BAO Hairong, CHEN Baike. Preparation of Solid Dispersion and Its Application in Functional Food[J]. Science and Technology of Food Industry, 2021, 42(16): 397−403. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020080152.
Citation: BAO Hairong, CHEN Baike. Preparation of Solid Dispersion and Its Application in Functional Food[J]. Science and Technology of Food Industry, 2021, 42(16): 397−403. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020080152.

Preparation of Solid Dispersion and Its Application in Functional Food

More Information
  • Received Date: August 16, 2020
  • Available Online: May 28, 2021
  • Solid dispersion is considered to be one of the most successful ways to solve the poor water-solubility and dissolution rate of raw materials and drugs in the pharmaceutical field. Due to its unique advantages in solving the problems of water-solubility, poor stability and low bioavailability of functional active ingredients, solid dispersion has been gradually applied to the research and development of functional food. This paper reviews and summarizes the research status and development trend of solid dispersion from four aspects: classification, preparation technology, stability and its application in functional food. Combined with the background of the current post epidemic era, new requirements are put forward for the further application of solid dispersion in the food field in the future, and it is also hoped to provide new reference and research ideas for the further application of solid dispersion in the food field.
  • [1]
    Sekiguchi K, Obi N. Studies on absorption of eutectic mixture. i. a comparison of the behavior of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man[J]. Chem Pharm Bull,1961,9(11):866−872. doi: 10.1248/cpb.9.866
    [2]
    Sanjay Kshirsagar, Manisha Choudhari, Reshmi Sathyan, et al. Solubility enhancement by various techniques based on pharmaceutical and medicinal chemistry approach: An overview[J]. Asian Journal of Pharmacy and Technology,2019,9(2):141−146. doi: 10.5958/2231-5713.2019.00024.2
    [3]
    Scott V Jermain, Chris Brough, Robert O Williams. Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery-An update[J]. International Journal of Pharmaceutics,2018,535(1-2):379−392. doi: 10.1016/j.ijpharm.2017.10.051
    [4]
    刘建平, 生物药剂学与药物动力学[M]. 第4版. 北京: 人民卫生出版社, 2011: 125−130.
    [5]
    曹文. 药物制剂新技术在现代中药研究中的应用[J]. 临床合理用药志,2019,12(26):165−166.
    [6]
    李范珠, 李永吉. 中药药剂学[M]. 北京: 人民卫生出版社, 2012: 30−50.
    [7]
    Kawabata Y, Wada K, Nakatani M, et al. Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: Basic approaches and practical applications[J]. Int J Pharm,2011,420(1):1−10. doi: 10.1016/j.ijpharm.2011.08.032
    [8]
    Bertoni S, Albertini B, Passerini N. Spray congealing: An emerging technology to prepare solid dispersions with enhanced oral bioavailability of poorly water soluble drugs[J]. Molecules,2019,24(19):3471. doi: 10.3390/molecules24193471
    [9]
    李美云, 雷小小, 周江, 等. 星点设计-效应面法优化莲心总碱固体分散体渗透泵控释片处方[J]. 中草药,2016(47):3210.
    [10]
    Antónia Gonçalves, Nooshin Nikmaram, Shahin Roohinejad, et al. Production, properties, and applications of solid self-emulsifying delivery systems (s-seds) in the food and pharmaceutical industries[J]. Colloids & Surfaces A Physicochemical & Engineering Aspects,2018,538:108−126.
    [11]
    Schittny A, Philipp-bauer S, Detampel P, et al. Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid dispersions[J]. Journal of Controlled Release,2020,320:214−225. doi: 10.1016/j.jconrel.2020.01.031
    [12]
    马诗经. 姜黄素固体制剂制备及其抗炎作用与机理研究[D]. 广东: 广东工业大学, 2016.
    [13]
    李美琪. 大黄素和白屈菜红碱的固体化学研究[D]. 上海: 中国科学院大学(中国科学院上海药物研究所), 2019.
    [14]
    李安. L-硒-甲基硒代半胱氨酸固体分散体的制备及在牛奶中的应用[D]. 江西: 南昌大学, 2014.
    [15]
    Li M, Meng F, Tsutsumi Y, et al. Understanding molecular interactions in rafoxanide-povidone amorphous solid dispersions from ultrafast magic angle spinning nmr[J]. Molecular Pharmaceutics,2020,17(6):2196−2207. doi: 10.1021/acs.molpharmaceut.0c00317
    [16]
    Cunha R H, Nele M, Dias M L. Reaction and thermal behavior of vitrimer-like polyhydroxy esters based on polyethylene glycol diglycidyl ether[J]. Journal of Applied Polymer Science,2020,137(43):e49329. doi: 10.1002/app.49329
    [17]
    Lee, Ping I, Sun, et al. Probing the mechanisms of drug release from amorphous solid dispersions in medium-soluble and medium-insoluble carriers[J]. Journal of Controlled Release: Official Journal of the Controlled Release Society,2015,211:85−93. doi: 10.1016/j.jconrel.2015.06.004
    [18]
    Nieto K, Mallery S R, Schwendeman S P. Microencapsulation of amorphous solid dispersions of fenretinide enhances drug solubility and release from plga in vitro and in vivo[J]. International Journal of Pharmaceutics,2020:119475.
    [19]
    崔福德. 药剂学[M]. 第7版. 北京: 人民卫生出版社, 2012: 230−240.
    [20]
    吴玉小, 白长喜. 关于固体分散技术[J]. 内蒙古中医药,2013,32(7):132−134. doi: 10.3969/j.issn.1006-0979.2013.07.116
    [21]
    Bera S, Maity S, Ghosh B, et al. Development and characterization of solid dispersion system for enhancing the solubility and dissolution rate of dietary capsaicin[J]. Current Drug Therapy,2020,15(2):143−151. doi: 10.2174/1574885514666190724143351
    [22]
    N Zajc, A Obreza, M Bele. Physical properties and dissolution behaviour of nifedipine/mannitol solid dispersions prepared by hot melt method[J]. Int J Pharm,2005,291:51−58. doi: 10.1016/j.ijpharm.2004.07.042
    [23]
    Chen B, Wang X, Zhang Y, et al. Improved solubility, dissolution rate, and oral bioavailability of main biflavonoids fromSelaginella doederleinii extract by amorphous solid dispersion[J]. Drug Delivery,2020,27(1):309−322. doi: 10.1080/10717544.2020.1716876
    [24]
    Alhijjaj M, Yassin S, Reading M, et al. Characterization of heterogeneity and spatial distribution of phases in complex solid dispersions by thermal analysis by structural characterization and x-ray micro computed tomography[J]. Pharmaceutical Research,2017,34(5):971−989. doi: 10.1007/s11095-016-1923-3
    [25]
    Vo L N, Park C, Lee B J. Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs[J]. European Journal of Pharmaceutics & Biopharmaceutics Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E V,2013,85(3):799−813.
    [26]
    Chauhan H, Hui-Gu C, Atef E. Correlating the behavior of polymers in solution as precipitation inhibitor to its amorphous stabilization ability in solid dispersions[J]. Journal of Pharmaceutical Sciences,2013,102(6):1924−1935. doi: 10.1002/jps.23539
    [27]
    Bialleck S, Rein H. Preparation of starch-based pellets by hot-melt extrusion[J]. European Journal of Pharmaceutics & Biopharmaceutics Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E V,2011,79(2):440−448.
    [28]
    Roya Ghanavati, Azade Taheri, Alireza Homayouni. Anomalous dissolution behavior of celecoxib in pvp/isomalt solid dispersions prepared using spray drier[J]. Materials Science & Engineering C Materials for Biological Applications,2017,72:501.
    [29]
    游国叶, 樊轻亚, 杜晶, 等. Formulation optimization of capsaicin solid dispersion and its characterization[J]. 中国药房,2019,30(11):1464−1469.
    [30]
    徐德锋, 刘亚林, 王文杰, 等. 二甲基姜黄素固体分散体的制备及表征[J]. 中国医药工业杂志,2019,50(2):82−87.
    [31]
    Chen Yuejie, Wang Shujing, Wang Shan, et al. Sodium lauryl sulfate competitively interacts with hpmc-as and consequently reduces oral bioavailability of posaconazole/hpmc-as amorphous solid dispersion[J]. Molecular Pharmaceutics,2016,13(8):2787−2795. doi: 10.1021/acs.molpharmaceut.6b00391
    [32]
    Sinha S, Ali M, Baboota S, et al. Solid dispersion as an approach for bioavailability enhancement of poorly water-soluble drug ritonavir[J]. Aaps Pharmscitech,2010,11(2):518−527. doi: 10.1208/s12249-010-9404-1
    [33]
    Bisharat L, Alkhatib H S, Abdelhafez A, et al. Hot melt extruded zein for controlled delivery of diclofenac sodium: Effect of drug loading and medium composition[J]. International Journal of Pharmaceutics,2020:119503.
    [34]
    Marcos Bonilla-Hernández, Zapata-Catzin G A, Omar de Jesús Castillo-Cruz, et al. Synthesis and characterization of metformin-pluronic based polyurethanes for controlled drug delivery[J]. International Journal of Polymeric Materials,2020:1−12.
    [35]
    Nagi A S, Chatlapalli R S, Hasan S, et al. Compositions containing micronized tanaproget prepared by wet granulation: US20060247234 A1[P]. US 2014.
    [36]
    张锴, 王珂, 徐英楠, 等. 基于固体分散技术的山楂叶总黄酮缓释胶囊的研制及释药机制研究[J]. 中国现代应用药学,2017(3):78−84.
    [37]
    李庆国, 关世侠, 郭慧珍. 水飞蓟素缓释片的制备及体外释药机制研究[J]. 中国药房,2013,24(19):1770−1772. doi: 10.6039/j.issn.1001-0408.2013.19.15
    [38]
    Kolašinac N, Kachrimanis K, Homšek I, et al. Solubility enhancement of desloratadine by solid dispersion in poloxamers[J]. International Journal of Pharmaceutics,2012,436(1-2):161−170. doi: 10.1016/j.ijpharm.2012.06.060
    [39]
    Sahoo N G, Kakran M, Li L, et al. Dissolution enhancement of a poorly water-soluble antimalarial drug by means of a modified multi-fluid nozzle pilot spray drier[J]. Materials Science & engineering,2011,31(2):391−399.
    [40]
    Verhoeven E, Beer T R M D, Schacht E, et al. Influence of polyethylene glycol/polyethylene oxide on the release characteristics of sustained-release ethylcellulose mini-matrices produced by hot-melt extrusion: In vitro and in vivo evaluations[J]. European Journal of Pharmaceutics & Biopharmaceutics,2009,72(2):430−470.
    [41]
    Maniruzzaman M, Boateng J S, Bonnefille M, et al. Taste masking of paracetamol by hot-melt extrusion: anin vitro and in vivo evaluation[J]. European Journal of Pharmaceutics & Biopharmaceutics Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E V,2012,80(2):433−442.
    [42]
    Moes J, Koolen S, Huitema A, et al. Development of an oral solid dispersion formulation for use in low-dose metronomic chemotherapy of paclitaxel[J]. European Journal of Pharmaceutics & Biopharmaceutics,2013,83(1):87−94.
    [43]
    Haley McFall, Sandeep Sarabua, Vijaykumar Shankar, et al. Formulation of aripiprazole-loaded pH-modulated solid dispersions via hot-melt extrusion technology: In vitro and in vivo studies[J]. International Journal of Pharmaceutics,2019,554:302−311. doi: 10.1016/j.ijpharm.2018.11.005
    [44]
    王腾飞, 张先华, 王丽. 阿奇霉素固体分散体制备工艺研究[J]. 中国药业,2020,29(3):31−34. doi: 10.3969/j.issn.1006-4931.2020.03.009
    [45]
    Hwang I, Kang C Y, Park J B. Advances in hot-melt extrusion technology toward pharmaceutical objectives[J]. Journal of Pharmaceutical Investigation,2017,47(2):123−132. doi: 10.1007/s40005-017-0309-9
    [46]
    Repka M A, Bandari S, Kallakunta V R, et al. Melt extrusion with poorly soluble drugs-An integrated review[J]. International Journal of Pharmaceutics,2018,535(1-2):68−85.
    [47]
    Repka M A, Shah S, Lu J, et al. Melt extrusion: process to product[J]. Expert Opinion on Drug Delivery,2012,9(1):105−125. doi: 10.1517/17425247.2012.642365
    [48]
    Djuris J, Milovanovic S, Medarevic D, et al. Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid dispersions[J]. International Journal of Pharmaceutics,2018:65.
    [49]
    Ehsan Adeli. A comparative evaluation between utilizing sas supercritical fluid technique and solvent evaporation method in preparation of azithromycin solid dispersions for dissolution rate enhancement[J]. The Journal of Supercritical Fluids,2014:87.
    [50]
    Fromme A, Fischer C, Keine K, et al. Characterization and correlation of mobile phase dispersion of aqueous-organic solvent systems in centrifugal partition chromatography[J]. Journal of Chromatography A,2020:460990.
    [51]
    Tong H H Y, Du Z, Wang G N, et al. Spray freeze drying with polyvinylpyrrolidone and sodium caprate for improved dissolution and oral bioavailability of oleanolic acid, a bcs class IV compound[J]. International Journal of Pharmaceutics,2011,404(1−2):148−158. doi: 10.1016/j.ijpharm.2010.11.027
    [52]
    Lili Fitriani, Irma Afriyanti, Afriyani, et al. Solid dispersion of usnic acid-hpmc 2910 prepared by spray drying and freeze drying techniques[J]. Oriental Journal of Chemistry,2018,34(4):2083−2088. doi: 10.13005/ojc/3404048
    [53]
    Motallae S, Taheri A, Homayouni A. Preparation and characterization of solid dispersions of celecoxib obtained by spray-drying ethanolic suspensions containing pvp-k30 or isomalt[J]. Journal of Drug Delivery Science and Technology,2018,46:188−196. doi: 10.1016/j.jddst.2018.05.020
    [54]
    Shah N, Sandhu H, Phuapradit W, et al. Development of novel microprecipitated bulk powder (mbp) technology for manufacturing stable amorphous formulations of poorly soluble drugs[J]. International Journal of Pharmaceutics,2012,438(53-60).
    [55]
    Nishikawa R, Aridome N, Ojima N, et al. Structure and properties of fiber-reinforced polypropylene prepared by direct incorporation of aqueous solution of poly(vinyl alcohol)[J]. Polymer,2020,199:122566. doi: 10.1016/j.polymer.2020.122566
    [56]
    Dong Z, Chatterji A, Sandhu H, et al. Evaluation of solid state properties of solid dispersions prepared by hot-melt extrusion and solvent co-precipitation[J]. International Journal of Pharmaceutics,2008,355(1-2):141−149. doi: 10.1016/j.ijpharm.2007.12.017
    [57]
    牛晓磊, 贾润霞, 谈秀凤. 橙皮苷磷脂复合物固体分散体的制备、表征及其体内药动学研究[J]. 中成药,2020,42(9):2255−2259. doi: 10.3969/j.issn.1001-1528.2020.09.002
    [58]
    赵强, 武倩, 刘喜纲. 齐墩果酸固体分散体的制备[J]. 中成药,2018,40(10):2170−2176. doi: 10.3969/j.issn.1001-1528.2018.10.011
    [59]
    Shen X X, Branford-White C, White K, et al. Oral fast-dissolving drug delivery membranes prepared from electrospun polyvinylpyrrolidone ultrafine fibers[J]. Nanotechnology,2009,20(5):55104. doi: 10.1088/0957-4484/20/5/055104
    [60]
    Kawakami K. Miscibility analysis of particulate solid dispersions prepared by electrospray deposition[J]. International Journal of Pharmaceutics,2012,433(1-2):71−78. doi: 10.1016/j.ijpharm.2012.04.082
    [61]
    Yu D G, Yang J M, Branford-white C, et al. Third generation solid dispersions of ferulic acid in electrospun composite nanofibers[J]. International Journal of Pharmaceutics,2010,400(1-2):158−164. doi: 10.1016/j.ijpharm.2010.08.010
    [62]
    Balogh A, Farkas B, Palvolgyi A, et al. Novel alternating current electrospinning of hydroxypropylmethylcellulose acetate succinate (HPMCAS) nanofibers for dissolution enhancement: the importance of solution conductivity[J]. J Pharm Sci,2017,106(6):1634−1643. doi: 10.1016/j.xphs.2017.02.021
    [63]
    Nagy Z K, Balogh A, B Démuth, et al. High speed electrospinning for scaled-up production of amorphous solid dispersion of itraconazole[J]. Int J Pharm,2015,480(1−2):137−142. doi: 10.1016/j.ijpharm.2015.01.025
    [64]
    谭佳威, 孙如煜, 曾滟棱, 等. 固体分散技术在制剂领域的研究进展[J]. 药物评价研究,2017,40(8):1182−1188.
    [65]
    马艳秋, 曲韵智, 李津明. 固体分散体老化现象与抗老化的研究进展[J]. 中国新药杂志,2007,16(6):442−446. doi: 10.3321/j.issn:1003-3734.2007.06.006
    [66]
    王文月, 陈菊明, 庄珊珊, 等. 防止固体分散体老化的研究进展[J]. 中国医院药学杂志,2014,34(21):1858−1861.
    [67]
    Venecia W, Lou X C, Osterling D J, et al. Relationship between amorphous solid dispersion in vivo absorption andin vitro dissolution: Phase behavior during dissolution, speciation, and membrane mass transport[J]. Control Release,2018,292(3):172−182.
    [68]
    Large M J, Ogilvie S P, King A A K. Understanding solvent spreading for langmuir deposition of nanomaterial films: A hansen solubility parameter approach[J]. Langmuir,2017,33(51):14766−14771. doi: 10.1021/acs.langmuir.7b03867
    [69]
    Hormann T E, Jager N, Funke A, et al. Formulation per- formance and processability window for manufacturing a dual-polymer amorphous solid dispersion via hot-melt extrusion and strand pelletization[J]. Int J Pharm,2018,553(1-2):408−421. doi: 10.1016/j.ijpharm.2018.10.035
    [70]
    刘旭, 温新国, 缪旭, 等. 固体分散体物理稳定性影响因素及抗老化研究进展[J]. 中国现代应用药学,2011,28(8):710−717.
    [71]
    Yang J, Grey K, Doney J. An improved kinetics approach to describe the physical stability of amorphous solid dispersions[J]. Int J Pharm,2010,384(1-2):24−31. doi: 10.1016/j.ijpharm.2009.09.035
    [72]
    张佳佳, 朱源, 余江南, 等. 辛香料挥发油类化学成分的新型载体系统研究进展[J]. 中国中药杂志,2015,40(20):3932−3936.
    [73]
    时念秋, 张勇, 冯波, 等. 不同制备工艺制得姜黄素固体分散体的性质比较研究[J]. 中国药学杂志,2016,v. 51(10):49−54.
    [74]
    索炜. 大黄酸固体分散体在大鼠体内药物动力学和药效学的研究[D]. 河北: 河北联合大学, 2011.
    [75]
    姜修婷. 基于固体分散技术的叶黄素片的制备及评价[D]. 山东: 青岛科技大学, 2018.
    [76]
    陈钊, 蒋建中, 崔正刚. 表面活性剂-纳米颗粒相互作用与智能体系的构建(Ⅱ)相反电荷表面活性剂-纳米颗粒相互作用(i)——开关转移构建开关性Pickering乳状液和Pickering泡沫[J]. 日用化学工业,2019,49(8):492−502. doi: 10.3969/j.issn.1001-1803.2019.08.002
    [77]
    田诗伟, 毛国梁, 张珈瑜, 等. 开关型Pickering乳液体系[J]. 化学进展,2020,32(4):434−453.
    [78]
    王然, 张春玉, 刘洋, 等. 淀粉微粒和酪蛋白酸钠协同稳定Pickering乳状液性质研究[J]. 食品科学,,2020,41(12):60−65.
    [79]
    曹亚倩, 肖军霞, 蒋林宏, 等. 玉米纤维素在Pickering乳液制备中的应用研究[J]. 中国粮油学报,2020,35(4):54−60. doi: 10.3969/j.issn.1003-0174.2020.04.010
  • Cited by

    Periodical cited type(1)

    1. 马骋,付冉,宿书芳,刘艳明,高敏. 高效液相色谱法测定婴幼儿配方奶粉中维生素B_2含量的不确定度评定. 现代食品. 2024(09): 209-214 .

    Other cited types(0)

Catalog

    Article Metrics

    Article views (245) PDF downloads (41) Cited by(1)

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return