Research Progress in Biological Activity and Application of Lactoferrin

ZHANG Peng; ZHANG Haixia; TIAN Xiaojing; ZHANG Fumei; CAO Hong; CHEN Shien; MA Zhongren; DING Gongtao; SONG Li; Sharizah Alimat

doi:10.13386/j.issn1002-0306.2020070367

Volume 42 Issue 13

Jun. 2021

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Science and Technology of Food Industry > 2021 > 42(13): 404-411. > DOI: 10.13386/j.issn1002-0306.2020070367

ZHANG Peng, ZHANG Haixia, TIAN Xiaojing, et al. Research Progress in Biological Activity and Application of Lactoferrin[J]. Science and Technology of Food Industry, 2021, 42(13): 404−411. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2020070367.

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Research Progress in Biological Activity and Application of Lactoferrin

1.
College of Life Science and Engineering, Northwestern Minzu University, Lanzhou 730124, China
2.
China-Malaysia National Joint Laboratory, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China
3.
Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China
4.
Gannan Research Institute of Yak Milk, Hezuo 747000, China
5.
Biotechnology Division, The Center of Analysis for Drinking Water, Food and Environmental Safety, Department of Chemistry Malaysia (MOSTI), Petaling Jaya 999004, Malaysia

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Received Date: July 28, 2020
Available Online: April 22, 2021

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Abstract

Abstract

Lactoferrin is an iron-binding glycoprotein produced by mammalian epithelial cells and neutrophils and is one of the bioactive agents. It has a variety of biological activities, including antibacterial, antiviral, anticancer, anti-inflammatory, immune regulation and bone growth.It has been used for some of the treatment of oral diseases, infant formula milk powder nutrition enhancer, natural food preservative, natural cosmetics, also can be used as the prevention and treatment of many difficult diseases auxiliary and synthetic raw material or carrier, is widely used in food, medicine, cosmetics, animal husbandry and aquaculture, and other fields. This paper summarizes the biological activities of lactoferrin function and microbial mechanism of action, and the development and application of lactoferrin are introduced emphatically from the above five areas, to clarify further application prospect of lactoferrin.
- lactoferrin(LF),
- bioactivity,
- application

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References

[1]	占今舜, 张彬, 胡金杰. 乳铁蛋白的生物学功能及在仔猪生产上的应用[J]. 养猪,2011,5:21−23. doi: 10.3969/j.issn.1002-1957.2011.01.008
[2]	Baker E N, Baker H M. Molecular structure, binding properties and dynamics of lactoferrin[J]. Cellular & Molecular Life Sciences Cmls,2005,62(22):2531−2539.
[3]	杨巍, 马雪莹, 王晓宇. 乳铁蛋白的生物学活性[J]. 黑龙江科学,2011,2(4):43−44, 60.
[4]	孟维彬. 牛初乳的功能成分概述[J]. 山东畜牧兽医,2019,40(1):77−78. doi: 10.3969/j.issn.1007-1733.2019.01.048
[5]	Baker E N, Baker H M. A structural framework for understanding the multifunctional character of lactoferrin[J]. Biochimie,2009,91:3−10. doi: 10.1016/j.biochi.2008.05.006
[6]	Baker H M, Baker E N. Lactoferrin and iron: Structural and dynamic aspects of binding and release[J]. Biometals,2004,17:209−216. doi: 10.1023/B:BIOM.0000027694.40260.70
[7]	庞晓楠, 弘笑, 魏璇, 等. 乳铁蛋白的理化性质及其重组表达系统的研究进展[J]. 遗传,2015,37(9):873−884.
[8]	Cox T M, Mazurier J, Spik G, et al. Iron binding proteins and influx of iron across the duodenal brush border. Evidence for specific lactotransferrin receptors in the human intestine[J]. Biochimica et Biophysica Acta,1979,588(1):120−128. doi: 10.1016/0304-4165(79)90377-5
[9]	Hiroshi K, Makiko H, Shun’Ichi D. Effects of iron-saturated lactoferrin on iron absorption[J]. Agricultural and Biological Chemistry,1988,52(4):903−908.
[10]	Wayne B, Mitsunori T, Koji Y, et al. Identification of the bactericidal domain of lactoferrin[J]. Elsevier,1992,1121:130−136.
[11]	Shagaghi N, Palombo E A, Clayton A H A, et al. Archetypal tryptophan-rich antimicrobial peptides: Properties and applications[J]. World Journal of Microbiology & Biotechnology,2016,32:31.
[12]	Kraan M I A V D, Nazmi K, Teeken A, et al. Lactoferrampin, an antimicrobial peptide of bovine lactoferrin, exerts its candidacidal activity by a cluster of positively charged residues at the C-terminus in combination with a helix-facilitating N-terminal part[J]. Biological Chemistry,2005,386(2):137−142. doi: 10.1515/BC.2005.017
[13]	Cruz J, Ortiz C, Guzmán F, et al. Design and activity of novel lactoferrampin analogues against O157: H7 enterohemorrhagic Escherichia coli[J]. Biopolymers,2014,101:319−28. doi: 10.1002/bip.22360
[14]	Flores-Villaseñor H, Canizalez-Román A, Reyes-Lopez M, et al. Bactericidal effect of bovine lactoferrin, LFcin, LFampin and LFchimera on antibiotic-resistant Staphylococcus aureus and Escherichia coli[J]. Biometals,2010,23:569−78. doi: 10.1007/s10534-010-9306-4
[15]	Sijbrandij T, Ligtenberg A J, Nazmi K, et al. Effects of lactoferrin derived peptides on simulants of biological warfare agents[J]. World Journal of Microbiology & Biotechnology,2017,33(1):3.
[16]	Dix C, Wright O. Bioavailability of a novel form of microencapsulated bovine lactoferrin and its effect on inflammatory, markers and the gut microbiome: A pilot study[J]. Nutrients,2018,10(8):1115−1127. doi: 10.3390/nu10081115
[17]	Vega-Bautista A, Garza M D L, Julio César C, et al. The Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria[J]. International Journal of Molecular Ences,2019,20(19):4707−4731.
[18]	Biasibetti E, Rapacioli S, Bruni N, et al. In vitro lactoferrin-derived peptides antimicrobial activity: An experiment[J]. Nat Prod Res,2020.
[19]	Ekins A, Khan A G, Shouldice S R, et al. Lactoferrin receptors in gram-negative bacteria: Insights into the iron acquisition process[J]. Biometals,2004,17:235−243. doi: 10.1023/B:BIOM.0000027698.43322.60
[20]	Natalia P, Gucwa K, Olkiewicz K, et al. Antibiotic-based conjugates containing antimicrobial HLopt2 peptide: Design, synthesis, antimicrobial and cytotoxic activities[J]. ACS Chemical Biology,2019,14(10):2233−2242.
[21]	Strate B W A V D, Beljaars L, Molema G, et al. Antiviral activities of lactoferrin[J]. Antiviral Research,2001,52(3):225−239. doi: 10.1016/S0166-3542(01)00195-4
[22]	Ulvatne H, Samuelsen Ø, Haukland H H, et al. Lactoferricin B inhibits bacterial macromolecular synthesis in Escherichia coli and Bacillus subtilis[J]. FEMS Microbiology Letters,2004,237:377−384.
[23]	Karla A G-B, Ceballos-Olvera I, Sarahí L-C, et al. Bovine lactoferrin can decrease the in vitro biofilm production or shown synergy with antibiotics against Listeria and Escherichia coli isolates[J]. Protein and Peptide Letters,2020:27.
[24]	Sachdeva A, Nagpal J. META-A: Efficacy of bovine lactoferrin in Helicobacter pylori eradication[J]. Alimentary Pharmacology & Therapeutics,2009,29(7):720−730.
[25]	Morici P, Florio W, Rizzato C, et al. Synergistic activity of synthetic N-terminal peptide of human lactoferrin in combination with various antibiotics against carbapenem-resistant Klebsiella pneumoniae strains[J]. European Journal of Clinical Microbiology & Infectious Diseases,2017,36:1739−1748.
[26]	Sheffield C L, Crippen T L, Poole T L, et al. Destruction of single-species biofilms of Escherichia coli or Klebsiella pneumoniae subsp. pneumoniae by dextranase, lactoferrin, and lysozyme[J]. International Microbiology the Official Journal of the Spanish Society for Microbiology,2012,15:185−189.
[27]	Kádár B, Kocsis B, Kristof K, et al. Effect of antimicrobial peptides on colistin-susceptible and colistin-resistant strains of Klebsiella pneumoniae and Enterobacter asburiae[J]. Acta Microbiol Immunol Hung,2015,62:501−508. doi: 10.1556/030.62.2015.4.12
[28]	Almehdar H A, El-Baky N A, Alhaider A A, et al. Bacteriostatic and bactericidal activities of camel lactoferrins against Salmonella enterica serovar Typhi[J]. Probiotics Antimicrob Proteins,2020,12:18−31. doi: 10.1007/s12602-019-9520-5
[29]	Mosquito S, Ochoa T J, Cok J, et al. Effect of bovine lactoferrin in Salmonella ser. Typhimurium infection in mice[J]. Biometals,2010,23:515−21. doi: 10.1007/s10534-010-9325-1
[30]	Willer E D M, Lima R D L, Giugliano L G. In vitro adhesion and invasion inhibition of Shigella dysenteriae, Shigella flexneri and Shigella sonnei clinical strains by human milk proteins[J]. Bmc Microbiology,2004,4(1):18−18. doi: 10.1186/1471-2180-4-18
[31]	Redwan E M, Uversky V N, El-Fakharany E M, et al. Potential lactoferrin activity against pathogenic viruses[J]. Comptes Rendus-Biologies,2014,337(10):581−595. doi: 10.1016/j.crvi.2014.08.003
[32]	Oda H, Kolawole A O, Mirabelli C, et al. Antiviral effects of bovine lactoferrin on human norovirus[J]. Biochemistry and Cell Biology,2020:1−19.
[33]	Wakabayashi H, Oda H, Yamauchi K, et al. Lactoferrin for prevention of common viral infections[J]. Journal of Infection & Chemotherapy,2014,20:666−671.
[34]	Van S M, Perdijk O, Fick-Brinkhof H, et al. Bovine lactoferrin enhances TLR7-mediated responses in plasmacytoid dendritic cells in elderly women: Results from a nutritional intervention study with bovine lactoferrin, GOS and vitamin D[J]. Front Immunol,2018:9.
[35]	Seganti L, Di B A M, Marchetti M, et al. Antiviral activity of lactoferrin towards naked viruses[J]. Biometals,2004,17:295−299. doi: 10.1023/B:BIOM.0000027708.27142.bc
[36]	Mccann K B, Lee A, Wan J, et al. The effect of bovine lactoferrin and lactoferricin B on the ability of feline calicivirus (a norovirus surrogate) and poliovirus to infect cell cultures[J]. Journal of Applied Microbiology,2010,95(5):1026−1033.
[37]	Persson B D, Lenman A, Frängsmyr L, et al. Lactoferrin-hexon interactions mediate CAR-independent adenovirus infection of human respiratory cells[J]. Journal of Virology,2020,94(14).
[38]	Weng T-Y, Chen L-C, Shyu H-W, et al. Lactoferrin inhibits enterovirus 71 infection by binding to VP1 protein and host cells[J]. Antiviral Res,2005,67:31−37. doi: 10.1016/j.antiviral.2005.03.005
[39]	Pietrantoni A, Ammendolia M G, Tinari A, et al. Bovine lactoferrin peptidic fragments involved in inhibition of echovirus 6 in vitro infection.[J]Antiviral Res, 2006, 69: 98-106.
[40]	Zheng Y, Zhang W, Ye Q, et al. Inhibition of epsteinbarr virus infection by lactoferrin[J]. Journal of Innate Immunity,2012,4:387−398. doi: 10.1159/000336178
[41]	Cutone A, Rosa L, Ianiro G, et al. Lactoferrin's anti-cancer properties: Safety, selectivity, and wide range of action[J]. Biomolecules,2020,10(3):456. doi: 10.3390/biom10030456
[42]	Shankaranarayanan J S, Kanwar J R, Al-Juhaishi A J A, et al. Doxorubicin conjugated to immunomodulatory anticancer lactoferrin displays improved cytotoxicity overcoming prostate cancer chemo resistance and inhibits tumour development in TRAMP mice[J]. Scientific Reports,2016,6:32062. doi: 10.1038/srep32062
[43]	Antimo C, Barbara C, Andrea P, et al. Native and iron-saturated bovine lactoferrin differently hinder migration in a model of human glioblastoma by reverting epithelial-to-mesenchymal transition-like process and inhibiting interleukin-6/STAT3 axis[J]. Cellular Signalling,2020,65:109461. doi: 10.1016/j.cellsig.2019.109461
[44]	Gao C-H, Dong H-L, Tai L, et al. Lactoferrin-containing immuno complexes drive the conversion of human macrophages from M2- into M1-like phenotype[J]. Front Immunol,2018,9:37. doi: 10.3389/fimmu.2018.00037
[45]	Takayama Y, Aoki R. Roles of lactoferrin on skin wound healing[J]. Biochem Cell Biol,2012,90:497−503. doi: 10.1139/o11-054
[46]	Rosa L, Cutone A, Lepanto M S, et al. Lactoferrin: A natural glycoprotein involved in iron and inflammatory homeostasis[J]. International Journal of Molecular Sciences, 2017, 18(9): 1985.
[47]	Mancinelli R, Rosa L, Cutone A, et al. Viral hepatitis and iron dysregulation: Molecular pathways and the role of lactoferrin[J]. Molecules,2020,25(8).
[48]	Superti F, Agamennone M, Pietrantoni A, et al. Bovine lactoferrin prevents influenza a virus infection by interfering with the fusogenic function of viral hemagglutinin[J]. Viruses,2019,11(1):51. doi: 10.3390/v11010051
[49]	Zhao X, Ting S M, Sun G, et al. Beneficial role of neutrophils through function of lactoferrin after intracerebral hemorrhage[J]. Stroke,2018,49:1241−1247. doi: 10.1161/STROKEAHA.117.020544
[50]	Na Y J, Han S B, Kang J S, et al. Lactoferrin works as a new LPS-binding protein in inflammatory activation of macrophages[J]. Int. Immunopharmacol,2004,4:1187−1199. doi: 10.1016/j.intimp.2004.05.009
[51]	Olaf P, Van N R, Erik V D B, et al. Bovine lactoferrin modulates dendritic cell differentiation and function[J]. Nutrients,2018,10(7):848. doi: 10.3390/nu10070848
[52]	Shen-An H, Kerry J W, Sydney B, et al. Comparing efficacy of BCG/lactoferrin primary vaccination versus booster regimen[J]. Tuberculosis,2011,91(supp-S1):S90−S95.
[53]	Cornish J. Lactoferrin promotes bone growth[J]. Biometals,2004,17(3):331−335. doi: 10.1023/B:BIOM.0000027713.18694.91
[54]	Liu M, Fan F, Shi P, et al. Lactoferrin promotes MC3T3-E1 osteoblast cells proliferation via MAPK signaling pathways.[J]. Int J Biol Macromol,2018,107:137−143. doi: 10.1016/j.ijbiomac.2017.08.151
[55]	Fernandes K E, Weeks K, Carter D A. Lactoferrin is broadly active against yeasts and highly synergistic with amphotericin B[J]. Antimicrobial Agents and Chemotherapy,2020,64(5).
[56]	Huang F, Song Y, Chen W, et al. Effects of Candida albicans infection on defense effector secretion by human oral mucosal epithelial cells[J]. Arch Oral Biol,2019,103:55−61. doi: 10.1016/j.archoralbio.2019.05.013
[57]	Al-Sheikh H. Effect of lactoferrin and iron on the growth of human pathogenic Candida species[J]. Pak J Biol Sci,2009,12:91−94.
[58]	Lupetti A, Paulusma-Annema A, Welling M M, et al. Synergistic activity of the N-terminal peptide of human lactoferrin and fluconazole against Candida species[J]. Antimicrob Agents Chemother,2003,47:262−267. doi: 10.1128/AAC.47.1.262-267.2003
[59]	Anand N, Kanwar R K, Sehgal R, et al. Antiparasitic and immunomodulatory potential of oral nanocapsules encapsulated lactoferrin protein against plasmodium berghei[J]. Nanomedicine (Lond),2016,11:47−62. doi: 10.2217/nnm.15.181
[60]	Frontera L S, Moyano S, Quassollo G, et al. Lactoferrin and lactoferricin endocytosis halt Giardia cell growth and prevent infective cyst production.[J]. Sci Rep,2018:8.
[61]	Aguilar-Diaz H, Canizalez-Roman A, Nepomuceno-Mejia T, et al. Parasiticidal effect of synthetic bovine lactoferrin peptides on the enteric parasite Giardia intestinalis[J]. Biochem Cell Biol,2017,95:82−90. doi: 10.1139/bcb-2016-0079
[62]	Ochoa T J, Mendoza K, Carcamo C, et al. Is Mother's own milk lactoferrin intake associated with reduced neonatal sepsis, necrotizing enterocolitis, and death?[J]. Neonatology,2020,13:1−8.
[63]	卫生部, 食品营养强化剂使用标准: GB14880-2012[S]. 北京: 中国标准出版社, 2012: 1-335.
[64]	刘琨毅, 王琪, 吉莉莉, 等. 溶菌酶和乳铁蛋白在冷却牦牛肉涂膜保鲜中的应用[J]. 食品工业,2020,41(1):100−105.
[65]	付丽. 乳铁蛋白的抑菌作用及其对冷却肉保鲜和护色效果的研究[D]. 哈尔滨: 东北农业大学, 2006.
[66]	刘金昉. 南美白对虾保鲜、剥壳预处理影响因素的研究[D]. 保定: 河北农业大学, 2014.
[67]	Ishii N, Ryu M, Suzuki Y A. Lactoferrin inhibits melanogenesis by down-regulating MITF in melanoma cells and normal melanocytes[J]. Biochem Cell Biol,2017,95:119−125. doi: 10.1139/bcb-2016-0053
[68]	邢婷婷, 王全宇, 施雁勤, 等. 乳铁蛋白抗炎及美白功效的体外试验研究[J]. 香料香精化妆品,2020(1):24−28. doi: 10.3969/j.issn.1000-4475.2020.01.006
[69]	Rosa L, Lepanto M S, Cutone A, et al. Lactoferrin and oral pathologies: A therapeutic treatment[J]. Biochemistry and Cell Biology,2020(1):0052.
[70]	Morita Y, Ishikawa K, Nakano M, et al. Effects of lactoferrin and lactoperoxidase-containing food on the oral hygiene status of older individuals: A randomized, double blinded, placebo-controlled clinical trial[J]. Geriatr Gerontol Int,2017,17:714−721. doi: 10.1111/ggi.12776
[71]	Ochoa T J, Cleary T G. Effect of lactoferrin on enteric pathogens[J]. Biochimie,2009,91:30−34. doi: 10.1016/j.biochi.2008.04.006
[72]	Kaur G, Gathwala G. Efficacy of bovine lactoferrin supplementation in preventing late-onset sepsis in low birth weight neonates: A randomized placebo-controlled clinical trial[J]. J Trop Pediatr,2015,61:370−376. doi: 10.1093/tropej/fmv044
[73]	Alexander D B, Iigo M, Abdelgied M, et al. Bovine lactoferrin and Crohn's disease: A case study[J]. Biochem Cell Biol,2017,95:133−141. doi: 10.1139/bcb-2016-0107
[74]	Mohamed W A, Salama R M, Schaalan M F. A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway[J]. Biomed Pharmacother,2019,111:714−723. doi: 10.1016/j.biopha.2018.12.118
[75]	Hu P, Zhao D, Wang J, Zhao F, et al. The Effects of the combination of oral lactoferrin and iron injection on iron homestasis, antioxidative abilities and cytokines activities of suckling piglets[J]. Animals,2019,9(7):438. doi: 10.3390/ani9070438
[76]	Esmaeili A, Sotoudeh E, Morshedi V, et al. Effects of dietary supplementation of bovine lactoferrin on antioxidant status, immune response and disease resistance of yellowfin sea bream (Acanthopagrus latus) against Vibrio harveyi[J]. Fish Shellfish Immunol,2019,93:917−923. doi: 10.1016/j.fsi.2019.08.045
[77]	Habing G, Harris K, Schuenemann G M, et al. Lactoferrin reduces mortality in preweaned calves with diarrhea[J]. J Dairy Sci,2017,100:3940−3948. doi: 10.3168/jds.2016-11969
[78]	Mirabelli C, Wotring J W, Zhang C J, et al. Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing Candidates for COVID-19[J]. BioRxiv,2020.
[79]	Serrano G, Kochergina I, Albors A. et al. Liposomal lactoferrin as potential preventative and cure for COVID-19[J]. Int J Res Health Sci,2020,8(1):8−15.
[80]	韦柳萍, 吴青, 尹楠戈, 等. 乳铁蛋白预防早产儿晚发型败血症有效性和安全性的系统评价[J]. 中国临床药理学与治疗学,2018,23(6):653−660. doi: 10.12092/j.issn.1009-2501.2018.06.009

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