Protective Effect of Tartaty Buckwheat Extract Fermented with <i>Pleurotus eryngii</i> on Alcoholic Liver and Stomach Injury in Mice

MA Yuqi; WANG Mei; CAO Xiaonian; LI Qiang; WU Dingtao; DONG Ling; ZHANG Fengju; HU Yichen

doi:10.13386/j.issn1002-0306.2023060119

Volume 45 Issue 11

May 2024

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Science and Technology of Food Industry > 2024 > 45(11): 296-306. > DOI: 10.13386/j.issn1002-0306.2023060119

MA Yuqi, WANG Mei, CAO Xiaonian, et al. Protective Effect of Tartaty Buckwheat Extract Fermented with Pleurotus eryngii on Alcoholic Liver and Stomach Injury in Mice[J]. Science and Technology of Food Industry, 2024, 45(11): 296−306. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023060119.

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Protective Effect of Tartaty Buckwheat Extract Fermented with Pleurotus eryngii on Alcoholic Liver and Stomach Injury in Mice

1.
Key Laboratory of Coarse Cereal Processing of Ministry of Agriculture and Rural Affairs, Sichuan Engineering and Technology Research Center of Coarse Cereal Industrialization, College of Food and Biological Engineering, Chengdu University, Chengdu 610106, China
2.
Luzhou Laojiao Co., Ltd., National Engineering Research Center of Solid-state Brewing, Luzhou 646000, China
3.
Research Institute of Agricultural Products Processing, Sichuan Academy of Agricultural Sciences, Chengdu 610066, China

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Received Date: June 11, 2023
Available Online: April 07, 2024

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Abstract

Abstract

Objective: To investigate the antioxidant activity of fermented tartaty buckwheat extract of Pleurotus eryngii in vitro as well as its protective effect on alcohol-induced liver and gastric mucosa injury in vivo. Methods: The study involved determining the contents of functional components in fermented tartary buckwheat extract and observing its antioxidant capacity. Mice models of chronic alcoholic liver and gastric mucosa injury were established using Lieber-DeCarli liquid feed. The protective effects of fermented tartary buckwheat extract at low and high doses (1.5 g/kg B.W., 3.0 g/kg B.W.) were investigated for both liver and gastric mucosa injury. Results: The extract of fermented buckwheat with Pleurotus eryngii contained more antioxidant components, the contents of polyphenols, flavonoids and triterpenes were 11.40±0.32 mgGAE/g DW, 17.19±0.30 mg RE/g DW and 7.59±0.24 mg/g, respectively. The contents of rutin and quercetin were as follows: 13.55±0.05 and 0.665±0.01 mg/g. The iron reducing antioxidant capacity and DPPH and ABTS⁺ free radical scavenging efficiency of Tartary buckwheat extract were 16.66±0.65, 33.49±1.26 and 15.68±1.17 μmol Trolox/g DW, respectively. Compared with the model group, both high-dose and low-dose groups significantly reduced malondialdehyde (P<0.05), aspartate aminotransferase (P<0.01), alanine aminotransferase (P<0.01), lactate dehydrogenase (P<0.05), and interleukin-1β (P<0.05) levels and significantly increased levels of superoxide dismutase (P<0.01) and glutathione peroxidase (P<0.01), downregulated protein expression levels of reactive oxygen species (P<0.01), rat sarcoma (P<0.01), rapidly accelerated fibrosarcoma (P<0.01), extracellular signal-regulated kinases (P<0.05), and mitogen activated protein kinase kinase (P<0.05). Conclusion: Fermented tartaty buckwheat extract of Pleurotus eryngii has good antioxidant activity, and has obvious protective effect on chronic alcoholic liver and gastric mucosa injury in mice.

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