Effects of Ergosterol from Medicinal Fungi on Migraine Rats

LIU Yuguang; WANG Huan; WANG Shumin; LIU Zhixin; ZHANG Yue

doi:10.13386/j.issn1002-0306.2020090049

Volume 42 Issue 15

Jul. 2021

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Science and Technology of Food Industry > 2021 > 42(15): 327-331. > DOI: 10.13386/j.issn1002-0306.2020090049

LIU Yuguang, WANG Huan, WANG Shumin, et al. Effects of Ergosterol from Medicinal Fungi on Migraine Rats[J]. Science and Technology of Food Industry, 2021, 42(15): 327−331. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020090049.

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Effects of Ergosterol from Medicinal Fungi on Migraine Rats

LIU Yuguang^{1, 2,},
WANG Huan^1, ,,
WANG Shumin^1, ,,
LIU Zhixin²,
ZHANG Yue¹

1.
Changchun University of Chinese Medicine, Changchun 130117, China
2.
Jilin Asymchem Laboratories Co., Ltd., Dunhua 133700, China

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Received Date: September 09, 2020
Available Online: May 31, 2021

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Abstract

Abstract

Objective: To investigate anti-inflammatory and analgetic effect of the ergosterol from fungi on nitroglycerin (NTG)-induced migraine in rats. Methods: Oral administration of ergosterol (15 and 30 mg/kg), rats were injected with NTG to establish migraine animal model, after nitroglycerin induction, their typical symptoms were observed and the levels of NO, interleukin-6 (IL-6), interleukin-1β (IL-1β), 5-hydroxytryptamine (5-HT), norepinephrine (NE) and dopamine (DA) in serum and brain tissue were examined by ELISA. The alteration of NF-κBp65, JAK2 and STAT3 in brain were determined by Western blot (WB). Results: After injected with nitroglycerin, the rats scratched their heads frequently. Compared with the model group, the levels of NO, IL-6 and IL-1β were significantly reduced in serum by different doses of ergosterol, and 5-HT, NE and DA in brain tissue were increased. WB results showed that the expressions of P-NF-κBp65, P-JAK2 and P-STAT3 were significantly decreased by different doses of ergosterol (P < 0.001). Conclusion: Ergosterol has a significant anti-inflammatory and analgetic effect on migraine. The mechanisms may be connected with NF-κB and JAK/STAT signaling pathways.
- medicinal fungi,
- ergosterol,
- migraine,
- NF-κB

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References (26)

References

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