Abstract: A method for simultaneous determination of Mn and nine toxic elements in Chinese spirits by inductively coupled plasma mass spectrometry( ICP- MS) was established. After acidifying in nitric acid and low concentration of hydrochloric acid,the elements including Be,Cr,Mn,Ni,As,Cd,Sn,Sb,Hg and Pb in Chinese spirits were measured by ICP-MS directly. The addition of low concentration of hydrochloric acid could improve the stability of elements,especially Hg and Sn,effectively. Octopole reaction system(ORS) was used to eliminate the interference of chlorine ion and other mass spectral interference. The matrix maching and the internal standard elements mixed solution(Li,Y,In and Bi) had compensated the difference of sample transfer efficiency and evaporation rate of solvent. Under the optimum condition,the method had good linear relation.The detection limit of the 10 elements was in the range of 0.13¹2.15 ng/L,the RSD was 0.75%³.48%,and the recovery of standard addition was 93.80% ¹10.00%. The method was simple and rapid with high precision and accuracy,and could be used in Chinese spirits quality control and safety estimations.