows: the flow rate of the sample was 1.5 BV/h, and the p H of the wine was kept constant.The analytical conditions were the first washing, mass fraction of 80% ethanol solution was washed with 1.0 BV/h, the adsorption rate of resveratrol was 89.4% and the resolution rate was 93.6%. When the resin amount was 0.0120 g and the liquor flow rate was1.5 BV/h, the result of HPLC showed that flow rate of wine sample.