Abstract: To study the effect of the protection of anthocyanin from Black Beauty potato (BBPA) by D-galactose induced subacute aging mice’s oxidative injury.Kunming mice were randomly divided into normal control, model, BBPA low dose treated (50mg/kg.bw) , medium dose treated (100mg/kg kw) and high-dose treated (200mg/kg·kw) 5 groups.Senile model were established by D-galactose hypodermic in jection for 30 day, the different doses of BBPA had been administered to three therapy groups.Normal control and aging model groups were administered with saline water.After 30 day, the mice body weight, the activities of SOD, total (TC) and total (TG) in the serum;then the activities of T-AOC, SOD, GSH and MDA content in liver and brain were measured respectively.Compared with normal control group, body weight, activity of SOD in the serum, activity of GSH-Px in liver and brain obviously reduced and TG increased (p<0.05) by D-galactose induced aging mice.BBPA treated groups significantly increased body weigh, the activities of SOD in the serum and GSH-Px in liver and T-AOC、SOD、GSH-Px in brain (p<0.05) , and significantly decreased MDA contents in liver and brain (p<0.05) .This data suggested that BBPA had good antioxidant effect.The targeted effects on brain was much more significant than those on serum and liver.