Science and Technology of Food Industry

ISSN 1002-0306
CN   11-1759/TS
High-quality sci-tech periodicals
Menu
Volume 43 Issue 13
Jun.  2022
Turn off MathJax
Article Contents
Abstract
References
JIANG Xinyang, LIANG Jinyue, SHI Jitong, et al. Correlation Analysis between the Active Ingredients and the Antioxidant or Cholate-binding Ability of Ethanol Extracts from Psoralea corylifolia L. DOI: 10.13386/j.issn1002-0306.2022010218
Citation: JIANG Xinyang, LIANG Jinyue, SHI Jitong, et al. Correlation Analysis between the Active Ingredients and the Antioxidant or Cholate-binding Ability of Ethanol Extracts from Psoralea corylifolia L. DOI: 10.13386/j.issn1002-0306.2022010218
shu

Correlation Analysis between the Active Ingredients and the Antioxidant or Cholate-binding Ability of Ethanol Extracts from Psoralea corylifolia L.

  • 1.

    College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China

  • 2.

    Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan 250355, China

More Information
  • Received Date: January 24, 2022
  • Available Online: June 09, 2022
    Graphical Abstract
    • Abstract
  • Objective: The contents of main active ingredients, antioxidant and cholate binding ability of different ethanol extracts from Psoralea corylifolia L. were explored based on the mode of correlation of “components-efficacy”. Methods: Psoralea corylifolia L. was extracted with anhydrous ethanol, 75% ethanol, 50% ethanol and water. The contents of total flavonoids and total polyphenols in Psoralea corylifolia L. were determined. The antioxidant and lipid-lowering activities in vitro of Psoralea corylifolia L. were evaluated by three antioxidant systems and the binding ability of cholate salts, respectively, and the correlation analysis was conducted. Results: The contents of total flavonoids and total polyphenols in anhydrous ethanol extract were the highest, (50.317±0.018) mg/g and (3.860±0.045) mg/g, respectively. The 50% ethanol extract showed the best ability to scavenge ABTS＋· and DPPH·, the IC50 values were 0.76 and 1.63 mg/mL, respectively. The anhydrous ethanol extract showed the strongest reducing ability, the A0.5 value was 2.63 mg/mL. The water extract showed the strongest binding capacity to sodium cholate, the IC50 value was 0.67 mg/mL. The 50% ethanol extract showed the strongest binding capacity to sodium taurocholate and sodium glycinate, the IC50 values were 1.26 and 0.41 mg/mL, respectively. The correlation results showed that the content of total flavonoids of different ethanol extracts from Psoralea corylifolia L. had a significant positive correlation with DPPH· clearance rate and sodium taurocholate binding rate (P<0.05). And the content of total flavonoids and total polyphenols had a very significant positive correlation with reduction ability (P<0.01). While the content of total polyphenols had a significant negative correlation with sodium cholate binding rate (P<0.05). Conclusion : The 50% ethanol extract of Psoralea corylifolia L. has high content of active ingredients and the strongest antioxidant and cholate binding ability. It can be used as a potential important source of natural antioxidant and lipid-lowering active substances.
    • FullText(HTML)
    • References (35)
  • [1]
    GAO H T Y, LANG G Z, ZANG Y D, et al. Bioactive monoterpene phenol dimers from the fruits of Psoralea corylifolia L.[J]. Bioorg Chem,2021,112:104924. doi: 10.1016/j.bioorg.2021.104924
    [2]
    CHOPRA B, DHINGRA A K, DHAR K L. Psoralea corylifolia L. (Buguchi)-folklore to modern evidence: Review[J]. Fitoterapia,2013,90:44−56. doi: 10.1016/j.fitote.2013.06.016
    [3]
    ZHANG X N, ZHAO W W, WANG Y, et al. The chemical constituents and bioactivities of Psoralea corylifolia Linn. : A review[J]. Am J Chin Med,2016,44:35−60. doi: 10.1142/S0192415X16500038
    [4]
    QIAO C F, HAN Q B, SONG J Z, et al. Chemical fingerprint and quantitative analysis of fructus psoraleae by high-performance liquid chromatography[J]. J Sep Sci,2007,30:813−818. doi: 10.1002/jssc.200600339
    [5]
    陈建平, 谢皓玥, 周际宇. 高效液相色谱-串联质谱法同时测定保健食品中淫羊藿苷、金丝桃苷、补骨脂素[J]. 食品安全质量检测学报,2021,12(1):192−196. [CHEN J P, XIE H Y, ZHOU J Y. Simultaneous determination of icariin, hyperoside and psoralen in functional food by high performance liquid chromatographytandem mass spectrometry[J]. Journal of Food Safety & Quality,2021,12(1):192−196.

    CHEN J P, XIE H Y, ZHOU J Y. Simultaneous determination of icariin, hyperoside and psoralen in functional food by high performance liquid chromatographytandem mass spectrometry[J]. Journal of Food Safety & Quality, 2021, 12(1): 192-196.
    [6]
    鲁亚奇, 张晓, 王金金, 等. 补骨脂化学成分及药理作用研究进展[J]. 中国实验方剂学杂志,2019,25(3):180−189. [LU Y Q, ZHANG X, WANG J J, et al. Research progress on chemical constituents and pharmacological effects of Psoraleae Fructus[J]. Chinese Journal of Experimental Traditional Chinese Medicine,2019,25(3):180−189.

    LU Y Q, ZHANG X, WANG J J, et al. Research progress on chemical constituents and pharmacological effects of Psoraleae Fructus[J]. Chinese Journal of Experimental Traditional Chinese Medicine, 2019, 25(3): 180-189.
    [7]
    魏蒙蒙, 王树瑶, 杨维, 等. 补骨脂的化学成分及主要毒性研究进展[J]. 中国实验方剂学杂志,2019,25(7):207−219. [WEI M M, WANG S Y, YANG W, et al. Chemical constituents of Psoraleae Fructus and its main toxic ingredients[J]. Chinese Journal of Experimental Formulae,2019,25(7):207−219.

    WEI M M, WANG S Y, YANG W, et al. Chemical constituents of Psoraleae Fructus and its main toxic ingredients[J]. Chinese Journal of Experimental Formulae, 2019, 25(7): 207-219.
    [8]
    RAJENDRA P N, ANANDI C, BALASUBRAMANIAN S, et al. Antidermatophytic activity of extracts from Psoralea corylifolia (Fabaceae) correlated with the presence of a flavonoid compound[J]. J Ethnopharmacol,2004,91:21−24. doi: 10.1016/j.jep.2003.11.010
    [9]
    KOUL B, TAAK P, KUMAR A, et al. Genus Psoralea: A review of the traditional and modern uses, phytochemistry and pharmacology[J]. J Ethnopharmacol,2019,232:201−226. doi: 10.1016/j.jep.2018.11.036
    [10]
    胡栋宝, 罗丽昌, 杨猛, 等. 不同溶剂提取黑牛肝菌中的多酚及抗氧化活性的比较研究[J]. 食用菌,2020,42(6):69−72. [HU D B, LUO L C, YANG M, et al. A comparative study on extracting polyphenol and antioxidant activity of polyphenol from Boletus aereus by different solvents[J]. Edible Fungi,2020,42(6):69−72. doi: 10.3969/j.issn.1000-8357.2020.06.026

    HU D B, LUO L C, YANG M, et al. A comparative study on extracting polyphenol and antioxidant activity of polyphenol from Boletus aereus by different solvents[J]. Edible fungi, 2020, 42(6): 69-72. doi: 10.3969/j.issn.1000-8357.2020.06.026
    [11]
    廖霞, 吴振, 杨勇, 等. 乌天麻不同溶剂提取物的总多酚、总黄酮含量及其抗氧化能力评价[J/OL]. 食品与发酵工业: 1−9 [2022-01-22]. DOI: 10.13995/j.cnki.11-1802/ts.027943.

    LIAO X, WU Z, YANG Y, et al. Total polyphenols, total flavonoids contents and antioxidant capacities of different solvents extracts from Gastrodia elata Bl. f. glauca S. Chow[J]. Food and Fermentation Industries: 1−9 [2022-01-22]. DOI: 10.13995/j.cnki.11-1802/ts.027943.
    [12]
    赵益业, 蔡宇, 冯笑珍, 等. 回流法与超声法提取补骨脂总黄酮的比较研究[J]. 中药材,2008(5):769−770. [ZHAO Y Y, CAI Y, FENG X Z, et al. Comparative study on extraction of total flavonoids from psoralen by reflux method and ultrasonic method[J]. Chinese Medicinal Materials,2008(5):769−770. doi: 10.3321/j.issn:1001-4454.2008.05.049

    ZHAO Y Y, CAI Y, FENG X Z, et al. Comparative study on extraction of total flavonoids from psoralen by reflux method and ultrasonic method[J]. Chinese Medicinal Materials, 2008(5): 769-770. doi: 10.3321/j.issn:1001-4454.2008.05.049
    [13]
    鲁宪坤, 翟鑫源, 李方红, 等. 补骨脂总黄酮提取工艺的优化[J]. 中成药,2022,44(1):193−197. [LU X K, ZHAI X Y, LI F H, et al. Optimization of extraction process of total flavonoids from psoralen[J]. Chinese Patent Medicine,2022,44(1):193−197. doi: 10.3969/j.issn.1001-1528.2022.01.036

    LU X K, ZHAI X Y, LI F H, et al. Optimization of extraction process of total flavonoids from psoralen[J]. Chinese Patent Medicine, 2022, 44(1): 193-197. doi: 10.3969/j.issn.1001-1528.2022.01.036
    [14]
    王凯燕, 耿子凯, 刘莉, 等. 补骨脂不同溶剂提取物对前列腺增生小鼠干预作用比较[J]. 山东中医药大学学报,2019,43(6):594−598. [WANG K Y, GENG Z K, LIU L, et al. Comparison of intervention effect of different solvent extracts of buguzhi (Psoraleae Fructus) on mice with Benign Prostatic Hyperplasia[J]. Journal of Shandong University of Traditional Chinese Medicine,2019,43(6):594−598.

    WANG K Y, GENG Z K, LIU L, et al. Comparison of intervention effect of different solvent extracts of buguzhi(Psoraleae Fructus)on mice with Benign Prostatic Hyperplasia[J]. Journal of Shandong University of Traditional Chinese Medicine, 2019, 43(6): 594-598.
    [15]
    林萍萍, 陈明珠, 张吟. 补骨脂及其主要化学成分降糖机制的研究进展[J/OL]. 中国中药杂志: 1−10 [2022-03-02]. DOI:10.19540/j.cnki.cjcmm. 20211229.701.

    LIN P P, CHEN M Z, ZHANG Y. Hypoglycemic mechanism of Psoraleae Fructus and its main chemical constituents[J/OL]. China Journal of Traditional Chinese Medicine: 1−10 [2022-03-02]. DOI: 10.19540/j.cnki.cjcmm.20211229.701.
    [16]
    常爱冰, 刘妍如, 王梅, 等. 基于“甾酮类化学成分-抗氧化生物活性”关联分析评价牛膝药材商品等级[J]. 天然产物研究与开发,2020,32(10):1737−1746. [CHANG A B, LIU Y R, WANG M, et al. Commercial grade evaluation of Achyranthes bidentata based on "phytoecdysones components-antioxidant biological activity" correlation[J]. Natural Product Research and Development,2020,32(10):1737−1746.

    CHANG A B, LIU Y R, WANG M, et al. Commercial grade evaluation of Achyranthes bidentata based on "phytoecdysones components-antioxidant biological activity" correlation[J]. Natural Product Research and Development, 2020, 32(10): 1737 -1746.
    [17]
    秦月雯, 侯金丽, 王萍, 等. 马齿苋“成分-活性-中药功效-疾病”研究进展及关联分析[J]. 中草药,2020,51(7):1924−1938. [QIN Y W, HOU J L, WANG P, et al. Research progress and correlation analysis on “phytochemistry-pharmacological effects-CMM efficacy-diseases”of Portulaca oleracea[J]. Chinese Herbal Medicine,2020,51(7):1924−1938. doi: 10.7501/j.issn.0253-2670.2020.07.030

    QIN Y W, HOU J L, WANG P, et al. Research progress and correlation analysis on “phytochemistry-pharmacological effects-CMM efficacy-diseases”of Portulaca oleracea[J]. Chinese Herbal Medicine, 2020, 51(7): 1924-1938. doi: 10.7501/j.issn.0253-2670.2020.07.030
    [18]
    裴文清, 吕泸楠, 王靖宇, 等. 木瓜皮多酚和黄酮提取工艺优化及酪氨酸酶与胰脂肪酶抑制活性研究[J]. 食品工业科技,2022,43(1):188−195. [PEI W Q, LYU L N, WANG J Y, et al. Optimization of extraction of polyphenols and flavonoids from papaya peel and its anti-tyrosinase and anti-pancreatic lipase[J]. Science and Technology of Food Industry,2022,43(1):188−195.

    PEI W Q, LU L N, WANG J Y, et al. Optimization of extraction of polyphenols and flavonoids from papaya peel and its anti-tyrosinase and anti-pancreatic lipase[J]. Science and Technology of Food Industry, 2022, 43(1): 188-195.
    [19]
    崔施展, 谢晓亮, 贾东升, 等. 黑枸杞不同溶剂提取物抗氧化活性[J]. 食品研究与开发,2017,38(9):38−41. [CUI S Z, XIE X L, JIA D S, et al. Antioxidant activity of extracts from different solvents of black wolfberry[J]. Food Research and Development,2017,38(9):38−41. doi: 10.3969/j.issn.1005-6521.2017.09.009

    CUI S Z, XIE X L, JIA D S, et al. Antioxidant activity of extracts from different solvents of black wolfberry[J]. Food Research and Development, 2017, 38(9): 38-41. doi: 10.3969/j.issn.1005-6521.2017.09.009
    [20]
    杨美莲, 程桂广, 蔡圣宝, 等. 朝鲜蓟叶多酚提取及抗氧化活性研究[J]. 现代食品科技,2019,35(4):157−165, 21. [YANG M L, CHENG G G, CAI S B, et al. Extraction and antioxidant activity of polyphenols from Artichoke leaves[J]. Modern Food Science and Technology,2019,35(4):157−165, 21.

    YANG M L, CHENG G G, CAI S B, et al. Extraction and antioxidant activity of polyphenols from Artichoke leaves[J]. Modern Food Science and Technology, 2019, 35(4): 157-165, 21.
    [21]
    慕钰文, 黄玉龙, 张辉元. 花椒籽不同溶剂提取物的活性成分及抗氧化性比较[J]. 包装与食品机械,2021,39(3):21−26. [MU Y W, HUANG Y L, ZHANG H Y. Bioactive compounds extracted with different solvents from Zanthoxylum bungeanum Maxim. seeds and comparison of their antioxidant activities[J]. Packaging and Food Machinery,2021,39(3):21−26. doi: 10.3969/j.issn.1005-1295.2021.03.004

    MU Y W, HUANG Y L, ZHANG H Y. Bioactive compounds extracted with different solvents from Zanthoxylum Bungeanum Maxim. seeds and comparison of their antioxidant activities[J]. Packaging and Food Machinery, 2021, 39(3): 21-26. doi: 10.3969/j.issn.1005-1295.2021.03.004
    [22]
    黎善铭, 桂海霞, 梅朋飞, 等. 毛薯多糖提取分离工艺优化及抗氧化活性研究[J/OL]. 热带作物学报: 1−11 [2022-01-23]. http://kns.cnki.net/kcms/detail/46.1019.S.20211026.2212.002.html.

    LI S M, GUI H X, MEI P F, et al. Extraction, isolation, process optimization and anti-oxidant activity of polysaccharides from Dioscorea esculenta[J/OL]. Journal of tropical crops: 1−11 [2022-01-23]. http://kns.cnki.net/kcms/detail/46.1019.S.20211026.2212.002.html.
    [23]
    李珊, 刘耀耀, 刘哲, 等. 狭果茶藨子黄酮提取工艺优化及其体外降血脂活性[J]. 食品研究与开发,2021,42(3):73−79. [LI S, LIU Y Y, LIU Z, et al. Optimization of the extraction process of flavonoids from Ribes stenocarpum Maxim. and its hypolipidemic activity in vitro[J]. Food Research and Development,2021,42(3):73−79.

    LI S , LIU Y Y, LIU Z, et al. Optimization of the extraction process of flavonoids from Ribes stenocarpum Maxim. and its hypolipidemic activity in vitro[J]. Food Research and Development, 2021, 42(3): 73-79.
    [24]
    李婧雯, 包怡红. 不同溶剂的蒲公英根提取物的抗氧化活性及降糖能力比较分析[J]. 现代食品科技,2020,36(5):64−72. [LI J W, BAO Y H. Comparative analysis of antioxidant and hypoglycemic aapabilities of Taraxacum mongolicum root extracts in different solvents[J]. Modern Food Science and Technology,2020,36(5):64−72.

    LI J W, BAO Y H. Comparative analysis of antioxidant and hypoglycemic aapabilities of Taraxacum Mongolicum root extracts in different solvents[J]. Modern Food Science and Technology, 2020, 36(5): 64-72.
    [25]
    师聪, 宫号, 李茹, 等. 草果不同极性萃取物总黄酮、总多酚含量与其抗氧化活性的相关性[J]. 化学试剂,2022,44(1):84−89. [SHI C, GONG H, LI R, et al. Correlation between total flavonoids, total polyphenols and antioxidant activity of different extracts fromFructus herba[J]. Chemical Reagents,2022,44(1):84−89.

    SHI C, GONG H, LI R, et al. Correlation between total flavonoids, total polyphenols and antioxidant activity of different extracts from Fructus herba[J]. Chemical Reagents, 2022, 44(1): 84-89.
    [26]
    师聪, 解春芝, 张建萍, 等. 覆盆子不同极性溶剂提取物的抗氧化活性比较[J]. 食品科技,2021,46(1):220−224. [SHI C, XIE C Z, ZHANG J P, et al. Comparison of antioxidant activities of different solvent extracts from raspberry[J]. Food Science and Technology,2021,46(1):220−224.

    SHI C, XIE C Z, ZHANG J P, et al. Comparison of antioxidant activities of different solvent extracts from Raspberry[J]. Food Science and Technology, 2021, 46(1): 220-224.
    [27]
    李春爱, 田立鹏, 蔡梦, 等. 橄榄果渣乙醇提取物成分分析及抗氧化和抑菌性能研究[J]. 天然产物研究与开发,2022,34(1):7−15. [LI C A, TIAN L P, CAI M, et al. Study on the component, antioxidant and antibacterial properties of ethanol extract from olive pomace[J]. Natural Product Research and Development,2022,34(1):7−15.

    LI C A, TIAN L P, CAI M, et al. Study on the component, antioxidant and antibacterial properties of ethanol extract from olive pomace[J]. Natural Product Research and Development, 2022, 34(1): 7-15.
    [28]
    姚旭, 郦萍, 顾青. 4种甜橙皮黄酮类化合物体外抗氧化活性及降糖降脂功能研究[J]. 中国食品学报,2022,22(1):49−57. [YAO X, LI P, GU Q. Studies on antioxidant activity, hypoglycemic and lipid-lowering capacity of flavonoids in sweet orange peels in vitro[J]. Chinese Journal of Food Science,2022,22(1):49−57.

    YAO X, LI P, GU Q. Studies on antioxidant activity, hypoglycemic and lipid-lowering capacity of flavonoids in sweet orange peels in vitro[J]. Chinese Journal of Food Science, 2022, 22(1): 49-57.
    [29]
    李井雷, 刘玉婷, 宗帅, 等. 羊肚菌胞外多糖体外降血糖降血脂活性研究[J]. 食品研究与开发,2020,41(16):39−45. [LI J L, LIU Y T, ZONG S, et al. In vitro hyperglycemic and hypolipidemic activity of Morchella esculenta extracellular polysaccharides[J]. Food Research and Development,2020,41(16):39−45. doi: 10.12161/j.issn.1005-6521.2020.16.006

    LI J L, LIU Y T, ZONG S, et al. In vitro hyperglycemic and hypolipidemic activity of Morchella esculenta extracellular polysaccharides[J]. Food Research and Development, 2020, 41(16): 39-45. doi: 10.12161/j.issn.1005-6521.2020.16.006
    [30]
    吕冰冰, 谢笔钧, 孙智达. 红肉番石榴果胶的理化特性及其体外降脂作用[J]. 食品工业科技,2021,42(20):51−60. [LYV B B, XIE B J, SUN Z D. Physical and chemical properties of red-flesh guava pectin and its lipid-lowering effect in vitro[J]. Science and Technology of Food Industry,2021,42(20):51−60.

    LV B B, XIE B J, SUN Z D. Physical and chemical properties of red-flesh guava pectin and its lipid-lowering effect in vitro[J]. Science and Technology of Food Industry, 2021, 42(20): 51-60.
    [31]
    林沛纯, 谌素华, 郑素丽. 亨氏马尾藻岩藻聚糖的提取及体外吸附胆酸盐的作用[J]. 食品工业科技,2020,41(17):58−61, 67. [LIN P C, CHEN S H, ZHENG S L. Extraction of fucoidan from Sargassum henslowianum and its binding effect on binding bile salts in vitro[J]. Science and Technology of Food Industry,2020,41(17):58−61, 67.

    LIN P C, CHEN S H, ZHENG S L. Extraction of fucoidan from Sargassum henslowianum and its binding effect on binding bile salts in vitro[J]. Science and Technology of Food Industry, 2020, 41(17): 58-61, 67.
    [32]
    唐茹萌, 焦文雅, 桑亚新, 等. 裙带菜多糖体外和体内降血脂活性[J]. 食品科学,2022,43(1):142−149. [TANG R M, JIAO W Y, SANG Y X, et al. In vitro and in vivo hypolipidemic effect of Undaria pinnatifida polysaccharide[J]. Food Science,2022,43(1):142−149.

    TANG R M, JIAO W Y, SANG Y X, et al. In vitro and in vivo hypolipidemic effect of Undaria pinnatifida polysaccharide[J]. Food Science, 2022, 43(1): 142-149.
    [33]
    赵有伟, 李德海. 超声微波协同制备粗毛纤孔菌多糖及体外降脂作用的研究[J]. 食品工业科技,2021,42(20):191−198. [ZHAO Y W, LI D H. Ultrasonic and microwave synergistic preparation of polysaccharide from Inonotus hispidus and its effect on lowering lipid in vitro[J]. Food Industry Science and Technology,2021,42(20):191−198.

    ZHAO Y W, LI D H. Ultrasonic and microwave synergistic preparation of polysaccharide from Inonotus hispidus and its effect on lowering lipid in vitro[J]. Food Industry Science and Technology, 2021, 42(20): 191-198.
    [34]
    古丽米热·祖努纳, 王伟雄, 吕泽, 等. 药桑葡萄酒发酵工艺优化及体外抗氧化与结合胆酸盐能力研究[J/OL]. 食品工业科技: 1−17 [2022-01-23]. DOI: 10.13386/j.issn1002-0306.2021060236

    GULEMIRE Z, WANG W X, LYU Z, et al. Optimization of fermentation process of grape medicine mulberry wine and its antioxidant and bile acid binding capacity in vitro[J]. Science and Technology of Food Industry: 1−17 [2022-01-23]. DOI: 10.13386/j.isssn1002-0306.2021060236.
    [35]
    张天凤, 张振山, 王帅, 等. 亚麻籽粕提取物抗氧化成分及抗氧化活性研究[J]. 粮食与油脂,2021,34(12):137−141. [ZHANG T F, ZHANG Z S, WANG S, et al. Study on antioxidant components and antioxidant activity of flaxseed meal extract[J]. Grain and Oil,2021,34(12):137−141. doi: 10.3969/j.issn.1008-9578.2021.12.032

    ZHANG T F, ZHANG Z S, WANG S, et al. Study on antioxidant components and antioxidant activity of flaxseed meal extract[J]. Grain and Oil, 2021, 34(12): 137-141. doi: 10.3969/j.issn.1008-9578.2021.12.032
    • Related Articles
  • Supplements (0)

  • Cited by

    Periodical cited type(17)

    1. 胡一杰，刘杏宜，刘剑，邝金文，徐中岳. 我国保健食品功能声称存在的问题及发展对策研究. 卫生软科学. 2025(03): 49-53 .
    2. 杨帅，郑林，迟明艳，巩仔鹏，李月婷，魏茂陈，黄勇. UPLC-MS/MS法同时测定阿胶中18种核苷、游离氨基酸的含量. 中成药. 2024(07): 2140-2146 .
    3. 蒲健，杨帅，祝扬帆，谭丹，郑林，迟明艳，黄勇. UPLC-MS/MS法同时测定阿胶中20种氨基酸含量及其化学模式识别分析. 中国药业. 2024(22): 87-94 .
    4. 云振宇，吴琦，兰韬，赵琳，周紫梦. 基于高质量发展的我国保健食品标准化工作现状、问题分析及展望. 食品工业科技. 2023(08): 476-484 . 本站查看
    5. 陈建平，何颂捷，谢皓玥，胡凤，谭文渊. 超高效液相色谱-三重四级杆质谱法测定保健食品中六种功能成分. 食品与发酵科技. 2023(02): 124-130 .
    6. 陶瑞，刘晨晨，王远远，刘柱. 保健食品检测技术指导原则解读及发展方向探讨. 食品安全质量检测学报. 2023(14): 166-174 .
    7. 王超，张潇予，祝波，杨钊. 高效液相色谱-串联四级杆质谱法测定保健食品中氯化高铁血红素. 中国食品添加剂. 2023(11): 197-201 .
    8. 史敏. 保健食品功效成分检测技术与方法. 食品安全导刊. 2023(32): 166-168 .
    9. 姜雨，李菲菲，付雨，李雨虹，尹秀文. 辅酶Q10类保健食品注册审评审批状况分析与建议. 食品工业科技. 2022(08): 264-272 . 本站查看
    10. 魏素珍. 具有保护肺功能的保健食品功能学检测方法研究. 中国食品工业. 2022(07): 118-121 .
    11. 袁利杰，纵伟. 超高效液相色谱-四极杆/轨道阱高分辨质谱法快速筛查功能性保健食品中19种特征性成分. 食品安全质量检测学报. 2022(20): 6518-6527 .
    12. 陈建平，冉渺，谢皓玥，田富丽. 超高效液相质谱法测定增强免疫类中药保健食品中多种功能成分含量. 中药与临床. 2022(06): 29-33 .
    13. 张再平，吴莉，方方，冯有龙，曹玲. 超高效液相色谱法同时测定芦荟保健食品中8种蒽醌类成分的含量. 食品科技. 2021(04): 291-295 .
    14. 田明，孙璐，李昱霏，胡昊，冯军. 基于国际经验探究中国保健食品原料管理研究. 食品工业科技. 2021(13): 21-25 . 本站查看
    15. 田明，尹淑涛，闫志刚，薛天. 澳大利亚补充药品管理及对我国保健食品监管启示研究. 食品安全质量检测学报. 2021(11): 4438-4445 .
    16. 王倩，刘睿，朱悦，杨滨，丁玉华，白加德，温华军，吴海荣，段金廒，赵明. 麋鹿角中核苷类和氨基酸类成分区域差异性分析. 中国中药杂志. 2021(14): 3494-3503 .
    17. 袁利杰. 河南省2018年—2020年保健食品抽检结果分析. 中国卫生检验杂志. 2021(23): 2909-2913 .

    Other cited types(6)

Catalog

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (229) PDF downloads (11) Cited by(23)
    Address：No. 70, Shazikou Road, Yongding gate, BeijingPostcode：100101
    Tel：010-87244116 87244117Fax :010-87287944
    RSS Email Alert

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return