Abstract: The dynamic models for uridine 5'- monophosphate batch fermentation by Saccharomyces cerevisiae recombinant strain was studied. The kinetic models for dry cell weight,the content of uridine 5'- monophosphate and residual sugar were proposed with the Logistic equation,Leudeking- Piret equation and class Luedeking- Piret equation though the parameters estimation and nonlinear least- squares fitting method.The results showed that the experimental values and the fitted values fit well by analyze fitted curve,the fit of the linear over 98%.The models can reflect the batch fermentation of uridine 5'- monophosphate well.