Abstract: Objective: The technology for ultrasonic- microwave synergistic extracting polyphenols from Canarium album was optimized,which can provide certain references for actual production. Methods: On the basis of single factor experiments,the optimum conditions for the extraction of polyphenol was obtained by response surface methodology.Results: The optimum conditions of extracting polyphenol from Canarium album were as follows:microwave power 550 W,microwave extraction time 4.4 min,ultrasonic power 330 W,ethanol concentration 62%.Under these conditions,the polyphenol yield was 6.33%,which was close to the model predictive value of 6.35%.Conclusion: the optimum process was simple and rapid,which had good yield.Furthermore,this study offered not only an accurate and effective reference standard for industrial applications,but also a good reference value for widely exploitation and utilization of Canarium album resource.