Research Progress in Chondroitinase

XIAO Mengyuan; WU Ruiyun; LI Pinglan

doi:10.13386/j.issn1002-0306.2021070372

Volume 43 Issue 15

Jul. 2022

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Science and Technology of Food Industry > 2022 > 43(15): 409-417. > DOI: 10.13386/j.issn1002-0306.2021070372

XIAO Mengyuan, WU Ruiyun, LI Pinglan. Research Progress in Chondroitinase[J]. Science and Technology of Food Industry, 2022, 43(15): 409−417. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021070372.

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Research Progress in Chondroitinase

Key Laboratory of Precision Nutrition and Food Quality, Key Laboratory of Functional Dairy, Ministry of Education, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China

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Received Date: August 01, 2021
Available Online: May 24, 2022

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Abstract

Abstract

Chondroitin sulfate (CS) is a negatively charged linear macromolecule polysaccharide interlaced with glucuronic acid and acetylgalactosamine. It has a variety of physiological activities, including repair of articular cartilage, antioxidant, lipid-lowering, anticoagulant, antithrombotic and antitumor, etc. However, the high molecular weight of CS restricts its effective use of many functions. Chondroitinase (Chase), as a type of lyase that degrades CS, can cleave CS to low-molecular-weight CS, which effectively overcomes the shortcomings of low bioavailability. Based on the author’s work, this article briefly introduces the biological activities of CS and low-molecular-weight CS, expounds on the catalytic mechanism of Chase cracking CS, systematically sorts out the types and sources of Chase, fermentation production and characterization, as well as research progress in recombinant expression and application, view intending to deeply understand the research status and development trend of low molecular weight CS and Chase, and promote the industrial production of Chase.
- low-molecular-weight chondroitin sulfate,
- chondroitinase,
- recombinant expression,
- application

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References

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