Abstract: The physical model and the numerical model were built to acquire some information on gas flow field, temperature field, pressure field and particle trajectory by the computational fluid dynamics ( CFD) model and algorithm.The effects of inlet temperature and feed rate on the water content of spray drying persimmon, powder recovery and outlet temperature were analyzed. The results showed that the values obtained from numberical simulation were very close to that of the orthogonal experiment. The optimal technical parameters of spray drying persimmon powders were established to be inlet temperature of 388 K, air feed volume of 0.05 m3/ s and feed rate of 4.5 × 10- 3L / s by combination of CFD and orthogonal experiment. Under the optimal conditions, the powder recovery was 78.14%. The results suggested that CFD could be used to simulate the process of spray drying persimmon powder effectively.