Research Progress of Sea Cucumber Polysaccharides on the Structure, Health Efficacy and Mechanism

DONG Xinyu; MI Rui; WANG Fuyi; LI Haiman; LI Ying; CHEN Biyi; ZHAO Qiancheng

doi:10.13386/j.issn1002-0306.2024070404

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DONG Xinyu, MI Rui, WANG Fuyi, et al. Research Progress of Sea Cucumber Polysaccharides on the Structure, Health Efficacy and Mechanism[J]. Science and Technology of Food Industry, 2025, 46(8): 1−10. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2024070404.

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Research Progress of Sea Cucumber Polysaccharides on the Structure, Health Efficacy and Mechanism

DONG Xinyu^1,,
MI Rui²,
WANG Fuyi¹,
LI Haiman¹,
LI Ying^{1, 3, 4},
CHEN Biyi^{1, 3, 4},
ZHAO Qiancheng^{1, 3, 4, ,}

1.
College of Food Science and Engineering, Dalian Ocean University, Dalian 116023, China
2.
Liaoning Ocean and Fisheries Science Research Institute, Dalian 116023, China
3.
Dalian Key Laboratory of Marine Bioactive Substances Development and High Value Utilization, Dalian 116023, China
4.
Liaoning Provincial Marine Healthy Food Engineering Research Centre, Dalian 116023, China

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Received Date: July 30, 2024
Available Online: February 19, 2025

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Abstract

Abstract

Sea cucumber polysaccharides (SCPs) are characterized by their unique structural configurations and broad-spectrum bioactivities, which are manifested through their regulatory functions or interactions with microbial communities upon entering the organism. This paper systematically reviews SCPs into two primary categories: glycosaminoglycans (GAGs) and sulfated fucoidans, with detailed comparisons of their molecular weights, chemical compositions, monosaccharide ratios and sulfate contents. The mechanisms underlying their therapeutic effects are elucidated, including anticoagulant activity through thrombin inhibition and fibrinolytic enhancement, as well as immunomodulatory effects via macrophage activation and tumor cell apoptosis induction. Furthermore, the prebiotic potential of SCPs in modulating gut microbiota and alleviating metabolic disorders such as obesity and diabetes is reviewed. The feasibility of SCPs as bioactive agents for addressing various health issues, including thrombosis, cancer, obesity, and diabetes is demonstrated. Future research directions emphasize the development of SCPs in pharmaceutical and functional food applications, providing a theoretical foundation for their functional utilization.
- sea cucumber polysaccharide,
- classification and structure,
- health efficacy,
- anticoagulant effect,
- immunomodulation,
- regulation of intestinal flora,
- mechanism

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References (77)

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