Adjuvant Prevention of Type 2 Diabetes of <i>Citrus</i> Peel Based on Bionetwork Analysis

ZHANG Yan; YAN Ping; ZHANG Hua; ZHANG Han; ZHENG Mengdi; CHAI Xiyan

doi:10.13386/j.issn1002-0306.2023010158

Volume 45 Issue 5

Feb. 2024

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Science and Technology of Food Industry > 2024 > 45(5): 319-330. > DOI: 10.13386/j.issn1002-0306.2023010158

ZHANG Yan, YAN Ping, ZHANG Hua, et al. Adjuvant Prevention of Type 2 Diabetes of Citrus Peel Based on Bionetwork Analysis[J]. Science and Technology of Food Industry, 2024, 45(5): 319−330. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2023010158.

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Adjuvant Prevention of Type 2 Diabetes of Citrus Peel Based on Bionetwork Analysis

1.
Xi’an Medical University, Xi’an 710021, China
2.
Xi'an Yurun Baide Health Management Co., Ltd., Xi’an 710065, China

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Received Date: February 08, 2023
Available Online: January 03, 2024

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Abstract

Abstract

Objective: To elucidate the main components and mechanism of adjuvant prevention of type 2 diabetes of Citrus peel. Methods: The inhibitory activity of Citrus peel of α-glycosidase was determined in vitro. It were used to predict the material basis and potential mechanism of Citrus peel in the treatment of type 2 diabetes by network pharmacology, and verified the results by molecular docking. Results: The α-glucosidase was inhibited by 13 kinds of Citrus peel and showed a dose-effect relationship in the linear range. It was predicted that the active ingredients naringin, tangeretin and lauric acid might inhibit hyperglycemia through oxidative stress by network pharmacology and molecular docking. Citrus peel treatment of type Ⅱ diabetes was related to PI3K-Akt, Ras, HIF-1 signaling pathway in inflammation and vascular related VEGF signaling pathway. Tangeretin was the main component. Conclusion: Citrus peel had an inhibitory effect on α-glycosidase , which might play a role in the prevention of type 2 diabetes.
- Citrus peel,
- enzyme inhibition,
- network pharmacology,
- hypoglycemic effect

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