Abstract: To investigate the lipid- decreasing effect of ethanolic extracts from Allium Mongolicum regel ( AMR) in mice.The female Kunming mice were randomly divided into control group, model group and treatment group.AMR extracts were added to high fat diet at dose of 0.15 m L / g ( equivalent to 1.5 g fresh AMR) for treatment group.The experiment was lasted for 10 weeks and TC, TG, LDL- C, HDL- C in plasma were measured every 2 weeks.Atherosclerosis index ( AI) and lipid comprehensive index ( LCI) were calculated. Hyperlipidemia model was established in mice by the high fat diet. The level of TC, TG, LDL- C in plasma and the value of AI, LCI could be decreased significantly in the hyperlipidemia mice by AMR extracts from the eighth week. AMR extracts have an obvious effect on lowering blood lipid of hyperlipidemia mice and treating hyperlipidemia mice, preventing and reducing the incidence of atherosclerosis potentially.