Abstract: Anemia is one of the world's public nutrition and health problems, which is valued by people increasingly in recent years.According to the principle of compatibility of the traditional Chinese medicine, skins of four red peanuts, red dates, fungus were used as the main raw material to develop the oral solution with the foundation of enrich the blood.The optimal formula was determined by response surface analysis:the extract of peanut red skins of 0.04%, the jujube juice concentrate of 49%, the fungus juice concentrate of 25%, sodium cyclamate of 0.15%, citric acid of 0.03%.And the final score of sensory was 92.3.The stability of oral solution were studied, the result showed that the thermal stability and light stability were all appropriate and the shelf life of enrich the blood oral solution of peanut red skins would be up to 2 years at room temperature.