Abstract: To explore the effect of corn and buckwheat complex on the regulation of lipid metabolism in hyperlipidemic rats, 60 rats were randomly divided into blank control group, hyperlipidemic model group, positive group, corn group, buckwheat group, and corn-buckwheat complex powder group. The intervention was carried out for 4 weeks. The rats and their organs were weighed. Lipid levels, liver injury levels and antioxidant levels were measured, and histologic examination of liver pathology was performed. The results showed that compared to model group, corn-buckwheat complex powder was able to lower the levels of TC (1.8 mmol/L), TG (1.38 mmol/L), LDL-C (0.62 mmol/L), and regress the levels of HDL-C (1.27 mmol/L) significantly (P<0.05). In addition, the ALT and AST activity in these groups had experienced varying degrees of reduction, with the corn-buckwheat complex powder group decreased significantly. Concurrently, the serum of the corn-buckwheat complex powder groups exhibited increased activities of the total SOD and GSH-Px, while the serum levels of MDA and CHE were decreased, a pattern that was also observed in the liver. The results of HE staining indicated that the liver hepatocytes in the corn, buckwheat, and corn-buckwheat complex powder groups were more evenly distributed and had less big vesicular lipid droplets. The corn-buckwheat complex powder group showed the greatest improvement. The research indicated that corn-buckwheat complex powder can significantly regulate the level of lipid metabolism in rats on a high blood lipid diet, and improve the antioxidant capacity of the liver and repair liver damage.