Recent Advances in Bioactivities and Technologies for Bioavailability Improvement of Capsicum Alkaloids

HU Fuxia; CHU Qiao; BAI Ruoxi; YANG Xingwen; ZHENG Zhenjia; WANG Zhaosheng

doi:10.13386/j.issn1002-0306.2020070406

Volume 42 Issue 15

Jul. 2021

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Science and Technology of Food Industry > 2021 > 42(15): 412-419. > DOI: 10.13386/j.issn1002-0306.2020070406

HU Fuxia, CHU Qiao, BAI Ruoxi, et al. Recent Advances in Bioactivities and Technologies for Bioavailability Improvement of Capsicum Alkaloids[J]. Science and Technology of Food Industry, 2021, 42(15): 412−419. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020070406.

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Recent Advances in Bioactivities and Technologies for Bioavailability Improvement of Capsicum Alkaloids

1.
College of Food Science and Engineering, Shandong Agricultural University, Key Laboratory of Food Processing Technology and Quality Control in Shandong Province, Taian 271018, China
2.
China National Institute of Standardization, Beijing 100191, China

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Received Date: July 30, 2020
Available Online: June 02, 2021

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Abstract

Abstract

Capsicum alkaloids, with various biological activities such as anti-cancer, anti-inflammatory, antibacterial, relieving pain, weight loss, anti-oxidation, protect the gastrointestinal tract, are the material basis and the main biologically active ingredients of capscium. However, the high stimulation, poor solubility, poor stability, liver first pass effect and other problems make its bioavailability low. In this review, recent advances in the mechanism of the versatile bioactivities of capsicum alkaloids and in the development of technologies for enhancing capsicum alkaloids bioavailability such as the use of liposome, microsphere, emulsion, hydroxypropyl -β- cyclodextrin, prodrug self-assembly technology are systematically summarized. It provides theoretical basis and technical support for the application of capsicum alkaloids in the future.
- capsicum alkaloids,
- biological activities,
- mechanism,
- bioavailability

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References (62)

References

[1]	曹悦, 马燕, 赵靓, 等. 辣椒籽及其高值化利用研究进展[J]. 食品工业科技,2018,39(21):320−327.
[2]	Srinivasan K. Biological activities of red pepper (Capsicum annuum) and its pungent principle capsaicin: A Review[J]. Critical Reviews in Food Science and Nutrition,2016,56(9):37−41.
[3]	Baby K C, Ranganathan T V. Effect of enzyme pretreatment on yield and quality of fresh green chilli (Capsicum annuum L) oleoresin and its major capsaicinoids[J]. Biocatalysis and Agricultural Biotechnology,2016,7:95−101. doi: 10.1016/j.bcab.2016.05.010
[4]	Akhtar F, Sharif H M, Mallick M A, et al. Capsaicin: Its biological activities and in silico target fishing[J]. Acta Poloniae Pharmaceutica,2017,74(2):321−329.
[5]	Mcclements D J, Xiao H. Designing food structure and composition to enhance nutraceutical bioactivity to support cancer inhibition[J]. Seminars in Cancer Biology,2017,46:215−226. doi: 10.1016/j.semcancer.2017.06.003
[6]	Chapa-oliver A M, Mejia-teniente L. Capsaicin: From plants to a cancer-suppressing agent[J]. Molecules,2016,21(8):931. doi: 10.3390/molecules21080931
[7]	Clark R, Lee S H. Anticancer properties of capsaicin against human cancer[J]. Anticancer Resarch,2016,36(3):837−843.
[8]	Islam A, Su A J, Zeng Z M, et al. Capsaicin targets tNOX (ENOX2) to inhibit G1 cyclin/CDK complex, as assessed by the cellular thermal shift assay (CETSA)[J]. Cells,2019,8:1275−1286. doi: 10.3390/cells8101275
[9]	Xu S C, Zhang L, Cheng X, et al. Capsaicin inhibits the metastasis of human papillary thyroid carcinoma BCPAP cells through the modulation of the TRPV1 channel[J]. Food Function,2018,9(1):344−354. doi: 10.1039/C7FO01295K
[10]	Chang H, Chen S, Chen S, et al. Capsaicin may induce breast cancer cell death through apoptosis-inducing factor involving mitochondrial dysfunction[J]. Human & Experimental Toxicology,2011,30(10):1657−1665.
[11]	Zhu M M, Yu X, Zheng Z M, et al. Capsaicin suppressed activity of prostate cancer stem cells by inhibition of Wnt/β-catenin pathway[J]. Phytotherapy Research,2019,18:1−8.
[12]	刘亚骁, 史本康. 辣椒素对膀胱癌细胞侵袭转移的影响[J]. 山东大学学报(医学版),2018,56(3):34−40.
[13]	肖潺潺, 陈茂剑, 梅凡彪, 等. 辣椒碱对肝癌SMMC-7721细胞增殖及HMGB1, IL-6表达的影响[J]. 中国实验方剂学杂志,2019,25(7):89−93.
[14]	Xie L, Xiang G D, Tang T, et al. Capsaicin and dihydrocapsaicin induce apotosis in human glioma cells via ROS and Ca²⁺ mediated mitochondrial pathway[J]. Molecular Medicine Reports,2016,14(5):4198−4208. doi: 10.3892/mmr.2016.5784
[15]	Wang F, Zhao J Y, Liu D, et al. Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition[J]. Cancer Biol Ther, 2016, 17: 1117−1125.
[16]	陈茂剑, 蒋玮, 覃庆洪, 等. 辣椒碱抗肿瘤作用分子机制的研究进展[J]. 中国实验方剂学杂志,2019,25(7):100−108.
[17]	陈田, 商婷婷, 何珍, 等. 辣椒生物碱的高速逆流色谱分离及抗炎活性测定[J]. 湖南农业大学学报(自然科学版),2018,44(1):56−61.
[18]	Sharath B S, Shivananda K, Vikas H M, et al. A systems biology approach to identify the key targets of curcumin and capsaicin that downregulate pro-inflflammatory pathways in human monocytes[J]. Computational Biology and Chemistry,2019,83:1−13.
[19]	Vasanthkumar T, Hanumanthappa M, Lakshminapayana R. Curcumin and capsaicin modulates LPS induced expression of COX-2, IL-6 and TGF-β in human peripheral blood mononuclear cells[J]. Cytotechnology,2019,71(5):963−976. doi: 10.1007/s10616-019-00338-x
[20]	Kim C S, Kawada T, Kim B S, et al. Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages[J]. Cellular Signalling,2003,15(3):299−306. doi: 10.1016/S0898-6568(02)00086-4
[21]	Oyedemi B O, Kotsia E M, Stapleton P D, et al. Capsaicin and gingerol analogues inhibit the growth of efflux-multidrug T resistant bacteria and R-plasmids conjugal transfer[J]. Ethnopharmacol,2019,245:111871. doi: 10.1016/j.jep.2019.111871
[22]	Silva H R A, De S G M, Fernandes J D, et al. Unravelling the effects of the food components ascorbic acid and capsaicin as a novel anti-biofilm agent against Escherichia coli[J]. Journal of Food Science and Technology,2020,57(3):1013−1020. doi: 10.1007/s13197-019-04134-5
[23]	Wang W H, Hao X P, Chen S G, et al. PH-responsive capsaicin @ chitosan nanocapsules for antibiofouling in marine applications[J]. Polymer,2018,158:223−230. doi: 10.1016/j.polymer.2018.10.067
[24]	张祖姣, 林建杏, 严欢. 辣椒素抑菌作用的初步研究[J]. 辣椒杂志,2012,10(4):37−39. doi: 10.3969/j.issn.1672-4542.2012.04.013
[25]	王梦, 赵佩霞, 张鹏, 等. 辣椒碱单体、二氢辣椒碱单体和降二氢辣椒碱单体抑菌效果研究[J]. 北京化工大学学报(自然科学版),2019,46(3):61−65.
[26]	张然, 李彪, 韦勇, 等. 天然辣椒素对几种植物病原菌的抑菌活性研究[J]. 湖北农业科学,2018,57(8):66−69.
[27]	Anand P, Bley K. Topical capsaicin for pain management: Therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8 patch[J]. British Journal of Anaesthesia,2011,107(4):490−502. doi: 10.1093/bja/aer260
[28]	Caterina M J, Schumacher M A, Toninaga M, et al. The capsaicin receptor: A heat-activated ion channel in the pain pathway[J]. Nature,1997,398:816−824.
[29]	Stevens R M, Ervin J, Nezzer J, et al. Randomized, double-blind, placebo-controlled trial of intraarticular trans-capsaicin for pain associated with osteoarthritis of the knee[J]. Arthritis & Rheumatology,2019,71(9):1524−1533.
[30]	Haanp M, Treede R D. Capsaicin for neuropathic pain: Linking traditional medicine and molecular biology[J]. European Neurology,2012,68(5):264−275. doi: 10.1159/000339944
[31]	Zou X J, Lin Q, Willis W D. Signal transduction: Effect of protein kinase C blockade on phosphorylation of NR1 in dorsal horn and spinothalamic tract cells caused by intradermal capsaicin injection in the rats[J]. Journal of Pain,2004,5:95−105. doi: 10.1016/j.jpain.2004.02.348
[32]	刘雄, 龚婷. 辣椒碱调节机体糖脂代谢的机理研究[J]. 食品科学技术学报,2018,36(1):18−24.
[33]	Westerterp-plantenga M S, Smeets A, Lejeune M P G. Sensory and gastrointestinal satiety effects of capsaicin on food intake[J]. International Journal of Obesity and Related Metabolic Disorders,2004,29(6):682−688.
[34]	焦丽华, 庞广昌. 辣椒素类物质的减肥作用机制[J]. 食品科学,2013,34(23):370−374.
[35]	Pande S, Srinivasan K. Potentiation of hypolipidemic and weight-reducing influence of dietary tender cluster bean (cyamopsis tetragonoloba) when combined with capsaicin in high-fat-fed rats[J]. Journal of Agricultural and Food Chemistry,2012,60(33):8155−8176. doi: 10.1021/jf301211c
[36]	范三红, 王娇娇, 李佳妮, 等. 辣椒红色素和辣椒碱体内抗氧化活性及降血脂功能研究[J]. 食品科学,2021,42(5):294−299.
[37]	段方娥, 何强. 辣椒素与槲皮素、芦丁协同抗氧化作用研究[J]. 食品科技,2019,44(10):294−299.
[38]	Materska M, Perucka I. Antioxidant activity of the main phenolic compounds isolated from hot pepper fruit (Capsicum annuum L.)[J]. Journal of Agricultural and Food Chemistry,2005,53:1750−1756. doi: 10.1021/jf035331k
[39]	Prakash U N, Srinivasan K. Beneficial influence of dietary spices on the ultrastructure and fluidity of the intestinal brush border in rats[J]. British Journal of Nutrition,2010,104(1):31−39. doi: 10.1017/S0007114510000334
[40]	Prakash U N, Srinivasan K. Fat digestion and absorption in spice-pretreated rats[J]. J Sci Food Agric,2012,92(3):503−510. doi: 10.1002/jsfa.4597
[41]	Chen D P, Xiong Y J, Lin Y, et al. Capsaicin alleviates abnormal intestinal motility through regulation of enteric motor neurons and MLCK activity: Relevance to intestinal motility disorders[J]. Molecular Nutrition & Food Research,2015,59(8):1482−1490.
[42]	Peng J, Li Y J. The vanilloid receptor TRPV1: Role in cardiovascular and gastrointestinal protection[J]. European Journal of Pharmacology,2010,627(1-3):1−7. doi: 10.1016/j.ejphar.2009.10.053
[43]	Bernard B, Tsubuku S, Kayahara T, et al. Studies of the toxicological potential of capsinoids: X. safety assessment and pharmacokinetics of capsinoids in healthy male volunteers after a single oral ingestion of CH-19 sweet extract[J]. International Journal of Toxicology,2008,27:137−147. doi: 10.1080/10915810802514476
[44]	Kodama T, Masuyama T, Kayahara T, et al. Studies of the toxicological potential of capsinoids XIV: A 26-week gavage toxicity study of dihydrocapsiate in rats[J]. International Journal of Toxicology,2010,29(2 Suppl):27−54.
[45]	Eloyi J O, Marina C D S, Petrilli R, et al. Liposomes as carriers of hydrophilic small molecule drugs: Strategies to enhance encapsulation and delivery[J]. Colloids & Surfaces B Biointerfaces,2014,123:345−363.
[46]	Zhu Y, Wang M M, Zhang J J, et al. Improved oral bioavailability of capsaicin via liposomal nanoformulation: Preparation, in vitro drug release and pharmacokinetics in rats[J]. Arch Pharm Res,2015,38:512−521. doi: 10.1007/s12272-014-0481-7
[47]	Ketzasmin T M, Evelin M B, Inocencio H C, et al. Mesoscopic modeling of the encapsulation of capsaicin by Lecithin/ Chitosan liposomal nanoparticles[J]. Nanomaterials,2018,8(6):425−437. doi: 10.3390/nano8060425
[48]	Andre, Shomorony, Claudia, et al. Prolonged duration local anesthesia by combined delivery of capsaicin-and tetrodotoxin-loaded liposomes[J]. Anesthesia & Analgesia,2019,129(3):709−717.
[49]	Humphrey A, Dalke A, Schulten K. VMD-visual molecular dynamics[J]. Mol. Gr. 1996, 14: 33-38.
[50]	Han J J, Zhang S H, Liu X B, et al. Fabrication of capsaicin emulsions: Improving the stability of the system and relieving the irritation to the gastrointestinal tract of rats[J]. Journal of the Science of Food and Agriculture,2020,100(1):129−138. doi: 10.1002/jsfa.10002
[51]	张娟. 辣椒碱微球的制备及其特性考察[D]. 石家庄: 河北医科大学, 2010.
[52]	Tan S R, Gao B, Tao Y, et al. Antiobese effects of capsaicin–chitosan microsphere (CCMS) in obese rats induced by high fat diet[J]. Journal of Agricultural and Food Chemistry,2014,62(8):1866−1874. doi: 10.1021/jf4040628
[53]	Zhang Y, Huang Z M, Omari-siaw E, et al. Preparation and in vitro-in vivo evaluation of sustained-release matrix pellets of capsaicin to enhance the oral bioavailability[J]. AAPS PharmSci Tech,2016,17(2):339−349. doi: 10.1208/s12249-015-0352-7
[54]	江霞云, 马凤森, 吴小娟. 辣椒碱乳胶剂的体外经皮渗透、镇痛作用及刺激性研究[J]. 中草药,2018,49(7):1569−1575. doi: 10.7501/j.issn.0253-2670.2018.07.013
[55]	Lu M W, Cao Y, Ho C T, et al. Organogel-derived capsaicin nanoemulsion has improved bioaccessibility and reduced gastric mucosa irritation[J]. Journal of Agricultural and Food Chemistry,2016,64:4735−4741. doi: 10.1021/acs.jafc.6b01095
[56]	Zheng H, Rui X, Xia G, et al. Complexation of capsaicin with hydroxypropyl-β-cyclodextrin and its analytical application[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy,2019,223:1−7.
[57]	Zi P, Yang X H, Kuang H F, et al. Effect of HP-β-CD on solubility and transdermal delivery of capsaicin through rat skin[J]. Int J Pharma,2008,358(1-2):151−158. doi: 10.1016/j.ijpharm.2008.03.001
[58]	Zhao Y Y, Sun C N, Shi F, et al. Preparation, characterization, and pharmacokinetics study of capsaicin via hydroxypropyl-beta-cyclodextrin encapsulation[J]. Pharmaceutical Biology,2015,54(1):1−9.
[59]	郑雯, 王远, 袁田青, 等. 响应面试验优化羟丙基-β-环糊精包合植物甾醇的水溶性改性工艺[J]. 食品科学,2017,38(20):161−168. doi: 10.7506/spkx1002-6630-201720023
[60]	李姝静, 霍冬昊, 袁丽, 等. 辣椒素与甲基-β-环糊精包合物制备工艺优化及性能研究[J]. 食品科技,2018,43(11):300−305.
[61]	Feng Y S, Zhu Y, Wan J Y, et al. Enhanced oral bioavailability, reduced irritation and increased hypolipidemic activity of self-assembled capsaicin prodrug nanoparticles[J]. Journal of Functional Foods,2018,44:137−145. doi: 10.1016/j.jff.2018.03.006
[62]	冯颖淑. 辛香料活性成分绿原酸和辣椒碱的纳米脂质给药系统研究[D]. 无锡: 江苏大学, 2016.

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