Correlation Analysis between the Active Ingredients and the Antioxidant or Cholate-binding Ability of Ethanol Extracts from <i>Psoralea corylifolia</i> L.

JIANG Xinyang; LIANG Jinyue; SHI Jitong; LIU Lanling; ZHANG Shanshan; ZHAO Pan; YAN Peizheng; ZHAO Dongsheng

doi:10.13386/j.issn1002-0306.2022010218

Volume 43 Issue 13

Jun. 2022

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Science and Technology of Food Industry > 2022 > 43(13): 381-388. > DOI: 10.13386/j.issn1002-0306.2022010218

JIANG Xinyang, LIANG Jinyue, SHI Jitong, et al. Correlation Analysis between the Active Ingredients and the Antioxidant or Cholate-binding Ability of Ethanol Extracts from Psoralea corylifolia L. DOI: 10.13386/j.issn1002-0306.2022010218

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Correlation Analysis between the Active Ingredients and the Antioxidant or Cholate-binding Ability of Ethanol Extracts from Psoralea corylifolia L.

1.
College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
2.
Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan 250355, China

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Received Date: January 24, 2022
Available Online: June 09, 2022

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Objective: The contents of main active ingredients, antioxidant and cholate binding ability of different ethanol extracts from Psoralea corylifolia L. were explored based on the mode of correlation of “components-efficacy”. Methods: Psoralea corylifolia L. was extracted with anhydrous ethanol, 75% ethanol, 50% ethanol and water. The contents of total flavonoids and total polyphenols in Psoralea corylifolia L. were determined. The antioxidant and lipid-lowering activities in vitro of Psoralea corylifolia L. were evaluated by three antioxidant systems and the binding ability of cholate salts, respectively, and the correlation analysis was conducted. Results: The contents of total flavonoids and total polyphenols in anhydrous ethanol extract were the highest, (50.317±0.018) mg/g and (3.860±0.045) mg/g, respectively. The 50% ethanol extract showed the best ability to scavenge ABTS^＋· and DPPH·, the IC₅₀ values were 0.76 and 1.63 mg/mL, respectively. The anhydrous ethanol extract showed the strongest reducing ability, the A_0.5 value was 2.63 mg/mL. The water extract showed the strongest binding capacity to sodium cholate, the IC₅₀ value was 0.67 mg/mL. The 50% ethanol extract showed the strongest binding capacity to sodium taurocholate and sodium glycinate, the IC₅₀ values were 1.26 and 0.41 mg/mL, respectively. The correlation results showed that the content of total flavonoids of different ethanol extracts from Psoralea corylifolia L. had a significant positive correlation with DPPH· clearance rate and sodium taurocholate binding rate (P<0.05). And the content of total flavonoids and total polyphenols had a very significant positive correlation with reduction ability (P<0.01). While the content of total polyphenols had a significant negative correlation with sodium cholate binding rate (P<0.05). Conclusion : The 50% ethanol extract of Psoralea corylifolia L. has high content of active ingredients and the strongest antioxidant and cholate binding ability. It can be used as a potential important source of natural antioxidant and lipid-lowering active substances.
- Psoralea corylifolia L.,
- ethanol extracts,
- antioxidant,
- cholate,
- correlation analysis,
- hypolipidemic

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