Regulation of Yeast Extract-Curcumin on Intestinal Flora in Mice with Acute Alcoholic Liver Injury

HUANG Xiaoying; YU Haili; ZHENG Mingshan; LIU Xiaowen; ZHANG Yan

doi:10.13386/j.issn1002-0306.2023100198

Volume 45 Issue 15

Jul. 2024

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Science and Technology of Food Industry > 2024 > 45(15): 25-33. > DOI: 10.13386/j.issn1002-0306.2023100198

HUANG Xiaoying, YU Haili, ZHENG Mingshan, et al. Regulation of Yeast Extract-Curcumin on Intestinal Flora in Mice with Acute Alcoholic Liver Injury[J]. Science and Technology of Food Industry, 2024, 45(15): 25−33. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023100198.

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Regulation of Yeast Extract-Curcumin on Intestinal Flora in Mice with Acute Alcoholic Liver Injury

HUANG Xiaoying^{1, 2,},
YU Haili^{1, 2},
ZHENG Mingshan^{1, 2},
LIU Xiaowen³,
ZHANG Yan^{1, 2, ,}

1.
National Key Laboratory of Agricultural Microbialogy, Yichang 443000, China
2.
The Hubei Provincial Key Laboratory of Yeast Function, Yichang 443000, China
3.
China Three Gorges University Medical College, Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Yichang 443002, China

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Received Date: October 24, 2023
Available Online: June 05, 2024

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Abstract

Abstract

Objective: This study aimed to investigate the protective effect and mechanism of yeast extract and curcumin-yeast extract on acute alcoholic liver injury in mice. Methods: The mouse model of acute alcoholic liver injury was established, and the mice were administered with yeast extract and curcumin-yeast extract. Changes in ALT, AST, T-GSH, GSH-Px, and MDA levels were observed in the serum and liver tissue, respectively. Pathological sections of liver tissue were examined to observe the damage. The intestinal flora of mice was analyzed. Results: Compared with the model group, both yeast extract and curcumin-yeast extract reduced the levels of ALT, AST, MDA, TC, and TG, increased the activities of GSH-Px and T-GSH, and alleviated fatty infiltration and inflammatory infiltration of hepatocytes. Curcumin-yeast extract effectively restored the abundance of Acinetobacter, Prevotella, and Ruminococcus, which had been altered by alcohol. The restorative effect was superior to that of the yeast extract group. Conclusion: Yeast extract and curcumin-yeast extract showed significant protective effects against acute alcoholic liver injury in mice. This mechanism may be associated with the regulation of oxidative stress, lipid metabolism, and intestinal flora.
- yeast extract,
- curcumin,
- acute alcoholic liver injury,
- intestinal flora

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