转基因线虫在阿尔茨海默症研究中的应用

Application of transgenic Caenorhabditis elegans in Alzheimer's disease

摘要: 由于秀丽线虫基因与人类基因的同源性高达40%,其神经元的功能和神经递质与人类的也高度类似,因而秀丽线虫成为研究神经性疾病机制的有效模型。本文就转基因秀丽线虫在阿尔茨海默病中的研究进展进行了阐述,总结了近年来天然提取物在阿尔茨海默症中的应用,并对以转基因线虫为模型进行研究的单体进行了阐述。

Abstract: Since the Caenorhabditis elegans genome displayes high homology( 40%) to human genome and its functions of neurons and neurotransmitters are also highly similar with those of humans,Caenorhabditis elegans have become an effective model of the neural mechanisms of disease.Researches of applications of transgenic Caenorhabditis elegans in Alzheimer 's disease were focused on and the applications of natural extracts in Alzheimer's disease in recent years were summarized.Also some monomers that were applied in transgenic Caenorhabditis elegans were summed up.