Research Progress in the Detoxification Technology of Mycotoxins

MA Shuai; LI An; PAN Ligang

doi:10.13386/j.issn1002-0306.2023030323

Volume 45 Issue 5

Feb. 2024

Turn off MathJax

Article Contents

Abstract

References

Supplements

Science and Technology of Food Industry > 2024 > 45(5): 377-383. > DOI: 10.13386/j.issn1002-0306.2023030323

MA Shuai, LI An, PAN Ligang. Research Progress in the Detoxification Technology of Mycotoxins[J]. Science and Technology of Food Industry, 2024, 45(5): 377−383. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023030323.

Citation:

PDF (971 KB)

Research Progress in the Detoxification Technology of Mycotoxins

Institute of Quality Standard and Testing Technology of Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China

More Information

Received Date: March 28, 2023
Available Online: December 27, 2023

Graphical Abstract

Abstract

Abstract

Mycotoxins can be defined as toxic secondary metabolites that are formed and released by many fungal species, which widely exist in agricultural products and their by-products, resulting thus in a serious threat to human and animal health. In recent years, the removal of mycotoxins has been extensively investigated in the literature. This work mainly focuses on the research progress of the pollution characteristics, limit standards and removal technologies of mycotoxins. The research progress of fungus physical adsorption detoxification technology based on graphene, metal organic framework and magnetic nanomaterial adsorbent is systematically summarized, especially. The development of new types of functional nanomaterials with enhanced properties is undoubted of great importance for mycotoxin prevention applications by using physical adsorption technology.
- mycotoxin,
- detoxification technology,
- physical adsorption,
- new functional nanomaterials

FullText(HTML)

References (49)

References

[1]	MARIN S, RAMOS A J, CANO-SANCHO G, et al. Mycotoxins:Occurrence, toxicology, and exposure assessment[J]. Food and Chemical Toxicology,2013,60:218−237. doi: 10.1016/j.fct.2013.07.047
[2]	ZHAO L, ZHANG L, XU Z J, et al. Occurrence of aflatoxin b₁, deoxynivalenol and zearalenone in feeds in China during 2018-2020[J]. Journal of Animal Science and Biotechnology,2021,12:74. doi: 10.1186/s40104-021-00603-0
[3]	范楷, 祭芳, 韩铮, 等. 长三角地区市场常见农产品中40种真菌毒素的污染状况和特征分析[J]. 中国农业科学,2021,54(13):2870−2884. [FAN K, JI F, HAN Z, et al. Natural occurrence and characteristic analysis of 40 mycotoxins in agro-products from Yangtze Delta Region[J]. Scientia Agricultura Sinica,2021,54(13):2870−2884.] doi: 10.3864/j.issn.0578-1752.2021.13.015 FAN K, JI F, HAN Z, et al. Natural occurrence and characteristic analysis of 40 mycotoxins in agro-products from Yangtze Delta Region[J]. Scientia Agricultura Sinica, 2021, 54（13）: 2870−2884. doi: 10.3864/j.issn.0578-1752.2021.13.015
[4]	翟晨, 穆蕾, 杨悠悠. 中国及欧盟粮油食品真菌毒素限量及减控措施对比[J]. 现代食品科技,2020,36(3):302−308. [ZHAI C, MU L, YANG Y Y. Comparison of mycotoxins limit standards and control measures of grain and oil foods between China and European Union:A review[J]. Modern Food Science and Technology,2020,36(3):302−308.] ZHAI C, MU L, YANG Y Y. Comparison of mycotoxins limit standards and control measures of grain and oil foods between China and European Union: A review[J]. Modern Food Science and Technology, 2020, 36（3）: 302−308.
[5]	SELVARAJA N J, WAN Y, ZHOU L, et al. A review of recent mycotoxin survey data and advanced mycotoxin detection techniques reported from China[J]. Food Additives & Contaminants: Part A,2015,32:440−452.
[6]	DUBRAVKA R, DANIELA J, ANDREA H T, et al. Sterigmatocystin moderately induces oxidative stress in male wistar rats after short-term oral treatment[J]. Mycotoxin Research,2020,36(2):181−191. doi: 10.1007/s12550-019-00382-8
[7]	国家食品药品监督管理总局. GB 2761-2017食品安全国家标准食品中真菌毒素限量[S]. 北京:中国标准出版社, 2017. [China Food and Drug Administration. GB 2761-2017 National food safety standard Mycotoxin limit in food[S]. Beijing:China Standards Press, 2017.] China Food and Drug Administration. GB 2761-2017 National food safety standard Mycotoxin limit in food[S]. Beijing: China Standards Press, 2017.
[8]	Codex Alimentarius Commission. Codex general standard for contaminants and toxins in food and feed:Codex Stan 193-2017[S]. Rome:Official Journal of the Codex Alimentarius Commission, 2017:9−38.
[9]	The Commission of The European Communities, Regulation (EC) No 1881/2006 of 19 December 2006 Setting Maximum Levels for Certain Contaminants in Foodstuffs:(EC) No 1881 /2006[S
[10]	SELVARAJ J N, WANG Y, ZHOU L, et al. Recent mycotoxin survey data and advanced mycotoxin detection techniques reported from China:A review[J]. Food Additives and Contaminants Part A,2015,32:440−452. doi: 10.1080/19440049.2015.1010185
[11]	HOVE M, VAN P C, NJUMBE-EDIAGE E, et al. Review on the natural co-occurrence of AFB₁ and FB₁ in maize and the combined toxicity of AFB₁ and FB₁[J]. Food Control,2016,59:675−682. doi: 10.1016/j.foodcont.2015.06.053
[12]	ADEBO O A, KAYITESI E, NJOBEH P B. Reduction of mycotoxins during fermentation of whole grain sorghum to whole grain Ting (a Southern African Food)[J]. Toxins,2019,11:180. doi: 10.3390/toxins11030180
[13]	阴佳璐. 浑浊红球菌PD630对黄曲霉毒素B₁生物降解的研[D]. 广州:华南理工大学, 2020:26−28. [YIN J L. Study on biodegradation of aflatoxin B₁ by Rhodococcus opacus pd630[D]. Guangzhou:South China University of Technology, 2020:26−28.] YIN J L. Study on biodegradation of aflatoxin B₁ by Rhodococcus opacus pd630[D]. Guangzhou: South China University of Technology, 2020: 26−28.
[14]	ALBERTS J F, GELDERBLOM W C A, BOTHA A, et al. Degradation of aflatoxin b₁ by fungal laccase enzymes[J]. International Journal of Food Microbiology,2009,135:47−52. doi: 10.1016/j.ijfoodmicro.2009.07.022
[15]	ZHANG Z, LI M, WU C, et al. Physical adsorption of patulin by saccharomyces cerevisiae during fermentation[J]. Journal of Food Science and Technology,2019,56:2326−2331. doi: 10.1007/s13197-019-03681-1
[16]	YOUNG J C, ZHOU T, YU H, et al. Degradation of trichothecene mycotoxins by chicken intestinal microbes[J]. Food and Chemical Toxicology,2007,45:136−143. doi: 10.1016/j.fct.2006.07.028
[17]	曾凡正, 高阳, 李进伟, 等. 花生油生物精炼法去除黄曲霉毒素的研究[J]. 中国油脂,2012,37(1):6−10. [ZENG F Z, GAO Y, LI J W, et al. Removal of aflatoxin B₁ in peanut oil by bio-refining[J]. China Oils and Fats,2012,37(1):6−10.] doi: 10.3969/j.issn.1003-7969.2012.01.002 ZENG F Z, GAO Y, LI J W, et al. Removal of aflatoxin B₁ in peanut oil by bio-refining[J]. China Oils and Fats, 2012, 37（1）: 6−10. doi: 10.3969/j.issn.1003-7969.2012.01.002
[18]	ZACHETTI V G L, CENDOYA E, NICHEA M J. Preliminary study on the use of chitosan as an eco-friendly alternative to control fusarium growth and mycotoxin production on maize and wheat[J]. Pathogens,2019,8(1):29. doi: 10.3390/pathogens8010029
[19]	陈冉, 李培武, 马飞, 等. 花生黄曲霉毒素污染臭氧脱毒技术研究[J]. 中国油料作物学报,2013,35(1):92−96. [CHEN R, LI P W, MA F, et al. Aflatoxins detoxification in peanuts by ozonation[J]. Chinese Journal of Oil Crop Sciences,2013,35(1):92−96.] CHEN R, LI P W, MA F, et al. Aflatoxins detoxification in peanuts by ozonation[J]. Chinese Journal of Oil Crop Sciences, 2013, 35（1）: 92−96.
[20]	DIAO E J, HOU H X, CHEN B, et al. Ozonolysis efficiency and safety evaluation of aflatoxin B₁ in peanuts[J]. Food and Chemical Toxicology,2013,55:519−525. doi: 10.1016/j.fct.2013.01.038
[21]	姬宁. 花生油中黄曲霉毒素B₁碱炼脱毒及安全性评价[D]. 泰安:山东农业大学, 2015:42−51. [JI N. Alkali refining detoxification and safety evaluation of aflatoxin B₁ in peanut oil[D]. Taian:Shandong Agricultural University, 2015:42−51.] JI N. Alkali refining detoxification and safety evaluation of aflatoxin B₁ in peanut oil[D]. Taian: Shandong Agricultural University, 2015: 42−51.
[22]	APPELL M, JACKSON M A, DOMBRINK-KURTZMAN M A. Removal of patulin from aqueous solutions by propylthiol functionalized SBA-15[J]. Journal of Hazardous Materials,2011,187(1):150−156.
[23]	郑海燕. 挤压降解黄曲霉毒素B₁及作用机理研究[D]. 杨凌:西北农林科技大学, 2016:28−35. [ZHENG H Y. Extrusion degradation of aflatoxin B₁ and related mechanisms[D]. Yangling:Northwest A&F University, 2016:28−35.] ZHENG H Y. Extrusion degradation of aflatoxin B₁ and related mechanisms[D]. Yangling: Northwest A&F University, 2016: 28−35.
[24]	NEME K, MOHAMMED A. Mycotoxin occurrence in grains and the role of postharvest management as a mitigation strategies[J]. Food Control,2017,78:412−425. doi: 10.1016/j.foodcont.2017.03.012
[25]	AZIZ N, YOUSSEF B. Inactivation of naturally occurring of mycotoxins in some egyptian foods and agricultural commodities by gamma irradiation[J]. Egyptian Journal of Food Science,2002,3(1):167−177.
[26]	AZIZ N H, MOUSSA L A, FAR F M. Reduction of fungi and mycotoxins formation in seeds by gamma-radiation[J]. Journal of Food Safety,2004,24(2):109−127. doi: 10.1111/j.1745-4565.2004.tb00379.x
[27]	JALILI M, JINAP S, NORANIZAN M A. Aflatoxins and ochratoxin A reduction in black and white pepper by gamma radiation[J]. Radiation Physics & Chemistry,2012,81178:1786−1788.
[28]	BAIG N, IHSANULLAH, SAJID M, et al. Graphene-based adsorbents for the removal of toxic organic pollutants:A review[J]. Journal of Environmental Management,2019,244:370−382.
[29]	LI X Q, ZHU B, ZHU J. Graphene oxide based materials for desalination[J]. Carbon,2019,146:320−328. doi: 10.1016/j.carbon.2019.02.007
[30]	OLAD A, HAGH H B K. Graphene oxide and amin-modified graphene oxide incorporated chitosan gelatin scaffolds as promising materials for tissue engineering[J]. Composites Part B 2019, 162: 692−702.
[31]	PIROUZ A A, KARJIBAN R A, ABU B F, et al. A novel adsorbent magnetic graphene oxide modified with chitosan for the simultaneous reduction of mycotoxins[J]. Toxins,2018,10(9):361−369. doi: 10.3390/toxins10090361
[32]	BAI X, SUN C, XU J. et al. Detoxification of zearalenone from corn oil by adsorption of functionalized GO systems[J]. Applied Surface Science,2018,430:198−207. doi: 10.1016/j.apsusc.2017.06.055
[33]	刘亚杰, 孙淑敏, 卫敏. 磁性氧化石墨烯/二氧化钛对黄曲霉毒素B₁的吸附与光催化降解作用研究[J]. 河南工业大学学报,2021,42(4):1−8. [LIU Y J, SUN S M, WEI M. Study on the adsorption and photocatalytic degradation of aflatoxin B₁ by magnetic grapheneoxide/TiO₂[J]. Journal of Henan University of Technology (Natural Science Edition),2021,42(4):1−8.] LIU Y J, SUN S M, WEI M. Study on the adsorption and photocatalytic degradation of aflatoxin B₁ by magnetic grapheneoxide/TiO₂[J]. Journal of Henan University of Technology （Natural Science Edition）, 2021, 42（4）: 1−8.
[34]	LIU C, WANG J, WAN J J. MOF-on-MOF hybrids:Synthesis and applications[J]. Coordination Chemistry Reviews,2021,432:213743. doi: 10.1016/j.ccr.2020.213743
[35]	MA F, CAI X F, LI P W, et al. Adsorptive removal of aflatoxin b₁ from vegetable oils via novel adsorbents derived from a metal-organic framework[J]. Journal of Hazardous Materials,2021,412:125170. doi: 10.1016/j.jhazmat.2021.125170
[36]	SAMUEL M S, KIRANKUMAR V S, SELVARAJAN E. Fabrication of a metal-organic framework composite for removal of aflatoxin b₁ from water[J]. Journal of Environmental Chemical Engineering,2021,9:104966. doi: 10.1016/j.jece.2020.104966
[37]	LIU Y Q, SONG C G, DING G, et al. High-performance functional Fe-MOF for removing aflatoxin b1 and other organic pollutants[J]. Advanced Materials Interfaces,2022,9:2102480. doi: 10.1002/admi.202102480
[38]	CHENG J, WANG B, LI J R. Remarkable uptake of deoxynivalenol in stable metal-organic frameworks[J]. ACS Applied Materials & Interfaces,2021,13:58019−58026.
[39]	KARIMI Z, KARIMI L, SHOKROLLAHI H. Nano-magnetic particles used in biomedicine:Core and coating materials[J]. Materials Science and Engineering,2013,33(5):2465−2475. doi: 10.1016/j.msec.2013.01.045
[40]	KOLHATKAR A G, JAMISON A C, LITVINOV D, et al. Tuning the magnetic properties of nanoparticles[J]. International Journal of Molecular Sciences,2013,14(8):15977−16009. doi: 10.3390/ijms140815977
[41]	李银龙, 聂雪梅, 杨敏莉, 等. 新型磁性固相萃取材料在食品样品前处理中的应用进展[J]. 食品科学,2022,43(5):295−305. [LI Y L, NIE X M, YANG M L, et at. Overview on recent applications of novel magnetic solid-phase extraction materials for sample pretreatment for food analysis[J]. Food Science,2022,43(5):295−305.] LI Y L, NIE X M, YANG M L, et at. Overview on recent applications of novel magnetic solid-phase extraction materials for sample pretreatment for food analysis[J]. Food Science, 2022, 43（5）: 295−305.
[42]	LI W K, SHI Y P. Recent advances and applications of carbon nanotubes based composites in magnetic solid-phase extraction[J]. Trends in Analytical Chemistry,2019,118:652−665. doi: 10.1016/j.trac.2019.06.039
[43]	BAYRAC C, CAMIZCI G. Adsorptive removal of patulin from apple juice via sulfhydryl-terminated magnetic bead-based separation[J]. Journal of Hazardous Materials,2019,366:413−422. doi: 10.1016/j.jhazmat.2018.12.001
[44]	SUN J D, GUO W, SUN X L. Removal of patulin in apple juice based on novel magnetic molecularly imprinted adsorbent Fe₃O₄@SiO₂@CS-GO@MIP[J]. LWT-Food Science and Technology,2020,118:108854. doi: 10.1016/j.lwt.2019.108854
[45]	JI J M, XIE W L. Removal of aflatoxin b₁ from contaminated peanut oils using magnetic attapulgite[J]. Food Chemistry,2021,339:128072. doi: 10.1016/j.foodchem.2020.128072
[46]	JI J, XIE W. Detoxification of aflatoxin b1 by magnetic graphene composite adsorbents from contaminated oils[J]. Journal of Hazardous Materials,2020,381:120915. doi: 10.1016/j.jhazmat.2019.120915
[47]	MA S, PAN L G, WANG K, et al. G-C₃N₄/Fe₃O₄ nanocomposites as adsorbents analyzed by UPLC-MS/MS for highly sensitive simultaneous determination of 27 mycotoxins in maize:Aiming at increasing purification efficiency and reducing time[J]. Journal of Agricultural and Food Chemistry,2021,69(16):4874−4882. doi: 10.1021/acs.jafc.1c00141
[48]	VASCONCELOS I, FERNANDES C. Magnetic solid phase extraction for determination of drugs in biological matrices[J]. Trends in Analytical Chemistry,2017,89:41−52. doi: 10.1016/j.trac.2016.11.011
[49]	马帅, 由天艳, 潘立刚, 等. 石墨相氮化碳在食品分析前处理制备技术中的发展和应用[J]. 食品科学,2020,41(19):296−302. [MA S, YOU T Y, WANG L G, et at. A review of the development and application of graphite phase carbon nitride in sample pretreatment techniques for food analysis[J]. Food Science,2020,41(19):296−302.] doi: 10.7506/spkx1002-6630-20191018-181 MA S, YOU T Y, WANG L G, et at. A review of the development and application of graphite phase carbon nitride in sample pretreatment techniques for food analysis[J]. Food Science, 2020, 41（19）: 296−302. doi: 10.7506/spkx1002-6630-20191018-181

Supplements (1)

Supplements
Other Related Supplements

Cited By

Cited by

Periodical cited type(4)

1.	杨玺钰，黎晓阳. 固定化酶技术在食品真菌毒素脱除中的应用. 食品安全质量检测学报. 2025(06): 224-231 .
2.	宋佳淇，吕鹏雯，李雪楠. 玉米中真菌毒素的富集规律及脱毒研究进展. 农产品加工. 2025(06): 74-81 .
3.	丁学妍，邵瑞婷，姜洁. 超高效液相色谱-串联质谱法测定食用植物酵素中33种真菌毒素. 食品与发酵工业. 2024(24): 339-345 .
4.	郑圣乐，李卓颖，王家浩，刘峻铭，方桂娇，韩鹿. 益生菌清除食品毒素的研究进展. 农产品加工. 2024(21): 129-134+139 .