Preparation of Peppermint Oil/<i>β</i>-CD Inclusion by High-speed Shearing with Process Optimization Using ResponseSurface Methodology

CHEN Hongbin; HONG Lunbo; WANG Juan; XU Jianbing; YANG Xiaoming; WU Xiaohui

doi:10.13386/j.issn1002-0306.2023020138

Volume 44 Issue 22

Nov. 2023

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Science and Technology of Food Industry > 2023 > 44(22): 210-218. > DOI: 10.13386/j.issn1002-0306.2023020138

CHEN Hongbin, HONG Lunbo, WANG Juan, et al. Preparation of Peppermint Oil/β-CD Inclusion by High-speed Shearing with Process Optimization Using ResponseSurface Methodology[J]. Science and Technology of Food Industry, 2023, 44(22): 210−218. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023020138.

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Preparation of Peppermint Oil/β-CD Inclusion by High-speed Shearing with Process Optimization Using ResponseSurface Methodology

1.
Zhejiang Huisong Pharmaceutical Company Limited, Hangzhou 310020, China
2.
College of Food and Biological Engineering, Jiangsu University, 212013, China

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Received Date: February 14, 2023
Available Online: September 16, 2023

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Abstract

Abstract

Objective: To investigate the optimal process for preparing peppermint essential oil/β-cyclodextrin (β-CD) inclusion complex using high-speed shearing combined with freeze-drying. Methods: The effects of freeze-drying and vacuum drying, high-speed shearing, and stirring on the encapsulation process were compared. Based on single-factor experiments, the ratio of β-CD to essential oil, encapsulation temperature, and mass fraction of β-CD were considered as influencing factors. The comprehensive score of oil content and encapsulation efficiency was used as an evaluation index to investigate the Box-Behnken response surface method for optimizing the encapsulation process. The content of pulegone in the inclusion complex was measured by high-performance liquid chromatography (HPLC). Fourier transform infrared spectroscopy (FTIR) was used to characterize the inclusion complex. Results: The yield of inclusion complex prepared by freeze-drying was higher, with an average yield of 97.6%. The oil content and encapsulation efficiency by the high-speed shearing method were relatively high, being about 3% and 19% higher than those by the stirring method, respectively. The optimized conditions were as follows: The weight ratio of β-CD to volatile oil was 9:1 (g/mL), the encapsulation temperature was 55 ℃, and the mass fraction of β-CD was 17%. Under these conditions, the essential oil content was 10.9%, the encapsulation efficiency was 97.6%, the comprehensive score was 99.7, the RSD value was 1.59%, and the optimized process was stable and feasible. The content of pulegone in the inclusion complex was found to be 2.465 mg/g by HPLC. The formation of the peppermint oil/β-CD inclusion complex was confirmed by analysis using FTIR. Conclusion: The combination of high-speed shearing and freeze-drying for the preparation of peppermint essential oil inclusion complex had the advantages of high efficiency, simple process, and it improved theyield, would provide guidance for the production process.
- peppermint essential oil,
- β-cyclodextrin inclusion,
- high-speed shearing,
- freeze-drying,
- Box-Behnken response surface,
- FTIR

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