Research Progress of <i>γ</i>-Aminobutyric Acid (GABA)

ZHOU Junping; XU Yujuan; WEN Jing; WU Jijun; YU Yuanshan; LI Chuyuan; WENG Shaoquan; ZHAO Min

doi:10.13386/j.issn1002-0306.2023050004

Volume 45 Issue 5

Feb. 2024

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Science and Technology of Food Industry > 2024 > 45(5): 393-401. > DOI: 10.13386/j.issn1002-0306.2023050004

ZHOU Junping, XU Yujuan, WEN Jing, et al. Research Progress of γ-Aminobutyric Acid (GABA)[J]. Science and Technology of Food Industry, 2024, 45(5): 393−401. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023050004.

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Research Progress of γ-Aminobutyric Acid (GABA)

1.
Sericultural & Agri-Food Research Institute Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, China
2.
College of Food Science, South China Agricultural University, Guangzhou 510642, China
3.
Guangzhou Wanglaoji Lychee Industry Development Company Co., Ltd., Guangzhou 510623, China

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Received Date: May 03, 2023
Available Online: December 27, 2023

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Abstract

Abstract

γ-aminobutyric acid (GABA) is a non-protein amino acid discovered in animals, plants, and microorganisms that was approved as the "new resource food" by the National Health Commission of the People's Republic of China (NHC) in 2009. It has a wide range of applications in food, medicine, feed, and other industries, and the research has grown increasingly popular in recent years. The paper reviews the bio-synthesis and metabolic processes of GABA, summarizes the methods of chemical synthesis, plant enrichment, and present GABA detection techniques, and discusses their advantages and limitations. Furthermore, the main physiological functions and mechanism of GABA are summarized, and GABA’s research and development trend is also presented, in order to provide reference for future research and application of GABA.
- γ-aminobutyric acid,
- metabolic pathways,
- enrichment,
- detection method,
- bioactivity

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References (85)

References

[1]	OKETCH-RABAH H A, MADDEN E F, ROE A L, et al. United States Pharmacopeia (USP) safety review of gamma-aminobutyric acid (GABA)[J]. Nutrients,2021,13(8):2742. doi: 10.3390/nu13082742
[2]	RAMESH S A, TYERMAN S D, GILLIHAM M. γ-aminobutyric acid (GABA) signalling in plants[J]. Cellular and Molecular Life Sciences:CMLS,2017,74(9):1577−1603. doi: 10.1007/s00018-016-2415-7
[3]	YANG W, LEI Z, HU Y. Investigations of the thermal properties, nucleation kinetics, and growth of γ-aminobutyric acid in aqueous ethanol solution[J]. Industrial & Engineering Chemistry Research,2010,49(22):11170−11175.
[4]	BOWN A W, SHELP B J. Does the GABA shunt regulate cytosolic GABA?[J]. Trends in Plant Science,2020,25(5):422−424. doi: 10.1016/j.tplants.2020.03.001
[5]	MICHAELI S, FAIT A, LAGOR K, et al. A mitochondrial GABA permease connects the GABA shunt and the TCA cycle, and is essential for normal carbon metabolism[J]. The Plant Journal,2011,67(3):485−498. doi: 10.1111/j.1365-313X.2011.04612.x
[6]	KATEŘINA P, LYDIA U, LUKÁŠ S, et al. Phytohormones and polyamines regulate plant stress responses by altering GABA pathway[J]. New Biotechnology,2018,48:53−65.
[7]	YANG R, GUO Q, GU Z. GABA shunt and polyamine degradation pathway on γ-aminobutyric acid accumulation in germinating fava bean (Vicia faba L.) under hypoxia[J]. Food Chemistry, 2013, 136(1):152−159.
[8]	CHE-OTHMAN M H, JACOBY R P, MILLAR A H, et al. Wheat mitochondrial respiration shifts from the tricarboxylic acid cycle to the GABA shunt under salt stress.[J]. The New Phytologist,2020,225(3):1166−1180. doi: 10.1111/nph.15713
[9]	STUDART-GUIMARÃES C, FAIT A, NUNES-NESI A, et al. Reduced expression of succinyl-coenzyme a ligase can be compensated for by up-regulation of the γ-aminobutyrate shunt in illuminated tomato leaves[J]. Plant Physiology,2007,145(3):626−639. doi: 10.1104/pp.107.103101
[10]	SALMINEN A, JOUHTEN P, SARAJÄRVI T, et al. Hypoxia and GABA shunt activation in the pathogenesis of alzheimer's disease[J]. Neurochemistry International,2016,92:13−24. doi: 10.1016/j.neuint.2015.11.005
[11]	SHELP B J, BOZZO G G, TROBACHER C P, et al. Hypothesis/review:Contribution of putrescine to 4-aminobutyrate (GABA) production in response to abiotic stress[J]. Plant Science,2012,193:130−135.
[12]	周沫霖. 低温和二氧化碳胁迫下龙眼γ-氨基丁酸富集与机理研究[D]. 广州:华南农业大学, 2017. [ZHOU M L. Study on γ-aminobutyric acid (GABA) accumulation and regulation mechanism in longan (Dimocarpus longan Lour.) fruit in response to cold stress and CO₂ stress[D]. Guangzhou:South China Agricultural University, 2017.] ZHOU M L. Study on γ-aminobutyric acid （GABA） accumulation and regulation mechanism in longan （Dimocarpus longan Lour.） fruit in response to cold stress and CO₂ stress[D]. Guangzhou: South China Agricultural University, 2017.
[13]	CARON P C, KREMZNER L T, COTE L J. GABA and its relationship to putrescine metabolism in the rat brain and pancreas[J]. Neurochemistry International,1987,10(2):219−229. doi: 10.1016/0197-0186(87)90131-8
[14]	SEQUERRA E B, GARDINO P, HEDIN-PEREIRA C, et al. Putrescine as an important source of GABA in the postnatal rat subventricular zone[J]. Neuroscience,2007,146(2):489−493. doi: 10.1016/j.neuroscience.2007.01.062
[15]	杨东元, 陈开勋, 王亚红. γ-氨基丁酸的合成研究[J]. 中国饲料,2010(1):27−28. [YANG D Y, CHEN K X, WANG Y H. Study on synthesis of γ-aminobutanoic acid[J]. China Feed,2010(1):27−28.] YANG D Y, CHEN K X, WANG Y H. Study on synthesis of γ-aminobutanoic acid[J]. China Feed, 2010（1）: 27−28.
[16]	王金玲, 袁军, 刘登才. γ-氨基丁酸的合成[J]. 化学与生物工程,2010,27(3):40−41. [WANG J L, YUAN J, LIU D C. Synthesis of γ-aminobutyric acid[J]. Chemistry & Bioengineering,2010,27(3):40−41.] WANG J L, YUAN J, LIU D C. Synthesis of γ-aminobutyric acid[J]. Chemistry & Bioengineering, 2010, 27（3）: 40−41.
[17]	董学君. 一种氨酪酸的制造方法:CN200710010078.1[P]. 2010-05-19. [DONG X J. A synthetic method of Aminobutyric acid:CN200710010078.1[P]. 2010-05-19.] DONG X J. A synthetic method of Aminobutyric acid: CN200710010078.1[P]. 2010-05-19.
[18]	PABLO G C, JOSEFINA M V, GRACIELA S D G, et al. Enhancement of γ-aminobutyric acid (GABA) production by Lactobacillus brevis crl 2013 based on carbohydrate fermentation[J]. International Journal of Food Microbiology,2020,333:108792. doi: 10.1016/j.ijfoodmicro.2020.108792
[19]	张恕铭, 曾林, 孙向阳, 等. 屎肠球菌与植物乳杆菌共培养产 γ-氨基丁酸条件优化及关键酶活性研究[J]. 食品与发酵工业,2021,47(9):154−159. [ZHANG S M, ZENG L, SUN X Y, et al. Optimization of γ-aminobutyric acid produced by co-culturing Enterococcus faecium and Lactobacillus plantarum and the activities of key enzyme[J]. Food and Fermentation Industries,2021,47(9):154−159.] ZHANG S M, ZENG L, SUN X Y, et al. Optimization of γ-aminobutyric acid produced by co-culturing Enterococcus faecium and Lactobacillus plantarum and the activities of key enzyme[J]. Food and Fermentation Industries, 2021, 47（9）: 154−159.
[20]	张敏. γ-氨基丁酸乳酸菌诱变选育及其发酵条件优化[D]. 芜湖:安徽工程大学, 2020. [ZHANG M. Mutagenesis breeding of enterococcus faecalis producing GABA and optimization of fermentation conditions[D]. Wuhu:Anhui Polytechnic University, 2020.] ZHANG M. Mutagenesis breeding of enterococcus faecalis producing GABA and optimization of fermentation conditions[D]. Wuhu: Anhui Polytechnic University, 2020.
[21]	黄俊. 利用短乳杆菌制备γ-氨基丁酸相关过程研究[D]. 杭州:浙江大学, 2006. [HUANG J. Process study on the preparation of γ-aminobutyric acid by Lactobacillus brevis[D]. Hangzhou:Zhejiang University, 2006.] HUANG J. Process study on the preparation of γ-aminobutyric acid by Lactobacillus brevis[D]. Hangzhou: Zhejiang University, 2006.
[22]	NORIKO K, JUN S, SHINICHI K, et al. Production of γ-aminobutyric acid (GABA) by Lactobacillus paracasei isolated from traditional fermented foods[J]. Food Microbiology,2005,22(6):497−504. doi: 10.1016/j.fm.2005.01.002
[23]	LIN Q. Submerged fermentation of Lactobacillus rhamnosus ys9 for γ-aminobutyric acid (GABA) production[J]. Brazilian Journal of Microbiology,2013,44(1):183−187. doi: 10.1590/S1517-83822013000100028
[24]	LEE B, KIM J, KANG Y M, et al. Antioxidant activity and γ-aminobutyric acid (GABA) content in sea tangle fermented by Lactobacillus brevis bj20 isolated from traditional fermented foods[J]. Food Chemistry,2010,122(1):271−276. doi: 10.1016/j.foodchem.2010.02.071
[25]	LE H P, PARMENTIER N, LE T T, et al. Evaluation of using a combination of enzymatic hydrolysis and lactic acid fermentation for γ-aminobutyric acid production from soymilk[J]. LWT,2021,142:111044. doi: 10.1016/j.lwt.2021.111044
[26]	WAN A A Q I, MOHAMAD N A S, MOHAMAD F I, et al. Isolation, identification, and optimization of γ-aminobutyric acid (GABA)-producing Bacillus cereus strain kbc from a commercial soy sauce moromi in submerged-liquid fermentation[J]. Processes,2020,8(6):652. doi: 10.3390/pr8060652
[27]	YOGESWARA I B A, KITTIBUNCHAKUL S, RAHAYU E S, et al. Microbial production and enzymatic biosynthesis of γ-aminobutyric acid (GABA) using Lactobacillus plantarum fncc 260 isolated from indonesian fermented foods[J]. Processes,2020,9(1):22. doi: 10.3390/pr9010022
[28]	AB KADIR S, WAN-MOHTAR W A A Q, MOHAMMAD R, et al. Evaluation of commercial soy sauce koji strains of Aspergillus oryzae for γ-aminobutyric acid (GABA) production[J]. Journal of Industrial Microbiology and Biotechnology,2016,43(10):1387−1395. doi: 10.1007/s10295-016-1828-5
[29]	HASEGAWA M, YAMANE D, FUNATO K, et al. Gamma-aminobutyric acid fermentation with date residue by a lactic acid bacterium, Lactobacillus brevis[J]. Journal of Bioscience and Bioengineering,2018,125(3):316−319. doi: 10.1016/j.jbiosc.2017.10.003
[30]	PU Y, SINCLAIR A J, ZHONG J, et al. Determination of γ-aminobutyric acid (GABA) in jujube fruit (Ziziphus jujuba mill.)[J]. CyTA-Journal of Food, 2019, 17(1):158-162.
[31]	LI R, LI Z J, WU N N, et al. The effect of cold plasma pretreatment on GABA, γ-oryzanol, phytic acid, phenolics, and antioxidant capacity in brown rice during germination[J]. Cereal Chemistry,2023,2(100):321−332.
[32]	TU J, LIU G, JIN Y, et al. Enrichment of γ-aminobutyric acid in mulberry leaves and the inhibitory effects of the water extract on ace and α-glucosidase activity[J]. Industrial Crops and Products,2022,177:114485. doi: 10.1016/j.indcrop.2021.114485
[33]	杨苞梅, 姚丽贤, 李国良, 等. 不同品种荔枝果肉游离氨基酸及香气组分分析[J]. 热带作物学报,2014,35(6):1228−1234. [YANG B M, YAO L X, LI G L, et al. Analysis of amino acids and aromatic components of pulps for different litchi variety[J]. Chinese Journal of Tropical Crops,2014,35(6):1228−1234.] YANG B M, YAO L X, LI G L, et al. Analysis of amino acids and aromatic components of pulps for different litchi variety[J]. Chinese Journal of Tropical Crops, 2014, 35（6）: 1228−1234.
[34]	陈卓慧, 胡卓炎, 吕恩利, 等. 不同贮藏方式对双肩玉荷包荔枝氨基酸变化的影响[J]. 现代食品科技,2013,29(8):1955−1960. [CHEN Z H, HU Z Y, LÜ E L, et al. Changes in amino acid contents of Shuangjianyuhebao litchi during different storage conditions[J]. Modern Food Science and Technology,2013,29(8):1955−1960.] CHEN Z H, HU Z Y, LÜ E L, et al. Changes in amino acid contents of Shuangjianyuhebao litchi during different storage conditions[J]. Modern Food Science and Technology, 2013, 29（8）: 1955−1960.
[35]	白青云, 高红侠, 陈佳雯, 等. 超声辅助盐胁迫对荸荠中 γ-氨基丁酸富集的影响[J]. 食品科技,2021,46(8):76−81. [BAI Q Y, GAO H X, CHEN J W, et al. Effects of ultrasonic assisted salt stress on γ-aminobutyric acid accumulation in water chestnut[J]. Food Science and Technology,2021,46(8):76−81.] BAI Q Y, GAO H X, CHEN J W, et al. Effects of ultrasonic assisted salt stress on γ-aminobutyric acid accumulation in water chestnut[J]. Food Science and Technology, 2021, 46（8）: 76−81.
[36]	YOUN Y, PARK J, JANG H, et al. Sequential hydration with anaerobic and heat treatment increases GABA ( γ-aminobutyric acid) content in wheat[J]. Food Chemistry,2011,129(4):1631−1635. doi: 10.1016/j.foodchem.2011.06.020
[37]	周新勇, 陆燕婷, 尹永祺, 等. 低氧联合酸胁迫富集大麦芽中γ-氨基丁酸工艺优化[J]. 中国粮油学报,2020,35(6):144−150. [ZHOU X Y, LU Y T, YIN Y Q, et al. Optimization of hypoxia combined with acid stress processing conditionsfor enriching γ-aminobutyric acid (GABA) in malt[J]. Journal of the Chinese Cereals and Oils Association,2020,35(6):144−150.] ZHOU X Y, LU Y T, YIN Y Q, et al. Optimization of hypoxia combined with acid stress processing conditionsfor enriching γ-aminobutyric acid （GABA） in malt[J]. Journal of the Chinese Cereals and Oils Association, 2020, 35（6）: 144−150.
[38]	黄柳舒, 沈莲清, 王向阳. 改良比色法测桑叶中 γ-氨基丁酸含量及其热稳定性研究[J]. 食品科技,2010,35(8):328−331. [HUANG L S, SHEN L Q, WANG X Y. Spectrophotometry improvement determination of γ-aminobutyric acid inmulberry leaf and study on its thermal stability[J]. Food Science and Technology,2010,35(8):328−331.] HUANG L S, SHEN L Q, WANG X Y. Spectrophotometry improvement determination of γ-aminobutyric acid inmulberry leaf and study on its thermal stability[J]. Food Science and Technology, 2010, 35（8）: 328−331.
[39]	陈恩成, 张名位, 彭超英, 等. 比色法快速测定糙米中 γ-氨基丁酸含量研究[J]. 中国粮油学报,2006(1):125−128. [CHEN E C, ZHANG M W, PENG C Y, et al. Spectrophometric determination of γ-aminobutyric acid in brown rice[J]. Journal of the Chinese Cereals and Oils Association,2006(1):125−128.] CHEN E C, ZHANG M W, PENG C Y, et al. Spectrophometric determination of γ-aminobutyric acid in brown rice[J]. Journal of the Chinese Cereals and Oils Association, 2006（1）: 125−128.
[40]	万蓝婷, 李暄妍, 程建峰, 等. Berthelot比色法测定植物叶片中 γ-氨基丁酸(GABA)含量的体系优化[J]. 植物生理学报,2021,57(7):1462−1472. [WAN L T, LI X Y, CHENG J F, et al. Systematic optimization of Berthelot colorimetry for determining γ-aminobutyric acid (GABA) content in plant leaves[J]. Plant Physiology Journal,2021,57(7):1462−1472.] WAN L T, LI X Y, CHENG J F, et al. Systematic optimization of Berthelot colorimetry for determining γ-aminobutyric acid （GABA） content in plant leaves[J]. Plant Physiology Journal, 2021, 57（7）: 1462−1472.
[41]	JINNARAK A, TEERASONG S. A novel colorimetric method for detection of gamma-aminobutyric acid based on silver nanoparticles[J]. Sensors and Actuators B: Chemical,2016,229:315−320. doi: 10.1016/j.snb.2016.01.115
[42]	王能凤. 红枣γ-氨基丁酸测定方法的优化及应用研究[D]. 阿拉尔:塔里木大学, 2022. [WANG N F. Research on optimization and application of determination method of γ-aminobutyric acid in jujube[D]. Alaer:Tarim University, 2022.] WANG N F. Research on optimization and application of determination method of γ-aminobutyric acid in jujube[D]. Alaer: Tarim University, 2022.
[43]	王能凤, 杨家荣, 蒲云峰, 等. 红枣中 γ-氨基丁酸的功能及检测方法的研究进展[J]. 农产品加工,2022(14):94−96. [WANG N F, YANG J R, PU Y F, et al. Research progress of function and detection methods of γ-aminobutyric acid in jujube fruit[J]. Farm Products Processing,2022(14):94−96.] WANG N F, YANG J R, PU Y F, et al. Research progress of function and detection methods of γ-aminobutyric acid in jujube fruit[J]. Farm Products Processing, 2022（14）: 94−96.
[44]	刘红梅, 魏淘涛, 刘行丹, 等. 发芽糙米 γ-氨基丁酸的检测及研究进展[J]. 作物研究,2012,26(1):88−92. [LIU H M, WEI T T, LIU X D, et al. Determination methods and research progress of gamma aminobutyric acid in germinated brown rice[J]. Crop Research,2012,26(1):88−92.] LIU H M, WEI T T, LIU X D, et al. Determination methods and research progress of gamma aminobutyric acid in germinated brown rice[J]. Crop Research, 2012, 26（1）: 88−92.
[45]	李雁琴. 红枣中GABA检测方法优化及其变化规律的研究[D]. 阿拉尔:塔里木大学, 2020. [LI Y Q. Study on the optimization of γ-aminobutyric acid detection method andits variation rule in jujube[D]. Alaer:Tarim University, 2020.] LI Y Q. Study on the optimization of γ-aminobutyric acid detection method andits variation rule in jujube[D]. Alaer: Tarim University, 2020.
[46]	郭旭光, 尹玉云, 徐晓楠. 高效液相-柱后衍生-荧光检测法测定保健品中 γ-氨基丁酸的含量[J]. 河南预防医学杂志,2020,31(12):894−896. [GUO X G, YIN Y Y, XU X N. HPLC determination of gamma-aminobutyric acid in health care productswith post-column derivatization and fluorescence detection[J]. Henan Journal of Preventive Medicine,2020,31(12):894−896.] GUO X G, YIN Y Y, XU X N. HPLC determination of gamma-aminobutyric acid in health care productswith post-column derivatization and fluorescence detection[J]. Henan Journal of Preventive Medicine, 2020, 31（12）: 894−896.
[47]	王丽群, 潘媛媛, 孟庆虹, 等. 基于柱后衍生发芽糙米中 γ-氨基丁酸HPLC检测方法的建立及应用[J]. 中国酿造,2016,35(2):144−147. [WANG L Q, PAN Y Y, MENG Q H, et al. Establishment and application of the HPLC determination method for γ-aminobutyric acid in germinated brown rice based on postcolumn derivation[J]. China Brewing,2016,35(2):144−147.] WANG L Q, PAN Y Y, MENG Q H, et al. Establishment and application of the HPLC determination method for γ-aminobutyric acid in germinated brown rice based on postcolumn derivation[J]. China Brewing, 2016, 35（2）: 144−147.
[48]	邢志强. 茶叶γ-氨基丁酸富集方法及其检测方法的研究[D]. 合肥:安徽农业大学, 2009. [XING Z Q. Study of enriching ways and analytical method on the γ-aminobutyric acid in tea leaves[D]. Hefei:Anhui Agricultural University, 2009.] XING Z Q. Study of enriching ways and analytical method on the γ-aminobutyric acid in tea leaves[D]. Hefei: Anhui Agricultural University, 2009.
[49]	杜金凤, 郭航宏, 陶晓杰, 等. DABS-Cl柱前衍生HPLC测定发芽糙米粉中 γ-氨基丁酸[J]. 食品工业,2021,42(6):468−472. [DU J F, GUO H G, TAO X J, et al. Determine of γ-aminobuytric acid in germinated brown rice powder by HPLC with DABS-Cl precolumn derivatization[J]. The Food Industry,2021,42(6):468−472.] DU J F, GUO H G, TAO X J, et al. Determine of γ-aminobuytric acid in germinated brown rice powder by HPLC with DABS-Cl precolumn derivatization[J]. The Food Industry, 2021, 42（6）: 468−472.
[50]	杨晶晶, 刘英, 崔秀明, 等. 高效液相色谱法测定三七地上部分 γ-氨基丁酸的含量[J]. 中国中药杂志,2014,39(4):606−609. [YANG J J, LIU Y, CUI X M, et al. Determination of γ-aminobutyric acid in aerial part of panax notoginseng by HPLC[J]. China Journal of Chinese Materia Medica,2014,39(4):606−609.] YANG J J, LIU Y, CUI X M, et al. Determination of γ-aminobutyric acid in aerial part of panax notoginseng by HPLC[J]. China Journal of Chinese Materia Medica, 2014, 39（4）: 606−609.
[51]	刘宗乐, 高林森, 张东东, 等. 高效液相色谱法测定乳酸菌发酵液中 γ-氨基丁酸[J]. 中国酿造,2022,41(11):233−238. [LIU Z L, GAO L S, ZHANG D D, et al. Determination of γ-aminobutyric acid in lactic acid bacteria fermentationbroth by HPLC[J]. China Brewing,2022,41(11):233−238.] LIU Z L, GAO L S, ZHANG D D, et al. Determination of γ-aminobutyric acid in lactic acid bacteria fermentationbroth by HPLC[J]. China Brewing, 2022, 41（11）: 233−238.
[52]	胡雪莲, 王宏华, 王莉娜. 高效液相色谱法测定黑莓果汁及黑莓啤酒中的 γ-氨基丁酸[J]. 中国酿造,2015,34(3):150−153. [HU X L, WANG H H, WANG L N. Determination of γ-aminobutyric acid in blackberry juice and blackberry beer by HPLC[J]. China Brewing,2015,34(3):150−153.] HU X L, WANG H H, WANG L N. Determination of γ-aminobutyric acid in blackberry juice and blackberry beer by HPLC[J]. China Brewing, 2015, 34（3）: 150−153.
[53]	DAI D, QIN Q, ZHU X, et al. A high performance liquid chromatography tandem mass spectrometry protocol for detection of neurotransmitters in the rat brain tissue[J]. MethodsX,2023,10:102083. doi: 10.1016/j.mex.2023.102083
[54]	BERGH M S, BOGEN I L, LUNDANES E, et al. Validated methods for determination of neurotransmitters and metabolites in rodent brain tissue and extracellular fluid by reversed phase UHPLC-MS/MS[J]. Journal of Chromatography B,2016,1028:120−129. doi: 10.1016/j.jchromb.2016.06.011
[55]	秦宇, 侯蓓蓓, 张斌骏, 等. 超高效液相色谱-串联质谱法测定南瓜中 γ-氨基丁酸的含量[J]. 食品安全质量检测学报,2020,11(2):528−532. [QIN Y, HOU B B, ZHANG B J, et al. Simultaneous determination of γ-aminobutyric acid in pumpkin by ultraperformance liquid chromatography-tandem mass spectrometry[J]. Journal of Food Safety & Quality,2020,11(2):528−532.] QIN Y, HOU B B, ZHANG B J, et al. Simultaneous determination of γ-aminobutyric acid in pumpkin by ultraperformance liquid chromatography-tandem mass spectrometry[J]. Journal of Food Safety & Quality, 2020, 11（2）: 528−532.
[56]	ZHAO M, TUO H, WANG S, et al. The effects of dietary nutrition on sleep and sleep disorders[J]. Mediators of Inflammation,2020(25):3142874.
[57]	BRUNI O, FERINI-STRAMBI L, GIACOMONI E, et al. Herbal remedies and their possible effect on the GABAergic system and sleep[J]. Nutrients,2021,13(2):530. doi: 10.3390/nu13020530
[58]	GOTTESMANN C. GABA mechanisms and sleep[J]. Neuroscience,2002,111(2):231−239. doi: 10.1016/S0306-4522(02)00034-9
[59]	YAMATSU A, YAMASHITA Y, PANDHARIPANDE T, et al. Effect of oral γ-aminobutyric acid (GABA) administration on sleep and its absorption in humans[J]. Food Science and Biotechnology,2016,25(2):547−551. doi: 10.1007/s10068-016-0076-9
[60]	HEPSOMALI P, GROEGER J A, NISHIHIRA J, et al. Effects of oral gamma-aminobutyric acid (GABA) administration on stress and sleep in humans:A systematic review[J]. Frontiers in Neuroscience,2020,14:923. doi: 10.3389/fnins.2020.00923
[61]	JEONG A, HWANG J, JO K, et al. Fermented gamma aminobutyric acid improves sleep behaviors in fruit flies and rodent models[J]. International Journal of Molecular Sciences,2021,22(7):3537. doi: 10.3390/ijms22073537
[62]	李科, 俞兰秀, 刘小雨, 等. γ-氨基丁酸改善睡眠作用机制的研究进展[J]. 食品工业科技,2019,40(14):353−358. [LI K, YU L X, LIU X Y, et al. Research progress on improving sleep mechanism of γ-aminobutyric acid[J]. Science and Technology of Food Industry,2019,40(14):353−358.] LI K, YU L X, LIU X Y, et al. Research progress on improving sleep mechanism of γ-aminobutyric acid[J]. Science and Technology of Food Industry, 2019, 40（14）: 353−358.
[63]	WANG H, WANG Z, CHEN N. The receptor hypothesis and the pathogenesis of depression:Genetic bases and biological correlates[J]. Pharmacological Research,2021,167:105542. doi: 10.1016/j.phrs.2021.105542
[64]	FARAJDOKHT F, VOSOUGHI A, ZIAEE M, et al. The role of hippocampal GABA a receptors on anxiolytic effects of echium amoenum extract in a mice model of restraint stress[J]. Molecular Biology Reports,2020,47(9):6487−6496. doi: 10.1007/s11033-020-05699-7
[65]	TAFET G E, NEMEROFF C B. Pharmacological treatment of anxiety disorders:The role of the hpa axis[J]. Frontiers in Psychiatry,2020,11:443. doi: 10.3389/fpsyt.2020.00443
[66]	CAI L, TAO Q, LI W, et al. The anti-anxiety/depression effect of a combined complex of casein hydrolysate and γ-aminobutyric acid on C57BL/6 mice[J]. Frontiers in Nutrition,2022,9:971853. doi: 10.3389/fnut.2022.971853
[67]	SANACORA G, MASON G F, ROTHMAN D L, et al. Increased cortical GABA concentrations in depressed patients receiving ect[J]. American Journal of Psychiatry,2003,160(3):577−579. doi: 10.1176/appi.ajp.160.3.577
[68]	陈青峰, 贺婧, 谢小梅, 等. 淡豆豉炮制中 γ-氨基丁酸含量测定及其抗抑郁作用研究[J]. 药物评价研究,2021,44(4):688−694. [CHEN Q F, HE J, XIE X M, et al. Determination of content of γ-aminobutyric acid and its antidepressant effect at different time points during processing of sojae semen praeparatum[J]. Drug Evaluation Research,2021,44(4):688−694.] CHEN Q F, HE J, XIE X M, et al. Determination of content of γ-aminobutyric acid and its antidepressant effect at different time points during processing of sojae semen praeparatum[J]. Drug Evaluation Research, 2021, 44（4）: 688−694.
[69]	AL-KURAISHY H M, HUSSIAN N R, AL-NAIMI M S, et al. The potential role of pancreatic γ-aminobutyric acid (GABA) in diabetes mellitus:A critical reappraisal[J]. International Journal of Preventive Medicine,2021,12(1):19.
[70]	HOSSEINI DASTGERDI A, SHARIFI M, SOLTANI N. GABA administration improves liver function and insulin resistance in offspring of type 2 diabetic rats[J]. Scientific Reports,2021,11(1):23155. doi: 10.1038/s41598-021-02324-w
[71]	PRUD'HOMME G J, GLINKA Y, KURT M, et al. The anti-aging protein klotho is induced by GABA therapy and exerts protective and stimulatory effects on pancreatic beta cells[J]. Biochemical and Biophysical Research Communications,2017,493(4):1542−1547. doi: 10.1016/j.bbrc.2017.10.029
[72]	LIN E E, SCOTT-SOLOMON E, KURUVILLA R. Peripheral innervation in the regulation of glucose homeostasis[J]. Trends in Neurosciences,2021,44(3):189−202. doi: 10.1016/j.tins.2020.10.015
[73]	LIU Y, WENG W, WANG S, et al. Effect of γ-aminobutyric acid-chitosan nanoparticles on glucose homeostasis in mice[J]. ACS Omega,2018,3(3):2492−2497. doi: 10.1021/acsomega.7b01988
[74]	DUPONT A G, LÉGAT L. GABA is a mediator of brain at 1 and at 2 receptor-mediated blood pressure responses[J]. Hypertension Research,2020,43(10):995−1005. doi: 10.1038/s41440-020-0470-9
[75]	LÉGAT L, SMOLDERS I, DUPONT A G. At 1 receptor mediated hypertensive response to ang ii in the nucleus tractus solitarii of normotensive rats involves no dependent local GABA release[J]. Frontiers in Pharmacology,2019,10:460. doi: 10.3389/fphar.2019.00460
[76]	MILANEZ M I, SILVA A M, PERRY J C, et al. Pattern of sympathetic vasomotor activity induced by GABAergic inhibition in the brain and spinal cord[J]. Pharmacological Reports,2020,72:67−79. doi: 10.1007/s43440-019-00025-w
[77]	KIMURA M, HAYAKAWA K, SANSAWA H. Involvement of γ-aminobutyric acid (GABA) b receptors in the hypotensive effect of systemically administered GABA in spontaneously hypertensive rats[J]. Japanese Journal of Pharmacology,2002,89(4):388−394. doi: 10.1254/jjp.89.388
[78]	AKAMA K, KANETOU J, SHIMOSAKI S, et al. Seed-specific expression of truncated osgad 2 produces GABA-enriched rice grains that influence a decrease in blood pressure in spontaneously hypertensive rats[J]. Transgenic Research,2009,18:865−876. doi: 10.1007/s11248-009-9272-1
[79]	HUSSIN F S, CHAY S Y, ZAREI M, et al. Potentiality of self-cloned Lactobacillus plantarum taj-apis362 for enhancing GABA production in yogurt under glucose induction:optimization and its cardiovascular effect on spontaneous hypertensive rats[J]. Foods,2020,9(12):1826. doi: 10.3390/foods9121826
[80]	XU Y, ZHAO M, HAN Y, et al. GABAergic inhibitory interneuron deficits in alzheimer's disease:Implications for treatment[J]. Frontiers in Neuroscience,2020,14:660. doi: 10.3389/fnins.2020.00660
[81]	ZHANG Z, JING Y, MA Y, et al. Driving GABAergic neurons optogenetically improves learning, reduces amyloid load and enhances autophagy in a mouse model of alzheimer's disease[J]. Biochemical and Biophysical Research Communications,2020,525(4):928−935. doi: 10.1016/j.bbrc.2020.03.004
[82]	INOTSUKA R, UDONO M, YAMATSU A, et al. Exosome-mediated activation of neuronal cells triggered by γ-aminobutyric acid (GABA)[J]. Nutrients,2021,13(8):2544. doi: 10.3390/nu13082544
[83]	YANG J, CHEN J, LIU Y, et al. Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA[J]. Neuron,2023,111(7):1104−1117. doi: 10.1016/j.neuron.2022.12.033
[84]	HUANG D, WANG Y, THOMPSON J W, et al. Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression[J]. Nature cell Biology,2022,24(2):230−241. doi: 10.1038/s41556-021-00820-9
[85]	HUANG D, ALEXANDER P B, LI Q, et al. GABAergic signaling beyond synapses:An emerging target for cancer therapy[J]. Trends in Cell Biology, 2022. doi: 10.1016/j.tcb.2022.08.004.

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