Abstract: In order to improve the embedding rate of Antarctic krill oil and reduce the costs, sodium caseinate, gelatin and maltodextrin were used as wall materials to prepared microencapsulation of Antarctic krill oil by spray drying method. Then, physicochemical properties of the products were studied. The results showed that the mass fraction of sodium caseinate was 24.55%, the mass fraction of gelatin was 4.86%, the mass ratio of core to wall was 0.33, the mass fraction of maltodextrin was 45.60%, and the embedding rate was 93.79%. The water content and ash content of the prepared microcapsule were 2.31%±0.12% and 2.04%±0.14%. The microcapsule power had no shrimp smell and the particle size focuses on 14.8~26.7 μm. The order of the effects of various factors on the embedding rate of Antarctic krill oil microencapsulated was: The mass ratio of core to wall > the mass fraction of gelatin > the mass fraction of sodium caseinate. The mechanical strength test showed that the release rate of Antarctic krill oil in the microcapsules was less than 0.3% under different pH conditions and centrifugal time, and the structure of the microcapsules was very stable.