Research Progress of Ectopic Olfactory Trace Amine-associated Receptors

WANG Yanan; HUANG Kunlun; TONG Tao

doi:10.13386/j.issn1002-0306.2021050158

Volume 42 Issue 20

Oct. 2021

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Science and Technology of Food Industry > 2021 > 42(20): 14-22. > DOI: 10.13386/j.issn1002-0306.2021050158

WANG Yanan, HUANG Kunlun, TONG Tao. Research Progress of Ectopic Olfactory Trace Amine-associated Receptors[J]. Science and Technology of Food Industry, 2021, 42(20): 14−22. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021050158.

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Research Progress of Ectopic Olfactory Trace Amine-associated Receptors

WANG Yanan^1,,
HUANG Kunlun^{1, 2, 3, 4, ,},
TONG Tao^{1, 2, 4, ,}

1.
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
2.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing 100083, China
3.
Key Laboratory of Safety Assessment of Genetically Modifified Organism (Food Safety), Ministry of Agriculture, Beijing 100083, China
4.
Beijing Laboratory for Food Quality and Safety, Beijing 100083, China

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Received Date: May 19, 2021
Available Online: August 17, 2021

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Abstract

Abstract

Trace amine-associated receptors (TAARs) are a class of G-protein-coupled receptors, and with the exception of TAAR1, the remaining TAARs, like the olfactory receptors, are expressed in the olfactory epithelium and function to sense odorants. In recent years, the high expression of TAARs has been found in non-olfactory tissues, suggesting that TAARs may have important ectopic physiological functions. Recent studies have confirmed that endogenous and exogenous specific trace amines regulate a variety of physiological functions in non-olfactory tissues by acting on different TAARs, indicating that TAARs have the potential to become a new diagnostic and therapeutic target. This paper systematically introduces the expression of ectopic olfactory TAARs, endogenous and exogenous ligands, biogenic amines in food, ectopic olfactory TAARs-mediated signal pathways, and physiological and pathological functions. On the one hand, it provides new ideas for the future drug target development, physiological and pathological research, on the other hand, it also provides new research ideas for the biological activity of biogenic amines in food.

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