Abstract: A rapid and accurate method was established based on chromatography /triple quadrupole mass spectrometry ( GC-QqQ-MS/MS) to simultaneously determine 16 kinds of phthalate plasticizers in wines.To- bemeasured wine samples were extracted with hexane and separated with an TG- 5MS analytical column ( 30m ×0.25mm ( internal diameter) × 0.25μm film thickness) . The QqQ mass spectrometer was operated in a multiplereaction monitoring mode.The qualitative analysis of the samples was carried out by comparing the retention-time and ion-pair with that of standard material, and the quantitative analysis was carried out by the abundance of the ion-pair with that of the standard material.Results indicated that the limits of detection for phathalates in the test samples were 0.4ng /g; the relative standard deviation was in the range of 1.74% ⁴.95%, and the recoveries were in the range of 84% ~ 118%. The present method could be applied for the routine analysis of the 16 kinds of phthalate plasticizers in wines.