Effect of <i>Rosa roxburghii </i>Tratt Powder on Alleviating Oxidative Stress Injury of Skeletal Muscle in Overtrained Rat

ZHANG Shuaijun; TANG Yuemei; ZHANG Dading; ZHANG Jin

doi:10.13386/j.issn1002-0306.2021090352

Volume 43 Issue 12

Jun. 2022

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Science and Technology of Food Industry > 2022 > 43(12): 338-346. > DOI: 10.13386/j.issn1002-0306.2021090352

ZHANG Shuaijun, TANG Yuemei, ZHANG Dading, et al. Effect of Rosa roxburghii Tratt Powder on Alleviating Oxidative Stress Injury of Skeletal Muscle in Overtrained Rat[J]. Science and Technology of Food Industry, 2022, 43(12): 338−346. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021090352.

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Effect of Rosa roxburghii Tratt Powder on Alleviating Oxidative Stress Injury of Skeletal Muscle in Overtrained Rat

1.
Science and Technology College Gannan Normal University, Ganzhou 341000, China
2.
The First People’s Hospital of Pingdingshan, Pingdingshan 467000, China

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Received Date: September 29, 2021
Available Online: April 07, 2022

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Objective: To explore the effects of different concentrations of Rosa roxburghii Tratt powder on antioxidant stress injury of skeletal muscle in overtrained rats. Methods: The rats were divided into the control group (C group), exercise group (HT group), low concentration Rosa roxburghii Tratt powder exercise group (L-HT group) and high concentration Rosa roxburghii Tratt powder exercise group (H-HT group). HT, L-HT and H-HT groups underwent treadmill training with increasing load for 6 weeks, respectively. During the training, L-HT group and H-HT group were intragastrically administered with 20 and 50 mg/mL Rosa roxburghii Tratt powder solution at the dose of 20 mL·kg⁻¹·d⁻¹, respectively. Group C and HT were given the same dose of saline. The samples collected 24 hours after last training were used to measure serum creatine kinase (CK), interleukin -1β (IL-1β) and tumor necrosis factor-α (TNF-α). The activities of superoxide dismutase (SOD) and the contents of malondialdehyde (MDA) and glutathione (GSH) in skeletal muscle were determined. The expressions of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1(HO-1), B cell lymphoma factor-2 (Bcl-2) and Bcl-2-related X protein(Bax) in skeletal muscle was detected. Results: Compared with the HT group, the activity of CK decreased (P<0.05), the activity of SOD increased (P<0.05), the contents of IL-1β, TNF-α and MDA decreased (P<0.05), the concentration of GSH increased (P<0.05), the expressions of Nrf2, HO-1 and Bcl-2 proteins increased (P<0.05), and the expression of Bax protein decreased in L-HT group (P<0.05). The activity of CK decreased (P<0.01), the activity of SOD increased (P<0.01), the contents of IL-1β, TNF-α and MDA decreased (P<0.01), the concentration of GSH increased (P<0.01), the expressions of Nrf2, HO-1 and Bcl-2 proteins increased (P<0.01), and the expression of Bax protein decreased in H-HT group (P<0.01). Compared with the L-HT group, the activity of CK decreased (P<0.05), the activity of SOD increased (P<0.05), the contents of IL-1β, TNF-α and MDA decreased (P<0.05), the expression of Nrf-2, HO-1 and Bcl-2 protein increased (P<0.05), and the expression of Bax protein decreased in H-HT group (P<0.05). Conclusion: Rosa roxburghii Tratt powder had a good protective effect on oxidative stress injury induced by overtraining in rats, and there was a dose-response relationship between the dosage of Rosa roxburghii Tratt powder and antioxidative stress injury in a certain range.
- Rosa roxburghii Tratt powder,
- overtraining,
- skeletal muscle,
- oxidative stress,
- damage

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